Intraperitoneal Chemotherapy in a Pregnant Woman With Ovarian Cancer

Abstract

Pregnant women with ovarian cancer should be offered the opportunity to maximize their survival, including standard chemotherapeutic regimens used in nonpregnant patients.

Paclitaxel and Carboplatin Treatment for Advanced Ovarian Cancer during Pregnancy

“…Intraperitoneal chemotherapy has been suggested as an alternative administration route for pregnant women [8], although significant toxicity and poor treatment completion rates have prevented the widespread acceptance of this regimen [9]. On the other hand, an evaluation of the teratogenic potential of the support medication given with the chemotherapy should not be forgotten.…”

A review on pregnancy complicated by ovarian epithelial and non-epithelial malignant tumors: Diagnostic and therapeutic perspectives

“…Table 2 depicts the reported patients with EOC treated with chemotherapy during pregnancy, including details of maternal and neonatal outcome. Among 69 patients, the most frequent histologic subtypes were serous [1] , [4] , [8] , [30] , [40] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , mucinous [4] , [8] , [40] , [66] , [67] , [68] , [69] , [70] , [71] and endometrioid [40] , [72] , [73] , [74] in 35, 14 and 4 patients, respectively. These cases have documented the use of combination of taxane and platinum for stage III gestational EOC in both adjuvant and neoadjuvant setting.…”

“…Among the patients with EOC, 25 received the combination of platinum-taxane, 20 were treated with platinum based chemotherapy while platinum monotherapy was chosen in 13 ( Table 2 ). Spontaneous abortions were experienced in 4 cases [40] , IUGR in 2 [50] , [58] , whereas ventriculomegaly [65] , polyhydramnios [70] , PROM [71] , and respiratory distress syndrome [74] were documented in 4 cases , respectively. With regards to neonatal outcome, there were 2 reported deaths [1] , [65] , whereas Asperger syndrome [50] , and congenital talipes equinovarus [58] were diagnosed in 2 cases respectively.…”

Does Chemotherapy for Gynecological Malignancies during Pregnancy Cause Fetal Growth Restriction?

“…Although 6 cycles were originally planned, the treatment lasted for 4 cycles owing to preeclampsia, thrombocytopenia, and SGA fetal weight. These results should be interpreted with caution since it is unknown whether the growth restriction was a result of preeclampsia or the direct effect of intraperitoneal chemotherapy [19]. …”

“…The lack of precise uniform protocols of chemotherapy during pregnancy complicates the interpretation of the results. These different protocols involve different times of commencing chemotherapy, multiagent chemotherapy regimens for a single patient, use of chemotherapy alone or combined with surgery, choice of chemotherapeutics (which can be modified), dose of chemotherapy and intervals between cycles, method of administration, maternal wishes, and ethical issues [12–19]. Overlapping of chemotherapy with other factors may further complicate analysis.…”