Intraperitoneal administration of cisplatin via an in situ cross-linkable hyaluronic acid-based hydrogel for peritoneal dissemination of gastric cancer

Abstract

In situ cross-linkable HA hydrogels represent a promising biomaterial to prolong the retention and sustain the release of intraperitoneally administered CDDP in the peritoneal cavity and to enhance its antitumor effects against peritoneal dissemination.

The effect of extensive intraoperative peritoneal lavage therapy (EIPL) on stage III B + C and cytology-positive gastric cancer patients

“…In the current study, IPC was not applied to 30 patients in the late period because IPC often causes considerable side-effects despite having several worthy anticancer benefits [19,20]. Recently, some newly devised drug delivery systems using gelatin microspheres [15] or hyaluronic acid-based hydrogel [21] have been reported which demonstrated enhanced anticancer remedies with decreased adverse side-effects. EIPL therapy combined with some new applicable IPC system might yield a better outcome in the treatment of cancer patients.…”

A novel approach of optical biopsy using probe-based confocal laser endomicroscopy for peritoneal metastasis

“…We could watch and process pCLE images in real time, and after the fact, the images or movies were editable with Image cell version 3.8 (Mauna Kea Technologies, Paris, France). We established peritoneal metastases of gastric cancer in mice model by implanting gastric cancer cells, as previously described [29]. Mice were injected intra-abdominally (in the right flank) with 100 ll of 3.0 9 10 6 MKN-45 cells (JCRB0254) suspended in PBS (1:1 v/v).…”

α,β-Unsaturated aldehyde of hyaluronan—Synthesis, analysis and applications

“…One of the most versatile precursors is based on the preparation of HA-aldehyde and subsequent conjugation with biologically active N-nucleophiles (Mero, Pasqualin, Campisi, Renier, & Pasut, 2013) or with polyamine to form hydrogels (Li, Fu & Zhang, 2014). The main advantage of the aldehydic groups is their ability to react with a wide range of the amino compounds even under the physiological conditions (Emoto et al, 2014). Direct oxidation of a macromolecular chain of HA is based either on cleavage of a vicinal diol with sodium periodate in the positions 2 and 3 of GlcNAc (Kuo, 2005;Wang, Oommen, Yan, & Warghese, 2013), or on the oxidation of the position 6 of GlcNAc with TEMPO/NaClO Sedova et al, 2013) eventually with Dess-Martin periodate (Buffa, Kettou, Pospíšilová, Berková & Velebný, 2011;Šedova et al, 2013).…”