Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis)

D’Hooghe, Thomas; Bambra, Charanjit S.; Raeymaekers, Barbara M.; Jonge, Inge De; Lauweryns, Jo M.; Koninckx, Philippe

doi:10.1016/0002-9378(95)90180-9

Cited by 165 publications

(133 citation statements)

References 21 publications

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“…Since rodents do not have menses or develop spontaneous endometriosis, the ectopic autologous transplantation of uterine tissue in this model (52) may not sufficiently replicate human endometriosis. With this in mind, the baboon endometriosis model was established by intrapelvic seeding of menstrual eutopic endometrium on top of the pelvic organs (20).…”

Section: Discussionmentioning

confidence: 99%

“…During laparoscopy, the resulting paste (1000 ± 250 mg) was autologously seeded onto various peritoneal sites (uterosacral ligaments, uterovesical fold, pouch of Douglas, ovaries and ovarian fossae), as described previously (20). A second videolaparoscopy was performed 52.3 ± 12.3 days (mean ± SD; range, 34-68 days) later to document the number, surface area and volume of the endometriotic lesions, to determine the presence, localization and extent of adhesions, and to calculate the adapted rAFS score and assigned stage of disease according to the revised classification system of the American Society for Reproductive Medicine (21).…”

Section: Induction Of Endometriosismentioning

confidence: 99%

“…Surgically transplanted endometrial tissue in the baboon provides a primate model to study the effects of experimental drugs on ectopic endometrial tissue (10,11,20). Baboon endometriotic implants show histologic transformations similar to those seen in human endometriotic lesions.…”

Section: Introductionmentioning

confidence: 99%

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PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

Lebovic

Mwenda

Chai

et al. 2007

Fertility and Sterility

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Objective-To determine the effects of a thiazolidinedione (TZD) agonist of peroxisome proliferator-activated receptor (PPAR)-γ, rosiglitazone, in a baboon model of established endometriosis.Design-Prospective, randomized, placebo-controlled study.Setting-Experimental surgery laboratory at the Institute of Primate Research in Nairobi, Kenya.Animal(s)-Endometriosis was induced using intrapelvic injection of eutopic menstrual endometrium in 12 female baboons with a normal pelvis that had undergone at least one menstrual cycle since the time of captivity.Intervention(s)-Induction of endometriosis by laparoscopy was performed in 12 baboons with a normal pelvis. Endometrial tissue was extracted from each baboon by curettage and a standard amount of endometrium was then seeded onto several peritoneal sites as previously described. About 34-68 days after the induction of laparoscopy, a pre-treatment laparoscopy (baseline disease assessment) was performed in the baboons to record the extent of endometriotic lesions. The 12 baboons were randomized into 3 groups and treated from the day after the staging laparoscopy for a total duration of 30 days. They received either PBS tablets (n=4, placebo control; placebo tablets once a day by mouth for 30 days), GnRH-antagonists (n=4, active control; Ganirelix acetate 125 μg/day for 30 days) or rosiglitazone (n=4, test drug, 2 mg by mouth each day for 30 days). A 3 rd and final laparoscopy on day 30 after the start of treatment was performed to record the extent of endometriosis. The type of lesion (typical, red, white and suspicious) was recorded. Biopsies were obtained to confirm the histological presence of endometriosis.Main Outcome Measure(s)-A videolaparoscopy was performed 30 days after treatment to document the number and surface area of endometriotic lesions as well as to calculate the revised American Society for Reproductive Medicine score (rAFS) and stage.Corresponding author Dan I. Lebovic, M.D., M.A., Department of Obstetrics and Gynecology, University of Michigan, Tel: 734-615-8257, Fax: 734-647-1006, E-mail: lebovic@umich.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Discussionmentioning

confidence: 99%

Section: Induction Of Endometriosismentioning

confidence: 99%

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PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

Lebovic

Mwenda

Chai

et al. 2007

Fertility and Sterility

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“…It has been shown by the group of D'Hooghe that the intrapelvic injection of menstrual endometrium causes pelvic endometriosis in the baboon model. 16 Moreover, it has been demonstrated recently that eutopic endometrium shares alterations with the ectopic tissue that are not found in the eutopic endometrium of disease-free women concerning apoptosis, cell proliferation and aromatase-over expression. 17 -20 Therefore, the view has been advanced that the primary defect in endometriosis may be located in the eutopic endometrium of these women.…”

Section: Discussionmentioning

confidence: 99%

Diminished pregnancy rates in endometriosis due to impaired uterotubal transport assessed by hysterosalpingoscintigraphy

Kissler

Hamscho

Zangos

et al. 2005

BJOG

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“…Several experiments have demonstrated that endometrium-derived cells are capable of establishing endometriotic implants (Te Linde and Scott 1950;Ridley and Edwards 1958;D'Hooghe, Bambra et al 1995). Xenografts of human endometrial tissue or dissociated endometrial cells have been used in immunocompromised mouse to investigate pathogenesis of endometriosis (Grümmer 2006;Masuda, Maruyama et al 2007).…”

Section: Stem Cell-based Theory Of Endometriosismentioning

confidence: 99%

Endometrial Stem Cells and Endometriosis

Ai¹,

Sadroddiny²

2012

Endometriosis - Basic Concepts and Current Research Trends

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Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis)

Cited by 165 publications

References 21 publications

PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled study

Diminished pregnancy rates in endometriosis due to impaired uterotubal transport assessed by hysterosalpingoscintigraphy

Endometrial Stem Cells and Endometriosis

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