Intrapartum fever at term: Serum and histologic markers of inflammation

Smulian, John C.; Bhandari, Vineet; Vintzileos, Anthony M.; Shen‐Schwarz, Susan; Quashie, Carlene; Lai-Lin, Yu-Ling; Ananth, Cande V.

doi:10.1067/mob.2003.11

Cited by 81 publications

(69 citation statements)

References 20 publications

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“…Pathologic studies of the placenta have traditionally focused on histologic chorioamnionitis [9][10][11][12], which is mainly a maternal inflammatory response [11][12][13]. Several decades ago, examination of the umbilical cord for the detection of funisitis was proposed as a method to assess the likelihood of congenital infection because inflammation of the umbilical cord is a fetal inflammatory response [14,15].…”

Section: The Frequency Of Funisitis In Term Deliveriesmentioning

confidence: 99%

Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation

Lee

Romero

Kim

et al. 2006

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective. Funisitis is the histologic counterpart of the fetal inflammatory response syndrome, which is a multisystemic disorder associated with impending preterm delivery and adverse neonatal outcome. The purpose of this study was to examine the relationship between funisitis and the microbiologic status of amniotic fluid (AF) and AF white blood cell (WBC) count in patients at term. Methods. The relationship between the presence of funisitis, AF culture, and AF WBC count was examined in 832 consecutive patients who delivered a term neonate within 72 hours of amniocentesis. AF was cultured for aerobic and anaerobic bacteria, as well as for mycoplasmas. Funisitis was diagnosed in the presence of neutrophil infiltration into the umbilical vessel walls or Wharton's jelly. AF WBC count was analyzed in a hemocytometer chamber. Nonparametric statistics were used for data analysis. Results. Funisitis was present in 4% (30/832) of cases. A positive AF culture was more common in cases with funisitis than in those without funisitis (17% vs. 5%; p 5 0.05). Patients with funisitis had a significantly higher median AF WBC count than those without funisitis (median 41000 cells/mm 3 vs. median 2 cells/mm 3 ; p 5 0.001). The frequency of funisitis and of a positive AF culture was 1% in women without labor and with intact membranes and the frequencies and the median AF WBC count increased in the presence of labor or rupture of membranes. Conclusion. Funisitis is present in 4% of women at term and is associated with microbial invasion of the amniotic cavity (MIAC) and inflammation as reflected by increased AF WBC count.

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Section: The Frequency Of Funisitis In Term Deliveriesmentioning

confidence: 99%

Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation

Lee

Romero

Kim

et al. 2006

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Korioamnionitis merupakan faktor risiko infeksi awitan dini pada neonatus, dengan angka kejadian 1%-10%. 30,31 Faktor risiko lain seperti KPD, perubahan warna dan bau pada cairan ketuban, serta bayi prematur tidak dapat dijadikan prediktor infeksi pada penelitian kami, sama dengan hasil yang dicapai Shah dkk. 32 Keadaan ini dapat dijelaskan dengan adanya hubungan bermakna antara jumlah tindakan bedah Caesar untuk mengakhiri kehamilan dengan indikasi KPD dan gawat janin.…”

Section: Metodeunclassified

Leukositosis pada Ibu Sebagai Salah Satu Faktor Risiko Infeksi Neonatal Awitan Dini: Telaah Klinis di RSAB Harapan Kita

Hendrarto¹

2016

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Latar belakang. Infeksi awitan dini neonatal masih menjadi masalah karena tingginya angka kesakitan,kematian, biaya perawatan, dan akan menimbulkan komplikasi tumbuh kembang di kemudian harikhususnya bayi prematur. Di sisi lain diagnosis cepat sangat diperlukan terutama untuk menentukan saatpemberian antibiotik.Tujuan. Mengetahui hubungan faktor risiko maternal sebagai prediktor terjadinya infeksi neonatal awitandini (INAD).Metode. Studi kasus kontrol, retrospektif terhadap pasien neonatus yang dirawat di Unit Perawatan IntensifNeonatal, Rumah Sakit Anak dan Bunda ”Harapan Kita” sejak Desember 2008 sampai dengan November2010. Data dianalisis secara multivariat regresi logistik dengan menggunakan program SPSS 16.0.Hasil. Subyek penelitian 566 bayi baru lahir dari 5094 kelahiran selama periode dua tahun; ditemukan179 neonatus (35,17 per 1000 kelahiran) didiagnosis tersangka INAD, 12 (6,7%) terbukti berdasarkanpemeriksaan biakan darah. Jenis kuman adalah Staphylococcus epidermidis (6), candida sp (2), Staphylococcusaureus (1), Streptococcus B hemoliticus (1), Streptococcus maltophilia (1), serratia sp (1). Faktor risikoleukositosis (􀂕15.000 sel/mm3) pada ibu dan adanya leukosit (􀂕5/LPB) dalam cairan lambung bayi yangdiaspirasi segera setelah lahir memiliki probabilitas sebagai prediktor kemungkinan neonatus menderitainfeksi awitan dini sebesar 67.7%.Kesimpulan. Peningkatan jumlah leukosit darah ibu dan peningkatan jumlah leukosit dalam cairan lambungbayi yang diaspirasi segera setelah lahir merupakan prediktor kemungkinan neonatus menderita infeksiawitan dini

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“…La administración de anestesia epidural se describe como la segunda causa más frecuente de fiebre intraparto [1][2][3][4][5]7,8 . En nuestro caso, todas las mujeres requirieron anestesia epidural durante el trabajo de parto, por lo que es difícil diferenciar entre fiebre secundaria a anestesia epidural o fiebre de origen infeccioso.…”

Section: Comentariosunclassified

“…La causa más frecuente de fiebre intraparto es el uso de la anestesia epidural que es una fiebre no infecciosa [1][2][3][4][5][6][7][8][9] . Existen también otros factores de riesgo clásicos, como la primiparidad, trabajo de parto prolongado, rotura de membranas prolongada, colonización por estreptococo del grupo B. .…”

Section: Introductionunclassified

La fiebre intraparto como factor predictivo de parto distócico y resultado neonatal adverso

Sigler

Miguelez

Urdangaray

et al. 2015

Clínica e Investigación en Ginecología y Obstetricia

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Intrapartum fever at term: Serum and histologic markers of inflammation

Cited by 81 publications

References 20 publications

Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation

Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation

Leukositosis pada Ibu Sebagai Salah Satu Faktor Risiko Infeksi Neonatal Awitan Dini: Telaah Klinis di RSAB Harapan Kita

La fiebre intraparto como factor predictivo de parto distócico y resultado neonatal adverso

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