Intraparenchymatous adenomatoid tumor dependent on the rete testis: A case report and review of literature

Pacheco, Antonio Jiménez; Torres, JL Martínez; Guardia, F Valle Diaz de la; Polo, M. Arrabal; Gómez, Armando Zuluaga

doi:10.4103/0970-1591.45551

Cited by 23 publications

(22 citation statements)

References 5 publications

(5 reference statements)

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“…3,[11][12][13] Electron Microscopy Features Ultrastructural examination reveals epithelial cells joined by intercellular junctions, including desmosomes and junctional complexes, with lumen formation. Numerous cytoplasmic filaments are observed, including tonofibrils; cytoplasmic glycogen is also present.…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…In addition, the cytologic atypia seen in malignant mesothelioma greatly exceeds that seen in adenomatoid tumor. 12,14 Rete testis adenocarcinoma is also an important differential diagnosis, particularly when the tumors are infiltrative into the adjacent testicular hilus and lack the classic presentation of thickened tunica vaginalis, which is commonly seen in mesothelioma of the tunica vaginalis testis. Both tumors can have papillary and tubular patterns microscopically; however, rete testis carcinoma is predominantly located within the rete testis, particularly within the hilus, and the tumor is continuous with the rete testis epithelium.…”

Section: Differential Diagnosismentioning

confidence: 99%

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Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Chekol

Sun²

2012

Archives of Pathology &Amp; Laboratory Medicine

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Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor representing 0.3% to 5% of all malignant mesotheliomas. Gross examination of testicular mesotheliomas typically reveals tumor nodules studding the thickened tunica vaginalis and, in some cases, infiltrating the testicular parenchyma, leading to diagnostic challenges. Microscopically, the tumor is characterized by epithelioid cells arising from the tunica vaginalis with papillary, tubulopapillary, or solid architectural patterns. The papillae are usually lined by a single layer of cells with relatively bland cytologic features. An epithelial cell phenotype admixed with a sarcomatoid pattern has also been described in a few cases. Immunohistochemically, the tumor is usually positive for calretinin, Wilms tumor-1, epithelial membrane antigen, D2-40, thrombomodulin, cytokeratin 7, and cytokeratin 5/6. Electron microscopic studies reveal epithelial cells joined by tight junctions, forming lumina, and displaying long microvilli with length to width ratios often greater than 10. The most important differential diagnostic considerations include florid mesothelial hyperplasia, adenomatoid tumor, carcinoma of the rete testis, and serous papillary tumors. In addition, the various types of testicular germ cell tumors should be considered, including seminomas, embryonal carcinomas, and intratubular germ cell tumors, particularly in tumors with testicular parenchymal involvement. Pleomorphic sarcomas should also be considered, particularly when dealing with the biphasic variant. The prognosis for this entity is grave, with a median survival of 23 months. Aggressive therapy with radical orchiectomy remains the mainstay of treatment.

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Section: Immunohistochemistrymentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Chekol

Sun²

2012

Archives of Pathology &Amp; Laboratory Medicine

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“…It is known that these tumors develop from appendix testis, appendix epididymis and other Müllerian residues. Müllerian markers CK7, PAX 8 and CA125 can be positive in these tumors (9) . One of our cases was high-grade serous carcinoma and was positively stained with Müllerian markers.…”

Section: Discussionmentioning

confidence: 93%

Histopathological Features of Paratesticular Solid Tumors: 5 Years Experience

Çoban¹,

Yıldız²,

Kıran³

et al. 2020

İKSST

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Objective: The aim of this study is to determine the types of tumors seen in the paratesticular region, to discuss the most prominent histopathological features and differential diagnoses of rare tumors among our cases as well as to compare the findings with the literatüre. Method: The patients operated in Bezmialem Vakıf University for inguinal hernia and paratesticular tumor between 2014-2019 and diagnosed as paratesticular tumor were added to our study. Diagnosis, clinical findings and demographic data of the cases were recorded. Results: We had a series of 21 paratesticular tumors with a mean age of 58.8 years. The most common; benign tumor was lipoma and malignant tumor was liposarcoma. Hemangioma, ovarian type serous carcinoma and mesothelioma were also rarely seen in the literature. Conclusion: Paratesticular tumors are composed of tumors originating from rete testis, epididymis and tunica vaginalis, soft tissue tumors and metastatic tumors. The most common epithelial tumors are adenomatoid tumors. The most common benign and malignant mesenchymal tumors are lipoma and liposarcoma, respectively. Histomorphological appearance may be difficult especially in malignant epithelial tumors. Although immunohistochemical markers are helpful in differentiation, the transition between the lesion and non-neoplastic epithelium is important. Paratesticular tumors are quite rare. For this reason, at this location both primary tumors-especially malignant-and metastasis can be challenging. They should be kept in mind for differential diagnosis.

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“…In many cases, the similar imaging studies and clinical signs make it hard to distinguish adenomatoid tumors from malignant intratesticular tumors, leading to unnecessary extensive surgical excision of the whole testis ( 11 ). The present study is the first reported case to avoid extensive surgical excision based on intra-operative evaluation when this dilemma was encountered.…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumors of the testis: A report of two cases and review of the literature

Chen

et al. 2014

Oncology Letters

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Adenomatoid tumors are rare benign neoplasms that normally occur in the scrotum. The clinical symptoms and routine examinations mean that it is difficult to distinguish adenomatoid tumors from malignant intratesticular solid tumors, which may result in unnecessary orchidectomies. The present report describes two adenomatoid tumor patients treated between 2006 and 2013 at the Peking University Shenzhen Hospital who presented with an asymptomatic mass in the scrotum. Based on thorough analysis of clinical features, blood, radiological images and intra-operative findings, limited local excisions were performed, revealing adenomatoid tumors of the testis on pathological examination. The patients were followed up and exhibit no recurrence at the time of writing. The present report also summarizes the morphological and immunohistochemical features of paratesticular tumors and reviews the literature to improve understanding of these rare lesions and assist in accurate diagnosis.

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Intraparenchymatous adenomatoid tumor dependent on the rete testis: A case report and review of literature

Cited by 23 publications

References 5 publications

Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Histopathological Features of Paratesticular Solid Tumors: 5 Years Experience

Adenomatoid tumors of the testis: A report of two cases and review of the literature

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