Intrapancreatic, Liver, and Skeletal Muscle Fat Depositions in First Attack of Acute Pancreatitis Versus Health

Ko, Jung Hwa; Al-Ani, Zena; Long, Kieran; Tarrant, Conor; Skudder-Hill, Loren; Petrov, Maxim S.

doi:10.14309/ajg.0000000000001951

Cited by 14 publications

(9 citation statements)

References 48 publications

(67 reference statements)

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“…Subgroup analyses stratified by the diagnosis of diabetes and obesity did not reveal significant interactions. Recent studies have observed an association between intrapancreatic fat disposition and the development of acute pancreatitis, even after adjusting for multiple variables including fasting plasma glucose and BMI ( 43 , 44 ). BMI has been considered a poor proxy for intrapancreatic fat deposition ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

et al. 2023

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INTRODUCTION: Hypertriglyceridemia is the third most common etiology of acute pancreatitis. Whether triglyceride variability, independent of absolute triglyceride levels, is a predictor of acute pancreatitis is unknown. METHODS:We identified 98,819 patients who were diagnosed with hyperlipidemia between January 1, 2007, and December 31, 2013, and had at least 1 triglyceride measurement annually for 4 consecutive years from the Chang Gung Research Database in Taiwan. Triglyceride variability, defined as variability independent of the mean, was calculated in the 4-year run-in period. The patients were stratified according to the quartiles of triglyceride variability and were followed until December 31, 2019, for first attack of acute pancreatitis. RESULTS:During a mean follow-up of 5.9 years, 825 (0.83%) patients were newly diagnosed with acute pancreatitis (14.1 events per 10,000 person-years; 95% confidence interval 13.2-15.1). Triglyceride variability was significantly associated with an increased risk of acute pancreatitis, independent of baseline triglyceride and mean triglyceride levels (hazard ratio, 1.28 [95% confidence interval 1.05-1.57] for the highest vs the lowest quartiles of triglyceride variability; P for trend 5 0.006 over the quartiles of triglyceride variability). Subgroup analysis showed that this association was more pronounced among the patients with a higher neutrophil-to-lymphocyte ratio (P for trend 5 0.022).

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Section: Discussionmentioning

confidence: 99%

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

et al. 2023

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“…4,5 Limitations of this study include its cross-sectional design, as no causal inference can be made from it. [39][40][41][42] Longitudinal studies are now warranted to investigate temporal changes in bile acids and ectopic fat deposition in order to establish causality. 43,44 As the study was the first to investigate total bile acids in the context of IPFD and SMFD, 5 we were unable to estimate the required sample size prior to the commencement of the study.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Bile Acids with Fat Deposition in the Pancreas, Liver, and Skeletal Muscle

Al-Ani¹,

Ko²,

Petrov³

2023

CEG

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Ectopic fat deposition is well appreciated as a key contributor to digestive and liver diseases. Bile acids have emerged as pleiotropic signalling molecules involved in numerous metabolic pathways. The aim was to study the associations of bile acids with ectopic fat deposition and lipid panel. Methods: A single 3.0 Tesla magnetic resonance imaging scanner was employed to measure fat deposition in the pancreas, liver, and skeletal muscle in 76 adults. Blood samples were drawn to determine total bile acids and lipid panel. Linear regression analyses were run, taking into account age, sex, body mass index, and other covariates. Results:The studied ectopic fat depots were not significantly associated with levels of total bile acids in serum. Total bile acids were significantly associated high-density lipoprotein cholesterol -consistently in both the unadjusted (p = 0.018) and all adjusted models (p = 0.012 in the most adjusted model). Low-density lipoprotein cholesterol, total cholesterol, and triglycerides were not significantly associated with total bile acids in both the unadjusted and all adjusted models. Conclusion: Fat deposition in the pancreas, liver, and skeletal muscle is not associated with circulating levels of total bile acids. High-density lipoprotein cholesterol is the only component of lipid panel that is associated with total bile acids.

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“… 5 Intrapancreatic fat deposits are a precursor to pancreatic cancer in patients with pancreatitis. 8 Mean lipid and uric acid levels are significantly higher in patients with PS than in patients without PS. 9 The prevalence of PS is elevated in patients with hyperlipidemia.…”

Section: Introductionmentioning

confidence: 94%

“…Increasing evidence suggests that PS is associated with type 2 diabetes, metabolic syndrome, atherosclerosis, acute severe pancreatitis, and pancreatic cancer. , PS can be an initial indicator of “ectopic fat deposition,” which occurs before nonalcoholic fatty liver disease . Intrapancreatic fat deposits are a precursor to pancreatic cancer in patients with pancreatitis . Mean lipid and uric acid levels are significantly higher in patients with PS than in patients without PS .…”

Section: Introductionmentioning

confidence: 99%

Uric Acid Inhibits Mice Pancreatic Steatosis via the Glycerophospholipid Pathway

Xiao,

Han,

Wang

et al. 2024

ACS Omega

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Background: despite evidence for mutually reinforcing effects of serum uric acid (SUA) and lipids, the effects of uric levels on pancreatic steatosis are not well-established. In this study, the relationship between low concentrations of uric acid and pancreatic steatosis was evaluated. Methods: forty C57BL/6J mice were fed a diet of high uric acid (HU), high fat (HF), high uric acid and high fat (HUHF), and normal control (NC) (10 mice in each group). Weight was measured weekly. Ultrasonography was performed to observe the pancreatic echo intensity of all mice before the end of feeding. Subsequently, peripheral blood was taken for biochemical examination. Intact pancreatic tissues were taken, part of which was used for pathological examination, part of which was used for PCR experiments and Western Blot experiments to obtain glycerophospholipid-associated mRNA data and protein levels. Results: body weight was significantly higher in the HF group than in the other three groups. Higher uric acid matched lower total cholesterol and triglyceride, matched higher low-density lipoprotein, and matched equal high-density lipoprotein. Ultrasound images and HE staining of pancreatic tissues of mice showed that higher uric acid matched lower fat content. The mRNA levels of phospholipase A2 group IB were highest in high uric acid group, while relative protein expression levels were lowest in high uric acid and control groups. Phospholipase A2 group IIA showed the opposite patterns. Conclusions: elevated serum uric acid at low concentrations can inhibit pancreatic steatosis, which is modulated via the glycerophospholipid metabolic pathway.

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Intrapancreatic, Liver, and Skeletal Muscle Fat Depositions in First Attack of Acute Pancreatitis Versus Health

Cited by 14 publications

References 48 publications

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

Relationship of Serum Bile Acids with Fat Deposition in the Pancreas, Liver, and Skeletal Muscle

Uric Acid Inhibits Mice Pancreatic Steatosis via the Glycerophospholipid Pathway

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