Intraosseous Myelolipoma of Maxilla and Mandible

Intramedullary/intraosseous myelolipoma in a patient with pathologic fracture

“…In the reported cases, a variety of radiological findings were present but all were consistent with a low density or osteolytic lesion ranging from a hypodense foci to a tumoral mass (Table 1). Most patients presented with a single intraosseous lesion with the exception of the two cases on the maxilla and mandible which presented with multiple, wide lesions (Jaewon et al, 2019;Chiarini et al, 1992). Sundaram et al reported that the first reported Italian case of IOML did not have a pre-operative radiology study but in fact such a study was performed (Sundaram et al, 2007;Chiarini et al, 1992).…”

“…Myelolipoma is an infrequent benign mesenchymal tumor that is comprised of mature adipose tissue mixed with hematopoietic components and is usually found in the adrenal gland. Myelolipomas have been described in extra-adrenal sites such as the stomach, liver, mediastinum and kidneys but are extremely rare inside the bone (Sawhney et al, 2006;Kenney et al, 1998;Wood et al, 2013;Jaewon et al, 2019). The absence of hematopoetic elements differentiates myelolipomas from intraosseous lipomas.…”

“…Other locations are uncommon and mostly asymptomatic (Wen et al, 2015;Bokhari et al, 2020;Barman et al, 2014). Intra-osseous myelolipomas (IOML) are extremely rare with only 7 cases reported in the English and Non-English literature (Jaewon et al, 2019;Wen et al, 2015;Papapietro et al, 2009;Sundaram et al, 2007;Chiarini et al, 1992;Selye & Stone, 1950;Sakai et al, 2021). Considering the very low incidence of this tumor in bone, it is rarely considered in the differential diagnosis of intraosseous tumors.…”