Intraosseous hemangioblastoma of the cervical spine: case report

Li, Zhen; Curtis, Brian R.; Layser, Robert B.; Selvarajan, Santosh Kumar; Kenyon, Lawrence C.; Parsons, Theodore W.; Rubin, Asa

doi:10.3171/2017.3.spine1622

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…T here are only a few case reports (20 cases) on "intraosseous" cervical tumors, such as hemangioblastomas, malignant peripheral nerve sheath tumors, and schwannoma [3][4][5][6][7] . Although a few studies have reported IONF occurring in the mandible, humerus, and clavicle [8][9][10] , there is only 1 case (from 1960) of IONF reported in the cervical spine 11 .…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Intraosseous Neurofibroma in Cervical Spine

Iwai,

Nozawa,

Fushimi

et al. 2024

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Case: A 30-year-old man had cervical radiculomyelopathy and neck pain caused by a massive intraosseous neurofibroma (IONF) originating from the C6 vertebrae. We performed posterior tumor resection with spinal instrumentation and fusion from C3 to T2 and a follow-up resection procedure of the remaining C6 anterior tumor, sacrificing the affected vertebral artery (VA), which accordingly required bypass surgery at 2 months recovery. Reconstruction using a titanium mesh cage was successfully performed. There were no local recurrences at 2 years postoperatively. Conclusions: Total tumor resection split into 2 stages with sacrifice of the affected VA is a feasible option for treatment of IONF.

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Section: Discussionmentioning

confidence: 99%

Surgical Management of Intraosseous Neurofibroma in Cervical Spine

Iwai,

Nozawa,

Fushimi

et al. 2024

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“…Sporadic HBs are often isolated cases, rarely recur following a complete surgical resection, and are associated with a more severe neurological deficits. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Sporadic hemangioblastoma of cauda equina: A case report and brief literature review

Chaurasia¹,

Oria²,

Giraldi³

et al. 2022

J Craniovert Jun Spine

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Background Hemangioblastomas (HBs) are rare lesions accounting for 1%–5% of all spinal cord tumors, and are mostly associated with Von Hippel-Lindau (VHL) syndrome. Localization in the cauda equina is uncommon. Aim: In this manuscript, we aimed to describe a rare case of sporadic intradural extramedullary HB of the cauda equina and present a literature review. Mathods: A systematic research was performed on PubMed, MEDLINE, and Google Scholar, using the keywords “spinal HB” and “cauda equina tumors.” The previous literature is integrated by the description of the present case. A 49-year-old female presented in August 2020 to our institution with a magnetic resonance imaging (MRI) which showed an intradural mass at L1/2 level and angiography that showing a nidus of serpiginous vessels inside the lesion. Symptoms were right sciatica and paresthesia in right L5 radicular dermatome for more than 3 months. Neurological examination revealed claudicatio spinalis and hypoesthesia on right L5 dermatome and weakness of right anterior tibialis muscle. Microsurgical en bloc resection of lesion was performed with adjuvant neurophysiological intraoperative monitoring. The histological examination provided the diagnosis of HB. Results: After surgery, symptoms and neurological impairment gradually improved. Postoperative MRI showed no residual tumor. Conclusions: Although intradural extramedullary HB of the cauda equina without VHL syndrome is a rare pathological entity, this diagnosis must be taken in consideration when a mass affects cauda equina. Preoperative embolization is an option to minimize intraoperative bleeding. Radiosurgery seems to prevent recurrences when the tumor is not completely excised. A complete surgical removal of the lesion is usually possible and it leads to a low likelihood of recurrence.

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“…Hemangioblastomas are vascular neoplasms that account for 1%–3% of all central nervous system (CNS) tumors and are usually present in the cerebellum, brainstem, or spinal cord. 1–4 Although the majority of spinal hemangioblastomas are located in the cervical and thoracic regions, 1 , 5–13 they have also been reported in the lumbar and sacral spine, 5 cauda equina, 2 , 14 , 15 and filum terminale. 16 , 17 Few cases have been described in 18–24 or at the level of 25–27 the conus medullaris.…”

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confidence: 99%

“… 2 , 7 , 28 , 29 A total of 70%–80% of spinal cord lesions arise sporadically, whereas the remainder are associated with von Hippel-Lindau syndrome. 1 , 3 , 11 , 30 von Hippel-Lindau syndrome is a tumor suppressor gene syndrome marked by mutations in the VHL gene in the chromosome 3p25–26 region. 10 , 30 It is transmitted in an autosomal dominant manner and is associated with several pathological conditions, including CNS tumors (hemangioblastomas, retinal angiomatosis, endolymphatic sac tumors), renal cell carcinoma/cysts, pancreatic carcinomas/cysts, pheochromocytomas, and epididymal cystadenomas.…”

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Intradural, extramedullary hemangioblastoma at the level of the conus medullaris: illustrative case

Shields

Harpring

Highfield

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUND Hemangioblastomas are rare, slow-growing, and highly vascularized tumors that typically occur in the cerebellum and spinal cord. The cervical and thoracic regions are the most common spinal sites, and the tumors are usually intramedullary. OBSERVATIONS The authors report the case of a man whose chest computed tomography performed for managing coronavirus disease 2019 incidentally revealed an enhancing area in the spinal canal at T12–L1. The patient reported low back pain as well as leg numbness and tingling. Magnetic resonance imaging of the lumbar region with and without gadolinium contrast demonstrated an intradural, extramedullary lesion with displacement of the conus medullaris. The differential diagnosis included a schwannoma and myxopapillary ependymoma. Bilateral T12–L1 laminectomies were performed with resection of the mass. The general pathologist rendered the frozen section diagnosis of a spindle cell neoplasm, suggesting the differential diagnosis of schwannoma or myxopapillary ependymoma. Immunohistochemistry was positive for inhibin, GFAP, reticulin, CD31, SOX-10, S100, and EMA. A World Health Organization grade 1 hemangioblastoma was confirmed. LESSONS Spinal surgeons should be cognizant of the presenting symptoms and differential diagnosis of hemangioblastomas at the level of the conus medullaris, especially when the tumor is diagnosed incidentally. Additional investigations should be performed to determine whether von Hippel-Lindau syndrome is associated with the hemangioblastoma, as this combination portends a different clinical presentation, multiple tumor locations, and tumor recurrence following resection.

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Intraosseous hemangioblastoma of the cervical spine: case report

Cited by 5 publications

References 17 publications

Surgical Management of Intraosseous Neurofibroma in Cervical Spine

Surgical Management of Intraosseous Neurofibroma in Cervical Spine

Sporadic hemangioblastoma of cauda equina: A case report and brief literature review

Intradural, extramedullary hemangioblastoma at the level of the conus medullaris: illustrative case

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