Intraoral pyogenic granuloma after allogeneic bone marrow transplant

Lee, Linda; Miller, Pierre A.; Maxymiw, W.G.; Messner, Hans A.; Rotstein, Lorne

doi:10.1016/0030-4220(94)90173-2

Cited by 42 publications

(35 citation statements)

References 10 publications

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“…Oral mucosa involvement may be the sole finding in chronic GVHD. Sicca syndrome of the eyes and the mouth can be seen and pyogenic granuloma formation has been reported as a rare finding (1,4,21,33). Oral mucosa involvement was present in 60.9% of our chronic GVHD patients and six patients had only mucosal lesions without any skin involvement.…”

Section: Discussionmentioning

confidence: 71%

Clinical Manifestations of Cutaneous Graft-versus-host Disease after Allogeneic Haematopoietic Cell Transplantation: Long-term Follow-up Results in a Single Turkish Centre

Şanlı¹,

Ekmekçı²,

Arat³

et al. 2004

Acta Dermato-Venereologica

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The aim of this study was to evaluate the clinical manifestations of cutaneous graft-versus-host disease (GVHD) developed after allogeneic haematopoietic cell transplantation. In all, 67 patients were evaluated: 49 patients developed acute GVHD, 17 patients developed de novo chronic GVHD and 29 developed secondary chronic (15 limited, 14 progressive) GVHD following acute cutaneous GVHD. Of the 46 patients with chronic GVHD, lichenoid lesions were observed in 32 and sclerodermoid lesions were observed in 12. In four patients with sclerodermoid cutaneous GVHD, these lesions occurred after a lichenoid phase. Oral lesions were present in 61% of the patients and six of them had only oral mucosal involvement without any skin lesions. Nail lesions were observed in 31% of the patients. During the follow-up period 15 patients with GVHD died and in 7 of them the cause of death was related to chronic GVHD. In conclusion, GVHD has a wide spectrum of cutaneous manifestations, which can be used as an important tool for the early diagnosis of the disease.

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Section: Discussionmentioning

confidence: 71%

Clinical Manifestations of Cutaneous Graft-versus-host Disease after Allogeneic Haematopoietic Cell Transplantation: Long-term Follow-up Results in a Single Turkish Centre

Şanlı¹,

Ekmekçı²,

Arat³

et al. 2004

Acta Dermato-Venereologica

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“…Numerous studies have investigated the immediate effects of chemotherapy and/or radiation on the oral mucosa and other perioral soft tissues, [1][2][3][4][5][6][7][8][9][10][11][12] but few have addressed late dental sequelae of cancer treatment received at an early age. Nasam, 13 Kaste et al [14][15][16] observed hypodontia, microdontia, enamel hypoplasia, root stunting, taurodontia, over-retention of primary teeth, and an increased caries index in survivors of childhood cancer.…”

Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:The purpose of our study was to describe the types and frequencies of altered dental development in pediatric patients preparing for bone marrow transplantation (BMT). Retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000 for whom pre-BMT dental examination and panoramic radiography records were available. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, and pulpal calcifications. The 259 patients identified (150 male and 109 female) had a median age of 12.82 years (range, 3.18-25.93 years) at the time of BMT. In total, 203 were Caucasian, 38 were African-American, and 18 were of other races. In all, 150 (57.9%) had abnormal dentition. The most common dental abnormalities were caries (n ¼ 84), pulpal calcifications (n ¼ 34), and dental extractions (n ¼ 33). Developmental abnormalities occurred less frequently: taurodontia (n ¼ 8), hypodontia (n ¼ 10), microdontia (n ¼ 11), and root stunting (n ¼ 11). Dental abnormalities are prevalent in children undergoing BMT. Pre-transplant oral hygiene and dental examination should be standard care in order to minimize potential sites of infection.

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“…Other mucosal lesions that have been associated with chronic oral GVHD are "pyogenic granulomas" (Woo et al, 1996;Gehrke et al, 1986, Lee et al, 1994 and verruciform xanthoma (Allen and Kapoor, 1993). These may be incidental findings, although, hypothetically, the occurrence of "pyogenic granulomas" may be associated with cyclosporine use, since cyclosporine has a significant effect on connective tissue homeostasis, and this effect, coupled with increased tissue turnover at sites of chronic GVHD, may predispose to their occurrence.…”

Section: (B) Oral Presentationmentioning

confidence: 99%

Graft-vs.-Host Disease

Woo

Lee

Schubert

1997

Critical Reviews in Oral Biology & Medicine

130

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Bone marrow transplantation (BMT) is the treatment of choice for many leukemias, lymphomas, bone marrow failure syndromes, and immundeficiency disorders, and is the primary and salvage therapy for many solid malignancies. With the establishment of national and international marrow banks, unrelated allogeneic BMT is being performed with increasing frequency. Graft-vs.-host disease (GVHD) remains a major complication of allogeneic BMT, occurring in 25% to 70% of patients despite GVHD prophylaxis, with the skin, gastro-intestinal tract, and liver as primary target organs. Oral findings are seen in both acute and chronic GVHD. In acute GVHD, the oral lesions are often painful, erythematous, ulcerative, and desquamative. In chronic GVHD, they are lichenoid with associated erythema and ulcerations; additionally, they may be associated with a sicca syndrome characterized by xerostomia and progressive salivary gland atrophy. General principles of BMT are discussed, as are systemic and local therapeutic options for oral GVHD.

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Intraoral pyogenic granuloma after allogeneic bone marrow transplant

Cited by 42 publications

References 10 publications

Clinical Manifestations of Cutaneous Graft-versus-host Disease after Allogeneic Haematopoietic Cell Transplantation: Long-term Follow-up Results in a Single Turkish Centre

Clinical Manifestations of Cutaneous Graft-versus-host Disease after Allogeneic Haematopoietic Cell Transplantation: Long-term Follow-up Results in a Single Turkish Centre

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Graft-vs.-Host Disease

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