Intraoral granulocytic sarcoma presenting as multiple maxillary and mandibular masses: A case report and literature review

Xie, Zhenrong; Zhang, Feng; Song, En; Ge, Weili; Zhu, Fengsen; Hu, Jian

doi:10.1016/j.tripleo.2006.12.028

Cited by 24 publications

(35 citation statements)

References 17 publications

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“…The occurrence of intraoral MS as multiple masses involving multiple sites is extremely rare, with only 2 reported cases in the literature 3,8 . Intraoral MS usually occurs concomitantly with or subsequent to the development of AML; it is most seen in patients with the subtype AML-M1 (myeloblastic leukaemia without maturation) or AML-M2 (myeloblastic leukaemia with maturation) 5 , whereas rarely, it precedes the appearance of AML as in our case.…”

Section: Discussionmentioning

confidence: 99%

“…The lesion occurs more often in women; the age of affected patients ranges widely (3 to 89 years) 11 . The maxillary and mandibular gingivae were the most common sites involved, followed by the palate and very rarely the cheek 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore additional immunohistochemical studies may help in reaching to a definitive diagnosis because myeloid cells are reactive to antibodies against lysozyme, myeloperoxidase and chloroacetate esterase. Also MS myeloblasts usually express myeloid-associated antigens such as CD43, but are not reactive with lymphoid antigens 3 . In addition, immunophenotyping with flow cytometry and cytogenetics may contribute to a definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…MS can occur during the course of acute or chronic myeloid leukaemia, and myelodysplastic syndromes. In the vast majority of the reported cases, only one site was involved with a single intraoral MS lesion, and the cases predominantly associated with acute myeloid leukaemia (AML) 3 . Rarely, MS is possible to appear months before the AML manifests, during the course of the illness or represent a leukaemia relapse or remission 4 .…”

Section: Introductionmentioning

confidence: 99%

“…The involvement sites of MS are highly variable and has been reported to affect the skin, bones, upper respiratory tract, and gastrointestinal tract including the oral cavity 3,5 . Furthermore it has been reported that in 16% of MS cases were diagnosed in the head and neck region, although intraoral MS rarely occurs 6 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Intraoral Myeloid sarcoma with bilateral involvement: Case report

Poulopoulos¹,

Iordanidis²,

Andreadis³

et al. 2017

Balkan J Dent Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intraoral Myeloid sarcoma with bilateral involvement: Case report

Poulopoulos¹,

Iordanidis²,

Andreadis³

et al. 2017

Balkan J Dent Med

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Case of pediatric acute promyelocytic leukemia presenting as extramedullary tumor of the mandible

Yamashita¹,

Isomura²,

Hamasaki³

et al. 2012

Head & Neck

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Acute Myeloid Leukaemia Diagnosed by Intra-Oral Myeloid Sarcoma. A Case Report

Papamanthos

Kolokotronis

Skulakis

et al. 2010

Head and Neck Pathol

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Myeloid sarcoma (MS) is a rare extramedullary malignant tumor composed of immature myeloid cells. It is strongly associated with a well known or covert acute myeloid leukaemia, chronic myeloproliferative diseases or myelodysplastic syndromes. Intraoral MS scarcely occurs. An unusual case of acute myeloid leukaemia, which was diagnosed by mandibular MS that was developed in the alveolar socket after a dental extraction, is reported. The histological examination (including immunohistochemical analysis) of a subsequent biopsy showed infiltration of the oral mucosa by neoplastic cells. This lesion was therefore classified as acute myeloid leukaemia. The patient was referred to oncologists that confirmed the initial diagnosis. The patient underwent chemotherapy and the mandibular tumor disappeared. Forty days later, a relapse of the disease, which appeared as a great-ulcerated lesion, was developed in the hard palate. Thirty days after the second chemotherapy had finished, a new intraoral tumor was developed in the vestibular maxillary gingiva. Review of the literature shows no report of intraoral relapse and particularly multiple relapse of a MS that involves the oral cavity. Even though MS is encountered infrequently in the oral cavity, it should be considered in the differential diagnosis of conditions (especially tumors) with a similar clinical appearance.

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Intraoral granulocytic sarcoma presenting as multiple maxillary and mandibular masses: A case report and literature review

Cited by 24 publications

References 17 publications

Intraoral Myeloid sarcoma with bilateral involvement: Case report

Intraoral Myeloid sarcoma with bilateral involvement: Case report

Case of pediatric acute promyelocytic leukemia presenting as extramedullary tumor of the mandible

Acute Myeloid Leukaemia Diagnosed by Intra-Oral Myeloid Sarcoma. A Case Report

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