Intraoral effects of a fluoride-releasing device on acid-softened enamel

Corpron, Richard E.; Clark, James W.; Tsai, Anthony; More, Frederick G.; Merrill, D.; Kowalski, Charles J.; Tice, Thomas R.; Rowe, Cathy E.

doi:10.14219/jada.archive.1986.0202

Cited by 35 publications

(27 citation statements)

References 20 publications

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“…As can be seen, the %SMHR increases as values for R decrease. Meanwhile, the %RER was calculated according to the method of Corpron et al [1986] as follows: %RER = 100[(E1 -E2)/(E1 -B)]. As the erosion resistance increases, E2 becomes smaller and the %RER less negative or positive.…”

Section: Determination Of %Smhr and %Rermentioning

confidence: 99%

Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ: A Randomized Clinical Trial

Nehme¹,

Jeffery²,

Mason³

et al. 2016

Caries Res

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eter was noted between the fluoride treatment groups. Increasing numerical improvements of %SMHR and %RER were observed in all four treatment groups over time (2, 4, and 8 h). The present in situ model is a sensitive tool to investigate intrinsic and fluoride-enhanced rehardening of eroded enamel. All three fluoride toothpastes were more efficacious than placebo, and there were no safety concerns following single dosing in this short-term in situ model. Dental erosion is described as the progressive loss of tooth substance as a result of chemical processes that, unlike those in caries pathology, do not involve bacteria [Layer, 2009;Mason, 2009]. Also unlike caries, which has seen a declining prevalence in western countries, the incidence of dental erosion has been reported to be on the increase [Truin et al., 2004;Chadwick, 2006;Toumba, 2006], and the condition has been highlighted as 'a challenge for the 21st century' [Angmar- Månsson, 2006]. The beneficial effects of fluoride dentifrices for the prevention and management of dental erosion have been evidenced in a large number of in vitro and in situ studies [Bartlett et al., 1994;Attin et al., 1998;Ganss et al., 2001;van Rijkom et al., 2003;Ganss et al., 2004;Hughes et al., 2004; Key Words Dental erosion · Fluoride · Gel-to-foam toothpaste · In situ model · Surface microhardness AbstractThis single-center, randomized, placebo-controlled, fourtreatment, four-period crossover study compared the enamel remineralization effects of low-and medium-abrasivity gel-to-foam toothpastes and a reference toothpaste (all 1,450 ppm fluoride as NaF) versus placebo toothpaste (0 ppm fluoride) using a short-term in situ erosion model. Subjects (n = 56) wearing a palatal appliance holding acidsoftened bovine enamel specimens brushed their teeth with the test toothpastes. Thereafter, the specimens were removed for analysis of percent surface microhardness recovery (%SMHR) and percent relative erosion resistance (%RER) at 2, 4, and 8 h. Both low-and medium-abrasivity gel-to-foam fluoride toothpastes and the reference toothpaste provided significantly greater %SMHR than placebo at all assessment time points (all p < 0.05). No statistically significant difference of %SMHR was observed between the fluoride treatment groups at any time point. Similarly, all fluoride products provided significantly superior %RER versus placebo (all p < 0.0001), whereas no significant difference of this param-

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Section: Determination Of %Smhr and %Rermentioning

confidence: 99%

Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ: A Randomized Clinical Trial

Nehme¹,

Jeffery²,

Mason³

et al. 2016

Caries Res

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show abstract

“…Available evidence shows clearly that the cariostatic effect of fluoride is heavily dependent on its ambient levels in the mouth (Larson and Mellberg, 1977;Mirth et al , 1982Mirth et al , , 1983Corpron et al , 1986). These observations suggest that low levels of fluoride constantly present in the mouth are critical for the expression of its maximum effect (Duckworth et al , 1987;Meyerowitz and Watson, 1998).…”

Section: Enhancing the Effects Of Fluoridementioning

confidence: 99%

Do We Need to be Concerned about Dental Caries in the Coming Millennium?

Bowen

2002

Critical Reviews in Oral Biology & Medicine

201

109

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ABSTRACT:Dental caries continues to be a pubic health problem despite claims that 50% of schoolchildren are caries-free. There are widespread variations in the prevalence of caries worldwide. Caries lesions are the clinical manifestation of a pathogenic process that may have been occurring on the tooth surface for months or years. Acid production by bacteria embedded in a biofilm termed "dental plaque" is a key aspect of the pathogenesis of dental caries; nevertheless, the ability of micro-organisms to survive in a hostile acid milieu and the influence of fluoride and additional agents on this acid tolerance receive scant attention. Study of cariogenic micro-organisms largely has been limited to observations made on them in the planktonic state; clearly dental caries is essentially a surface phenomenon, and micro-organisms behave distinctively when grown on a surface. Although significant progress has been made in our understanding of the etiology, pathogenesis, and prevention of dental caries, it still remains a scientific and clinical enigma worthy of the attention of the best scientists.

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“…The 0.035-mg F/day FRD was used in this study for regimen C, and the 0.116-mg F/day FRD was used for regimens D and E. The basic structure o f FRDs has previously been described by Corpron et al [1986]. For regimens C. D. and E. the FRDs were bonded directly bilaterally on the buccal surfac es o f the first or second maxillary molars with a chemically activated bonding composite (Rely-Bond; Reliance Orthodontic Products, Itas ca, 111.. USA).…”

Section: Intraoral Proceduresmentioning

confidence: 99%

“…While a variety of topical fluoride agents used intermittent ly (i.e., dentifrices, mouthrinses, and gels) provided tempo rary elevations of salivary fluoride levels [Bruun et a!., 1982[Bruun et a!., , 1984Fleintze and Petersson, 1979], the continuous release o f fluoride from intraoral fluoride-releasing devices (FRD) has been demonstrated to provide significant sustained ele vation of salivary fluoride levels for prolonged periods [Mirth et al, 1982;Kula et al, 1987] and to enhance remin eralization of early enamel lesions in situ [Corpron et al, 1986[Corpron et al, , 1992, The range o f fluoride release rates in previous studies of salivary fluoride was 0.04-1.0 and 0.5 mg F/day in the previous remineralization studies. It is the purpose of this study to perform a dose-related study of remineraliza tion of early enamel lesions in situ, comparing mineral den sity changes of two FRDs of different release rates to a pla cebo-treated control and a clinically proven NaF dentifrice.…”

mentioning

confidence: 99%

Dose Related Remineralization Using Intraoral Fluoride-Releasing Devices in situ

Cain

Corpron²,

Fee³

et al. 1994

Caries Res

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Dose-related remineralization of enamel lesions was studied in situ. Enamel specimens with subsurface lesions were mounted on lower molars bilaterally and exposed to five regimens: (A) control with a F-free dentifrice three times daily; (B) NaF dentifrice brushed three times daily; (C) fluoride-releasing device (FRD; 0.07 mg F/day release rate) plus F-free dentifrice; (D) FRD (0.232 mg F/day) plus F-free dentifrice, F/day and (E) FRD (0.232 mg/F/day) plus NaF dentifrice. Resting and stimulated saliva samples were obtained for salivary flow and F content determinations. Twenty-eight subjects participated in this double-blind, random-assignment crossover study. After 50 days the enamel specimens were recovered, sectioned, microradiographed, and scanned with image analysis. Regimens D and E demonstrated approximately 30% additional remineralization as compared with to controls, and regimens B and C showed 13.7 and 10.5% increased remineralization as compared with to controls. The increased remineralization of the regimens generally paralleled the increase in salivary F and clearly demonstrated a dose-related response which was some threefold in relation to release rate, salivary F, and percent remineralization.

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Intraoral effects of a fluoride-releasing device on acid-softened enamel

Cited by 35 publications

References 20 publications

Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ: A Randomized Clinical Trial

Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ: A Randomized Clinical Trial

Do We Need to be Concerned about Dental Caries in the Coming Millennium?

Dose Related Remineralization Using Intraoral Fluoride-Releasing Devices in situ

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