Intraoral ecchymosis in myelodysplastic syndrome with myelofibrosis: A case report

Abstract

Myelodysplastic syndrome (MDS) with myelofibrosis having intraoral manifestations as ecchymosis, unprompted gingival bleeding, and generalized gingival overgrowth with associated periodontal disease is one of the rare cases. MDS is a clonal disorder of pluripotent hematopoietic stem cells. Myelofibrosis is a disorder where normal bone marrow is replaced with a fibrous scar tissue. It is a complication of MDS. Here, we are discussing a rare case report of MDS with myelofibrosis manifesting as intraoral ecchymosis. MDS with myelofibrosis is aggressive disorder of elderly whose pathophysiology remains unknown with a poor prognosis. When myelofibrosis is observed in a bone marrow specimen, further investigation of the patient with respect to splenomegaly, leukocyte count, peripheral blood smear and bone marrow findings, and karyotype will serve as a guide to correct diagnosis.