Intraoral Drug Delivery Microsystem

Schumacher, Axel; Goettsche, T.; Haeberle, S.; Velten, Thomas; Scholz, Oliver; Wolff, Ändy; Beiski, Ben Z.; Messner, S.; Zengerle, Roland

doi:10.1007/978-3-540-89208-3_564

Cited by 1 publication

(4 citation statements)

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“…Intracerebral delivery: microprobes with microfluidic channels for controlled drug infusion [264] Intracochlear delivery: a microfluidic reciprocating delivery device with a single microcannula to release drug to the cochlea [270] Intraoral delivery: a mechatronic device as part of a dental prosthesis for drug release through the buccal mucosa [271,272] Vaginal/intrauterine delivery…”

Section: Punctal Plugsmentioning

confidence: 99%

“…[97] Drug release from the above devices is through a diffusion manner after the device outlet is opened remotely, while pump-like release mechanisms allow a quicker release by pumping drug solutions out in a short time. [271,272] Reproduced with permission. In the button-like device ( Figure 3D), [104,105] PDMS was incorporated with magnetic microparticles, forming a magnetic membrane to seal the drug-containing reservoir.…”

Section: Pulsatile Delivery Devicesmentioning

confidence: 99%

“…By incorporating magnetic materials with soft PDMS membranes, Chiao and coworkers have developed various microdevices for on-demand release of drugs with remotely controlled magnetic fields. [272] Copyright 2009, Springer. When the membrane deflected under external magnetic fields, the drug was released through a microaperture at the center of the membrane.…”

Section: Pulsatile Delivery Devicesmentioning

confidence: 99%

“…This drug delivery strategy not only ensures in zero net volume transfer to protect the delicate structures in ear from damaging changes in perilymph volume and pressure, but also achieves effective drug delivery through the diffusion and mixing of the high concentrated drug with perilymph. [271,272] It is an assembly of a drug reservoir, an electronic control system, sensors, power supply, microvalves, and an osmotic pump. [270] Intraoral Delivery: Dental delivery systems today are used for the local treatment of diseases affecting the oral cavity itself (e.g., periodontitis or fungal infections), or for systemic drug delivery through the buccal mucosa.…”

Section: Devices Applied To Specific Sitesmentioning

confidence: 99%

See 3 more Smart Citations

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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Section: Punctal Plugsmentioning

confidence: 99%