Intraoperative sonography for nonpalpable breast lesions: Additional indications for a consolidate technique

Famà, Fausto; Maria, Alessandra Di; Cicciù, Marco; Buccheri, Giancarlo; Gioffré-Florio, Maria; Benvenga, Salvatore; Sindoni, Alessandro

doi:10.1111/tbj.13575

Cited by 4 publications

(1 citation statement)

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“…Among orbital tumors, metastatic lesions show a prevalence of 1%‐13% 8 . Breast carcinoma, the most frequent cancer in the female gender, 9‐12 is also the most common malignancy causing orbital metastases 13‐15 . Incidence of orbital metastases from breast cancer in our study was 0.13%, but it may be underestimated in the presence of involvement of major organs like lungs, liver or bone, which can dominate the patients' clinical condition.…”

Section: Discussionmentioning

confidence: 57%

Orbital metastases from breast cancer: A single institution case series

Sindoni

Famà

Vinciguerra

et al. 2020

Journal of Surgical Oncology

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Background and Objectives Among orbital tumors, metastatic lesions have a prevalence of 1% to 13%; on the other hand, breast cancer is the most common malignancy causing orbital metastases. The aim of this study is to present our experience dealing with orbital metastases caused by breast cancer, to assess characteristics and clinic‐pathological data of patients suffering from this rare occurrence and to find indexes related with their prognosis and survival. Methods Records of 28 patients diagnosed with orbital metastases from breast cancer at the Department of Ophthalmology, Humanitas Clinical and Research Centre of Milano over a 27‐year period (1992‐2018) were retrieved and analyzed. Results Mean patients' age at breast cancer diagnosis was 56.29 ± 14.63 years. Mean time interval between breast cancer diagnosis and orbital metastasis occurrence was 5 ± 4.17 years. All lesions were estrogen receptor‐positive; 79% of patients harbored progesterone receptor‐positive lesions. Interestingly, the majority of deceased patients presented orbital lesions with MIB‐1 index >50% (P = .0265) and had concomitant lung metastases (P = .0452). Conclusions The occurrence of orbital metastasis from breast cancer represents a challenging finding. Patients' clinical picture can include exophthalmos, edema, tumefaction, proptosis and/or diplopia. Significant symptomatic improvement can be achieved through surgery and other adjuvant treatments, such as radiation therapy and chemotherapy.

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Section: Discussionmentioning

confidence: 57%