Intraoperative sentinel lymph node mapping in patients with colon cancer

Paramo, Juan C.; Summerall, Janna; Wilson, Christopher L.; Cabral, A. Vieira; Willis, Irvin; Wodnicki, Henry; Poppiti, Robert; Mesko, Thomas W.

doi:10.1016/s0002-9610(01)00658-4

Cited by 54 publications

(48 citation statements)

References 20 publications

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“…The literature search identified 17 studies, 15 describing SLN mapping using blue dye 16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31] and two describing SLN mapping using a combination of blue dye and radiocolloid. 9,32 For one study that used both blue dye and radiocolloid in the first few cases, but, since the same SLNs were identified with both tracers, subsequently only used blue dye in the remaining cases, the reported results were ascribed to blue dye only.…”

Section: Resultsmentioning

confidence: 99%

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Sentinel Lymph Node Mapping in Colon Cancer: Current Status

et al. 2007

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Background: The primary role of sentinel lymph node (SLN) mapping in colon cancer is to increase the accuracy of nodal staging by identifying those lymph nodes with the greatest potential for harbouring metastatic disease. Ultrastaging techniques aim to identify the otherwise undetected metastases. Until now, no consensus exists as to the most optimal procedure in patients with colon cancer.Methods: A systematic literature search on the value of different SLN mapping techniques in patients with colon cancer was performed using the electronic search engine PubMed. Prospective studies published before 1 December 2005 were included and further articles were selected by cross-referencing. The results of different techniques using either blue dye or radiocolloid, were investigated.Results: The literature search yielded 17 relevant articles. SLN mapping using blue dye was described in 15 studies. Two studies reported the results of SLN mapping using a combination of blue dye and radiocolloid. The reported results on identification rate varied between 71 and 100%. Accuracy rates were between 78 and 100%, sensitivity rates between 25 and 100% and true upstaging rates between 0 and 26%. The results were not affected by the addition of radiocolloid to blue dye.Conclusions: Sentinel lymph node mapping in patients with colon cancer remains an experimental procedure with varying results. Further evaluation may lead to a standardized technique that offers the potential for significant upstaging of stage II patients. This may have important implications as to tailor adjuvant chemotherapeutic regimens in these patients.

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Section: Resultsmentioning

confidence: 99%

“…9,16,[18][19][20][21][22][23][24][25][26][27][28]31 Immunohistochemical staining was carried out using antibodies against cytokeratin (CK) and in one study against carcinoembryonic antigen (CEA). 23 The use of RT-PCR was only described in one study.…”

Section: Pathological Analysismentioning

confidence: 99%

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

et al. 2007

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“…Since 1999 numerous papers on the SN technique in colorectal cancer have been published, with a wide range of results in terms of accuracy and false negatives: False-negative rates in fact vary from 0% to 60% [26][27][28][29][30][31][32][33][34][35][36]. This astonishing range has several explanations.…”

Section: Discussionmentioning

confidence: 99%

Technique of sentinel lymph node biopsy and lymphatic mapping during laparoscopic colon resection for cancer

Bianchi¹

2015

ecancer

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“…The lack of standardization of the SLNM procedure results in different study group characteristics, resulting in heterogeneous accuracy (10) . Sensitivity has been revealed to be as low as 38% (4) and as high as 100% (9) , with identification rates ranging from 58% (3) to 100% (7) and false negatives from 0% (7) to 60% (6) . A precise definition of patients to be submitted to SLNM might also affect positively in the method's upstaging rate.…”

Section: Discussionmentioning

confidence: 99%

Suggestion of optimal patient characteristics for sentinel lymph node mapping in colorectal adenocarcinoma

Quadros¹,

Lopes

Araujo³

2010

Arq. Gastroenterol.

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-Context -In a previously published study, the variables lower rectal tumor site, preoperative chemoradiotherapy and large tumors were considered as independent risk factors for the inability of sentinel lymph node identification in patients with colorectal adenocarcinoma. Objectives -To determine if these variables could interfere in the precision and upstaging benefit of sentinel lymph node mapping in colorectal cancer. Methods -A database composed of 52 patients submitted to lymphatic mapping using technetium-99m-phytate and patent blue was reviewed. Only patients with tumors smaller than 5.0 cm, not submitted to preoperative chemoradiotherapy and without lower rectal cancer were included. Results -With these parameters, 11 patients remained to be studied. The sentinel lymph node identification rate was 100%, with a sensitivity of 100%, negative predictive value of 100%, no false negatives and accuracy of 100%. Sentinel lymph nodes were the only metastatic nodes in 36.4% of the patients, micrometastases (<0.2 cm or only identified by immunohistochemistry) provided an upstaging rate of 27.1% and metastases an upstaging rate of 9.1%. Conclusion -The parameters proposed in this study for selection of colorectal adenocarcinoma patients to be submitted to sentinel lymph node mapping identified optimal accuracy and good upstaging results. As the number of included patients was low, these results could serve as guidance for proper patient selection in further prospective lymph node mapping studies in colorectal cancer patients. HEADINGS -Colorectal neoplasms. Adenocarcinoma. Neoplasm staging. Sentinel lymph node biopsy.

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Intraoperative sentinel lymph node mapping in patients with colon cancer

Cited by 54 publications

References 20 publications

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

Sentinel Lymph Node Mapping in Colon Cancer: Current Status

Technique of sentinel lymph node biopsy and lymphatic mapping during laparoscopic colon resection for cancer

Suggestion of optimal patient characteristics for sentinel lymph node mapping in colorectal adenocarcinoma

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