Intraoperative Seizures Presenting as Refractory Hypotension

Vimala, Smita; Prathapadas, Unnikrishnan; Gautham, Nodu Shivananda

doi:10.1097/ana.0000000000000268

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2017

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“…Unfortunately, the interrelationship between hypotension and seizure has always been neglected. In a rare case of seizure presenting as refractory hypotension, the authors provided sufficient evidence to support acute hypotension as an atypical manifestation of seizure 16. Hypotension during the onset of seizure may cause cerebral hypoperfusion and further worsen autonomic dysfunction 16…”

Section: Discussionmentioning

confidence: 96%

Convulsive syncope related to a small dose of quetiapine in an adolescent with bipolar disorder

Lai

Huang

et al. 2017

NDT

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Quetiapine, an atypical antipsychotic, has been extensively used in patients with bipolar disorder. Overdose of quetiapine can result in severe complications, such as coma, seizure, respiratory depression, arrhythmia, and even death. However, the paucity of toxicological evaluation in adolescence causes more potential risks in this population. Herein, we present a case of hypotension and convulsive syncope after exposure to a small dose of quetiapine in a 16-year-old who was diagnosed with bipolar disorder. After cessation of quetiapine, no additional convulsive movements were reported. This case indicates that even in young patients without predisposing factors, close monitoring of adverse effects should be warranted for safety concerns, especially at the initiation of quetiapine treatment.

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Section: Discussionmentioning

confidence: 96%