Intraoperative Radiotherapy During Radical Prostatectomy for Locally Advanced Prostate Cancer: Technical and Dosimetric Aspects

Krengli, Marco; Terrone, Carlo; Ballarè, Andrea; Loi, G.; Tarabuzzi, R.; Marchioro, G.; Beldì, Debora; Monès, E.; Bolchini, Cesare; Volpe, Alessandro; Frea, Bruno

doi:10.1016/j.ijrobp.2009.03.037

Cited by 27 publications

(30 citation statements)

References 20 publications

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“…In the Italian series, surgical complications, such as haematoma and lymphocele, occurred with a similar incidence to that of conventional prostatectomy [53–56]. No major surgical complications were described and patients had no significant difference of estimated blood loss and need of transfusion.…”

Section: Prostate Cancermentioning

confidence: 99%

“…Among 14 IORT literature studies, 9 clinical series and the ISIORT registry were selected and presented in Table 4 [2, 53–61]. …”

Section: Prostate Cancermentioning

confidence: 99%

“…More recent experiences were reported by Italian authors using IORT in combination with radical prostatectomy and regional lymph node dissection before or after the surgical procedure [53–56]. A relevant percentage (81%) of patients was included in prospective institutional study protocols as described in the ISIORT data-registry [2].…”

Section: Prostate Cancermentioning

confidence: 99%

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Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

et al. 2017

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Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in gynaecological and genito-urinary cancer including endometrial, cervical, renal, bladder and prostate cancers.Literature search was performed by Pubmed and Scopus, using the words “intraoperative radiotherapy/IORT”, “gynaecological cancer”, “uterine/endometrial cancer”, “cervical/cervix cancer”, “renal/kidney cancer”, “bladder cancer” and “prostate cancer”. Forty-seven articles were selected from the search databases, analyzed and briefly described.Literature data show that IORT has been used to optimize local control rate in genito-urinary tumours mainly in retrospective studies. The results suggest that IORT could be advantageous in the setting of locally advanced and recurrent disease although further prospective trials are needed to confirm this findings.

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Section: Prostate Cancermentioning

confidence: 99%

“…Among 14 IORT literature studies, 9 clinical series and the ISIORT registry were selected and presented in Table 4 [2, 53–61]. …”

Section: Prostate Cancermentioning

confidence: 99%

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Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

et al. 2017

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“…Detectors based on metal oxide semiconductor field-effect transistors (MOSFETs) [6][7][8][9] and radiochromic films [10,11] have been investigated for these purposes. MOSFETs can be used as dosimeters when appropriately operated [12][13][14].…”

mentioning

confidence: 99%

“…Krengli et al [11] presented a study of 38 patients with locally advanced prostate cancer irradiated with a Mobetron mobile linac. Film dosimetry focused on measuring absorbed dose to the rectum.…”

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confidence: 99%

In vivo dosimetry in intraoperative electron radiotherapy

et al. 2014

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Commissioning, clinical implementation, and performance of the Mobetron 2000 for intraoperative radiation therapy

Wootton

Meyer

Kim

et al. 2017

J Applied Clin Med Phys

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The Mobetron is a mobile electron accelerator designed to deliver therapeutic radiation dose intraoperatively while diseased tissue is exposed. Experience with the Mobetron 1000 has been reported extensively. However, since the time of those publications a new model, the Mobetron 2000, has become commercially available. Experience commissioning this new model and 3 years of data from historical use are reported here. Descriptions of differences between the models are emphasized, both in physical form and in dosimetric characteristics. Results from commissioning measurements including output factors, air gap factors, percent depth doses (PDDs), and 2D dose profiles are reported. Output factors are found to have changed considerably in the new model, with factors as high as 1.7 being measured. An example lookup table of appropriate accessory/energy combinations for a given target dimension is presented, and the method used to generate it described. Results from 3 years of daily QA measurements are outlined. Finally, practical considerations garnered from 3 years of use are presented.

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Intraoperative Radiotherapy During Radical Prostatectomy for Locally Advanced Prostate Cancer: Technical and Dosimetric Aspects

Cited by 27 publications

References 20 publications

Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

In vivo dosimetry in intraoperative electron radiotherapy

Commissioning, clinical implementation, and performance of the Mobetron 2000 for intraoperative radiation therapy

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