Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies

Pearson, A. Scott; Izzo, Francesco; Fleming, Rachel; Ellis, Lee M.; Delrio, Paolo; Roh, Mark S.; Granchi, Jennifer; Curley, Steven A.

doi:10.1016/s0002-9610(99)00234-2

Cited by 343 publications

(183 citation statements)

References 14 publications

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“…There were no episodes of heat injury to adjacent organs, renal failure, coagulopathy, intrahepatic abscess, symptomatic pleural effusion, or intraoperative bleeding. In contrast, we noted a 2% mortality rate and a 41% clinically significant complication rate in our patients treated with cryoablation [32]. These complications included renal failure requiring dialysis, abscess in the cryoablated tumor, symptomatic pleural effusion, and postoperative coagulopathy.…”

Section: Rfa Compared To Other Local Ablation Techniquesmentioning

confidence: 60%

“…The overall reported complication rates after cryoablation range from 15%-60%, with an average of 45% [31]. We have compared treatment-related serious complications in patients treated with hepatic tumor cryoablation or RFA [32]. Clinically significant RFA treatment-related complications developed in <4% of our patients, and while there were no deaths at the time of that report, we have now had a single RFA-related death (mortality rate 0.3%).…”

Section: Rfa Compared To Other Local Ablation Techniquesmentioning

confidence: 85%

“…This study is also difficult to interpret because cryotherapy alone was used in only 78 patients (33.2%); the majority of patients were treated with cryotherapy plus hepatic artery ligation, transarterial chemoembolization, hepatic artery infusion chemotherapy, or resection of the frozen tumor. Our group has abandoned cryotherapy to treat primary or metastatic liver tumors based on our finding of a significantly higher local tumor recurrence rate with cryoablation compared with RFA (13.6% versus 2.2%, respectively, p < 0.01) and a much higher complication rate following cryoablation (40.7% versus 3.3%, respectively, p < 0.001) [32].…”

Section: Greatest Diametermentioning

confidence: 99%

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Radiofrequency Ablation of Malignant Liver Tumors

2001

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The majority of patients with primary or metastatic hepatic tumors are not candidates for resection because of tumor size, location near major intrahepatic blood vessels precluding a margin-negative resection, multifocality, or inadequate hepatic function related to coexistent cirrhosis. Radiofrequency ablation (RFA) is an evolving technology being used to treat patients with unresectable primary and metastatic hepatic cancers. RFA produces coagulative necrosis of tumor through local tissue heating. Liver tumors are treated percutaneously, laparoscopically, or during laparotomy using ultrasonography to identify tumors and guide placement of the RFA needle electrode. For tumors smaller than 2.0 cm in diameter, one or two deployments of the monopolar multiple array needle electrode are sufficient to produce complete coagulative necrosis of the tumor. However, with increasing size of the tumor, there is a concomitant increase in the number of deployments of the needle electrode and the overall time necessary to produce complete coagulative necrosis of the tumor. In general, RFA is a safe, well-tolerated, effective treatment for unresectable hepatic malignancies less than 6.0 cm in diameter. Effective treatment of larger tumors awaits the development of more powerful, larger array monopolar and bipolar RFA technologies.

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Section: Rfa Compared To Other Local Ablation Techniquesmentioning

confidence: 60%

Section: Rfa Compared To Other Local Ablation Techniquesmentioning

confidence: 85%

Section: Greatest Diametermentioning

confidence: 99%

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Radiofrequency Ablation of Malignant Liver Tumors

2001

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“…A tumour diameter of 30mm or greater and close proximity to major vascular structures are both well documented risk factors for tumour recurrence (6)(7)(8)(9)(10)(11)(12)(13). It is possible that the larger size of one of these tumours may be connected to its recurrence though many larger lesions were successfully treated in this series.…”

Section: A C C E P T E D Article In Pressmentioning

confidence: 85%

Microwave ablation for unresectable hepatic tumours: Clinical results using a novel microwave probe and generator

Bhardwaj

Strickland

Ahmad

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…This is the reason why such a complex therapeutic management of our patient was followed. The most annoying complication of any ablative technique is tumor seeding [27,28], which can be avoided by performing thermocoagulation of the needle tract while removing the needle [1].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Long-Term Survival of a Patient with a Large Unresectable Hepatocellular Carcinoma: Case Report and Review of the Literature~!2010-04-28~!2010-05-29~!2010-07-23~!

Karatzas¹

2010

TOSJ

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Amongst therapies for unresectable hepatocellular carcinomas, radiofrequency ablation (RFA) and hepatic artery chemoembolization have clinical application either for local tumor destruction or to control tumor progression and recurrence rate. Herein we present a patient with a large hepatocellular carcinoma, chronic hepatitis B and congenital absence of left hepatic lobe treated with hepatic artery chemoembolization, multiple RFA sessions and transarterial chemoembolizations resulted in long-term survival far beyond actual expected survival rate, while preserving quality of life.

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Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies

Cited by 343 publications

References 14 publications

Radiofrequency Ablation of Malignant Liver Tumors

Radiofrequency Ablation of Malignant Liver Tumors

Microwave ablation for unresectable hepatic tumours: Clinical results using a novel microwave probe and generator

Long-Term Survival of a Patient with a Large Unresectable Hepatocellular Carcinoma: Case Report and Review of the Literature~!2010-04-28~!2010-05-29~!2010-07-23~!

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