Purpose: To analyse the incidence, risk factors, and outcomes of cataract surgery complicated by a dropped nucleus. Setting: Patients who have received cataract surgery in 18 European countries. Design: Retrospective cross-sectional register-based study. Methods: Data from the European Registry for Quality Outcomes in Cataract and Refractive Surgery (EUREQUO) were analysed. The EUREQUO contains preoperative baseline, intraoperative, and follow-up data. Intraoperative data include dropped nucleus as a complication. Baseline data such as demographic data, ocular comorbidities, surgical difficulties, and visual and refractive outcomes were tested for association with dropped nucleus for the study period 1 January 2008 to 31 December 2018.Results: The number of reported surgeries with complete data was 1,715,348. Dropped nucleus was reported in 1,221 (0.071%) cases during the study period. White cataract, previous vitrectomy, poor preoperative visual acuity, small pupil, pseudoexfoliation, diabetic retinopathy, and male gender were significantly related to dropped nucleus. Year of surgery showed a significant trend of decreasing occurrence of dropped nucleus over time. Eyes with the complication of a dropped nucleus had a poorer visual and refractive outcome also compared with eyes with existing risk factors but no such complication. Conclusion: Many risk factors for dropped nucleus were identified. A significant trend of decreasing occurrence of dropped nucleus was found for the study period. The visual and refractive outcome was poorer for eyes with dropped nucleus.