Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model

Kéramidas, Michelle; Josserand, Véronique; Righini, Christian; Wenk, C.; Faure, Claire; Coll, Jean‐Luc

doi:10.1002/bjs.6986

Cited by 60 publications

(45 citation statements)

References 20 publications

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“…Hybrid PET-CT can guide the surgeon to the lymph node basin that contains the SLN. Fluorescence imaging cameras such as the Fluobeam 38 can guide the surgical exposure and visual identification of the SLN. 39 This can be performed with wide-bandwidth cameras and laparoscopic cameras during robotic-assisted surgery.…”

Section: Discussionmentioning

confidence: 99%

Optimization via specific fluorescence brightness of a receptor-targeted probe for optical imaging and positron emission tomography of sentinel lymph nodes

et al. 2013

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Abstract. The optical properties of a receptor-targeted probe designed for dual-modality mapping of the sentinel lymph node (SLN) was optimized. Specific fluorescence brightness was used as the design criterion, which was defined as the fluorescence brightness per mole of the contrast agent. Adjusting the molar ratio of the coupling reactants, IRDye 800CW-NHS-ester and tilmanocept, enabled us to control the number of fluorescent molecules attached to each tilmanocept, which was quantified by 1 H nuclear magnetic resonance spectroscopy. Quantum yields and molar absorptivities were measured for unconjugated IRDye 800CW and IRDye 800CW-tilmanocept (800CW-tilmanocept) preparations at 0.7, 1.5, 2.3, 2.9, and 3.8 dyes per tilmanocept. Specific fluorescence brightness was calculated by multiplication of the quantum yield by the molar absorptivity and the number of dyes per tilmanocept. It predicted that the preparation with 2.3 dyes per tilmanocept would exhibit the brightest signal, which was confirmed by fluorescence intensity measurements using three optical imaging systems. When radiolabeled with 68 Ga and injected into the footpads of mice, the probe identified SLNs by both fluorescence and positron emission tomography (PET) while maintaining high percent extraction by the SLN. These studies demonstrated the feasibility of 800CW-tilmanocept for multimodal SLN mapping via fluorescence and PET-computed tomography imaging. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 99%

Optimization via specific fluorescence brightness of a receptor-targeted probe for optical imaging and positron emission tomography of sentinel lymph nodes

et al. 2013

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“…A peptide like scaffold molecule RAFT-c-(-RGDfK-) 4 has shown to target avb3 integrin in vivo and in vitro [66][67][68][69][70]. This peptide has been conjugated to multiple fluorophores or coupled with quantum dots to visualize avb3 integrin positive head and neck squamous cell carcinoma [75][76][77][78][79]. Transferrin receptor (TfR) is also appreciated to overexpress in the head and neck cancer and often associated with poor prognosis [80].…”

Section: Head and Neck Image Guided Surgerymentioning

confidence: 98%

Image guided surgery in the management of head and neck cancer

Iqbal

Pan

2016

Oral Oncology

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“…Appropriate processing nonetheless makes it possible to reconstruct an image of the fluorophore concentration with sufficient precision, thereby enabling visualization, for example, of an ovarian tumor induced in a mouse. This processing can thus guide the surgeon toward the target [17]. Another interesting example might be detection of the surgical margins during a radical prostatectomy.…”

Section: Improvement In Perceptionmentioning

confidence: 99%

How today's robots work and perspectives for the future

Cinquin

2011

Journal of Visceral Surgery

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In standard practice, the surgeon perceives multiple types of data (visual, tactile, auditory, even olfactory information), decides at each moment the optimal strategy to pursue, and acts in accordance with this strategy. Here we refer to as a ''surgical robot'' any system able to use digital data to help the surgeon work physically on the patient. Every surgical robot therefore uses sensors, its own capacity to process the information they collect, and instruments. We will use this common framework to describe and propose a classification of the current robots and to discuss their future prospects.The sources of information used by the robots in clinical practice today are, on the one hand, medical images, both pre-and intraoperative, and on the other hand, images and measurements of position, of three-dimensional (3D) shapes, and of force.Historically, beginning in 1988, X-ray CT was the first imaging method used to plan robotic stereotactic neurosurgery procedures [1], which were then performed in the CT scanner room. The superior performance of magnetic resonance imaging (MRI) for brain imaging, as well as the fact that an operating room is much better adapted to surgery than the scanner room, led us to suggest that stereotactic neurosurgical procedures should be guided by a robot that can use intraoperative MRI [2] and radiography (Fig. 1). Ultrasound subsequently appeared to be a very useful source of images for guiding surgery, including procedures involving bones [3]. These sources of images have since been widely used by surgical robots.Other sensors, initially developed for computer vision applications, now play an important role in these robots. Three-dimensional position sensors or trackers (also called 3D localizers), for example, are an essential component of all the surgical navigation systems presented in Section Action: classification of surgical robots. Their principle is to make

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Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model

Abstract: NIR image-guided surgery improved the quality of surgery for peritoneal carcinomatosis by doubling the number of nodules detected and significantly reducing the duration of surgery.

Cited by 60 publications

References 20 publications

Optimization via specific fluorescence brightness of a receptor-targeted probe for optical imaging and positron emission tomography of sentinel lymph nodes

Optimization via specific fluorescence brightness of a receptor-targeted probe for optical imaging and positron emission tomography of sentinel lymph nodes

Image guided surgery in the management of head and neck cancer

How today's robots work and perspectives for the future

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