Intraoperative Monitoring Cerebral Blood Flow During the Treatment of Brain Arteriovenous Malformations in Hybrid Operating Room by Laser Speckle Contrast Imaging

Tao, Sicai; Zhang, Tingbao; Zhou, Kai; Liu, Xiaohu; Feng, Yu; Zhao, Wenyuan; Chen, Jincao

doi:10.3389/fsurg.2022.855397

Cited by 9 publications

(8 citation statements)

References 42 publications

(70 reference statements)

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“…A whole‐brain scan was performed by using LSCI. The random speckle pattern, which is exploited by laser speckle contrast analysis, can be generated by irradiating the tissue with laser light and varies as blood cells move in the selected area 20 . The LSCI system quantified regional tissue blood flow within the ischemic area.…”

Section: Methodsmentioning

confidence: 99%

“…The random speckle pattern, which is exploited by laser speckle contrast analysis, can be generated by irradiating the tissue with laser light and varies as blood cells move in the selected area. 20 The LSCI system quantified regional tissue blood flow within the ischemic area. The degree of perfusion was represented on a spectrum from blue (low perfusion) to red (high perfusion).…”

Section: Cbf By Laser Speckle Contrast Image (Lsci)mentioning

confidence: 99%

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The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke

Zhang,

Peng,

Zhang

et al. 2023

Journal of Pineal Research

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Stroke is the leading cause of death and disability worldwide. Novel and effective therapies for ischemic stroke are urgently needed. Here, we report that melatonin receptor 1A (MT1) agonist ramelteon is a neuroprotective drug candidate as demonstrated by comprehensive experimental models of ischemic stroke, including a middle cerebral artery occlusion (MCAO) mouse model of cerebral ischemia in vivo, organotypic hippocampal slice cultures ex vivo, and cultured neurons in vitro; the neuroprotective effects of ramelteon are diminished in MT1‐knockout (KO) mice and MT1‐KO cultured neurons. For the first time, we report that the MT1 receptor is significantly depleted in the brain of MCAO mice, and ramelteon treatment significantly recovers the brain MT1 losses in MCAO mice, which is further explained by the Connectivity Map L1000 bioinformatic analysis that shows gene‐expression signatures of MCAO mice are negatively connected to melatonin receptor agonist like Ramelteon. We demonstrate that ramelteon improves the cerebral blood flow signals in ischemic stroke that is potentially mediated, at least, partly by mechanisms of activating endothelial nitric oxide synthase. Our results also show that the neuroprotection of ramelteon counteracts reactive oxygen species‐induced oxidative stress and activates the nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 pathway. Ramelteon inhibits the mitochondrial and autophagic death pathways in MCAO mice and cultured neurons, consistent with gene set enrichment analysis from a bioinformatics perspective angle. Our data suggest that Ramelteon is a potential neuroprotective drug candidate, and MT1 is the neuroprotective target for ischemic stroke, which provides new insights into stroke therapy. MT1‐KO mice and cultured neurons may provide animal and cellular models of accelerated ischemic damage and neuronal cell death.

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Section: Methodsmentioning

confidence: 99%

Section: Cbf By Laser Speckle Contrast Image (Lsci)mentioning

confidence: 99%

The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke

Zhang,

Peng,

Zhang

et al. 2023

Journal of Pineal Research

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“…[192] Miller et al used LSCI for CBF assessment during cerebral aneurysm surgery and arteriovenous malformation resection in humans. [193] Tao et al applied LSCI for CBF control during arteriovenous malformation resection, [194] demonstrating that LSCI is highly effective for real-time detection of pathological hyperperfusion at decent spatial-temporal resolution. Guo et al proposed random matrix-based LSCI for intraoperative laparoscopic surgery.…”

Section: Brain Vasculature Assessmentmentioning

confidence: 99%

“…[ 193 ] Tao et al. applied LSCI for CBF control during arteriovenous malformation resection, [ 194 ] demonstrating that LSCI is highly effective for real‐time detection of pathological hyperperfusion at decent spatial‐temporal resolution. Guo et al.…”

Section: Recent Progress In Dls‐based Imaging Of Blood Flowmentioning

confidence: 99%

Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

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Dynamic light scattering (DLS) is a well known experimental approach uniquely suited for the characterization of small particles undergoing Brownian motion in randomly inhomogeneous turbid scattering medium, including water suspension, polymers in solutions, cells cultures, and so on. DLS is based on the illuminating of turbid medium with a coherent laser light and further analyzes the intensity fluctuations caused by the motion of the scattering particles. The DLS‐based spin‐off derivative techniques, such laser Doppler flowmetry (LDF), diffusing wave spectroscopy (DWS), laser speckle contrast imaging (LSCI), and Doppler optical coherence tomography (DOCT), are exploited widely for non‐invasive imaging of blood flow in brain, skin, muscles, and other biological tissues. The recent advancements in the DLS‐based imaging technologies in frame of their application for brain blood flow monitoring, skin perfusion measurements, and non‐invasive blood micro‐circulation characterization are overviewed. The fundamentals, breakthrough potential, and practical findings revealed by DLS‐based blood flow imaging studies, including the limitations and challenges of the approach such as movement artifacts, non‐ergodicity, and overcoming high scattering properties of studied medium, are also discussed. It is concluded that continued research and further technological advancements in DLS‐based imaging will pave the way for new exciting developments and insights into blood flow diagnostic imaging.

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“…LSCI allows clinicians to locate areas of poor perfusion or to observe hyperperfusion in quasi real time due to the relatively low computational burden of converting image data into perfusion maps. 2 …”

Section: Introductionmentioning

confidence: 99%

In vivo laser speckle contrast imaging of microvascular blood perfusion using a chip-on-tip camera

Markwalder,

Gush,

Khan

et al. 2024

iScience

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Intraoperative Monitoring Cerebral Blood Flow During the Treatment of Brain Arteriovenous Malformations in Hybrid Operating Room by Laser Speckle Contrast Imaging

Cited by 9 publications

References 42 publications

The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke

The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke

Advances in Dynamic Light Scattering Imaging of Blood Flow

In vivo laser speckle contrast imaging of microvascular blood perfusion using a chip-on-tip camera

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