Intraoperative microelectrode and semi-microelectrode recording during the physiological localization of the thalamic nucleus ventral intermediate

Garonzik, Ira M.; Hua, Sherwin E.; Ohara, Shuichi; Lenz, Frederick A.

doi:10.1002/mds.10155

Cited by 72 publications

(50 citation statements)

References 48 publications

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“…1), but the thalamic nuclei are not visible on standard MRI machines and identifying the target in the thalamus requires indirect targeting using atlas coordinates. In surgery, microrecordings are used in many centers to localize neuronal activity typical of a nucleus, 14,15 although the safety of this process has been questioned. 16 Local field potentials have also been suggested to help in the identification of the STN, although their role is not fully established.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Deep Brain Stimulation for Parkinson’s Disease

2008

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Summary:The surgical treatment of Parkinson's disease has been through a revival phase over the last 20 years with the development of deep brain stimulation (DBS). Thalamic DBS was developed first and has proven to be a very effective treatment for tremor. The limitation is the lack of effect on other symptoms. Other targets were therefore investigated, and the procedure was applied to the subthalamic nucleus (STN) and the internal globus pallidus (GPi). STN stimulation can improve a wide range of symptoms and is currently the preferred target for many patients. Nevertheless, the morbidity seems higher than with other targets, and the selection criteria have to be quite strict. When STN DBS is not advised, thalamic DBS remains an option for patients with severe tremor, and GPi stimulation for those with severe dyskinesias. DBS remains a symptomatic treatment for a limited number of patients; it does not seem to alter the disease progression, and many patients are not suitable. There is, therefore, the need for further research into other targets and other approaches.

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Section: Surgical Proceduresmentioning

confidence: 99%

Deep Brain Stimulation for Parkinson’s Disease

2008

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“…High-frequency electrical stimulation of axonal pathways in the CNS has been used chronically to treat neurological and psychiatric disorders (Mayberg et al 2005;Nuttin et al 2003) and adopted as a neurophysiological tool to map the brain and probe sensorimotor deficits in the operating room (Garonzik et al 2002;Thiebaut de Schotten et al 2005). Although axonal stimulation is thought to elicit repetitive discharges in the pathways stimulated (McIntyre et al 2004), clinically such high-frequency stimulation instead reduces abnormal function, without obvious influence on normal motor or cognitive functions (Mayberg et al 2005;O'Suilleabhain et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Cellular Mechanisms Preventing Sustained Activation of Cortex During Subcortical High-Frequency Stimulation

Iremonger¹,

Anderson²,

Hu³

et al. 2006

Journal of Neurophysiology

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. Kiss. Cellular mechanisms preventing sustained activation of cortex during subcortical high-frequency stimulation. J Neurophysiol 96: 613-621, 2006. First published March 22, 2006 doi:10.1152/jn.00105.2006. Axonal excitation has been proposed as a key mechanism in therapeutic brain stimulation. In this study we examined how high-frequency stimulation (HFS) of subcortical white matter tracts projecting to motor cortex affects downstream postsynaptic responses in cortical neurons. Whole cell recordings were performed in the primary motor cortex (M1) and ventral thalamus of rat brain slices. In M1, neurons showed only an initial depolarization in response to HFS, after which the membrane potential returned to prestimulation levels. The prolonged suppression of excitation during stimulation was neither associated with GABAergic inhibition nor complete action potential failure in stimulated axons. Instead we found that HFS caused a depression of excitatory synaptic currents in postsynaptic neurons that was specific to the stimulated subcortical input. These data are consistent with the hypothesis that axonal HFS produces a functional deafferentation of postsynaptic targets likely from depletion of neurotransmitter.

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“…The overall BG model we have chosen is one of the simplest portrayals of BG circuitry involved in the fundamental aspects of PD [7] . A more detailed model, incorporating more of the cell types found in these nuclei and more of the connections that have been verified by other investigators [8][9][10][11][12][13][48][49][50][51][52][53] ( fig. 2 ), particularly in the cortex and thalamic parts of the model, may be important and will be investigated in future work.…”

Section: Discussionmentioning

confidence: 96%

Modeling Parkinsonian Circuitry and the DBS Electrode

Shils¹,

Mei²,

Arle³

2007

Stereotact Funct Neurosurg

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Treatment with deep brain stimulation (DBS) for Parkinson’s disease (PD) has become routine over the past decade, particularly using the subthalamic nucleus (STN) as a target and utilizing microelectrode recordings to ensure accurate placement of the stimulating electrodes. The clinical changes seen with DBS in the STN for PD are consistently beneficial, but there continues to be only marginal understanding of the mechanisms by which DBS achieves these results. Using an analytical model of the typical DBS 4-contact electrode and software developed to simulate individual neurons and neural circuitry of the basal ganglia we compare the results of the model to those of data obtained during DBS surgery of the STN. Firing rate, interspike intervals and regularity analyses were performed on the simulated data and compared to results in the literature.

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Intraoperative microelectrode and semi-microelectrode recording during the physiological localization of the thalamic nucleus ventral intermediate

Cited by 72 publications

References 48 publications

Deep Brain Stimulation for Parkinson’s Disease

Deep Brain Stimulation for Parkinson’s Disease

Cellular Mechanisms Preventing Sustained Activation of Cortex During Subcortical High-Frequency Stimulation

Modeling Parkinsonian Circuitry and the DBS Electrode

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