Intraoperative Mania During Deep Brain Stimulation for Parkinson Disease

Venkataramaiah, Sudhir; Yadav, Ravi; Srinivas, Dwarakanath; Bhadrinarayan, Varadarajan; Pal, Pramod Kumar

doi:10.1097/ana.0000000000000393

Cited by 2 publications

(1 citation statement)

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“…After the binding of NRG1 with its receptor ErbB4, it could stimulate the downstream signaling pathway and lead to abnormal neuronal discharge, finally leading to the production of mania. [2,3] Thus, reducing the content of the NRG1 or inhibiting the expression of the ErbB4 on the noradrenergic neurons was vital for mania prevention. In our experiment, the objective was to investigate the novel therapeutic options for mania and to reveal its mechanism in the meantime.…”

Section: Introductionmentioning

confidence: 99%

Retracted: A new Co(II)‐coordination polymer: Photocatalytic studies and treatment values on mania by reducing the ErbB4 expression on the noradrenergic neurons

Zhou

Wang

Lin

et al. 2021

J Chinese Chemical Soc

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A novel coordination polymer based on Co(II) has been generated utilizing the 4,4′,4″‐phosphanetriyltribenzoic acid (H3tpp) as the tritopic connector in the existence of a second N‐donor ligand 3,3′‐bipyridine (3,3′‐bpy) under the solvothermal reaction conditions, and its chemical formula is [Co3(tpp)2(3,3′‐bpy)]·7DMF (1). Moreover, under ultraviolet irradiation, complex 1 has high photocatalytic activities for methylene blue degradation, and its photodegradation performance does not show much reduction after three cycles of experiments. Furthermore, the compound's biological activity against the mania was assessed, and the protentional mechanism was discussed. First, the neuroregulin1 content in the hippocampus was detected via enzyme‐linked immunosorbent assay to evaluate the compound's treatment activity on mania. Then, the ErbB4 relative expression levels were detected using real‐time reverse transcription‐polymerase chain reaction. The carboxyl groups have been confirmed to be responsible for all the binding interactions formed by molecular docking simulation.

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Section: Introductionmentioning

confidence: 99%