Intraoperative Injection of Coloring Dye in the Surgical Treatment of Hidradenitis Suppurativa: A Case Report

Abstract

Hidradenitis suppurativa (HS) is a recurring and chronic inflammatory skin disease. Various medical and surgical treatments, with varying degrees of efficacy, have been applied based on the Hurley staging system. Since medical treatment cannot change the natural course of the disease and relapse is inevitable in the long-term, radical excision to reduce recurrences is considered as the only curative therapy option for patients with severe II and III stage HS. However, such methods may require intensive reconstructive surgeries and are often accompanied by intraoperative or postoperative problems, resulting in extended treatments. Several methods to detect the degree of the disease and define the resection area have been employed; coloring agents have also been recommended as an option. In this case, we focused on the use of a coloring dye to determine the precise resection margin for a patient with severe HS, as there have been no conclusive reports on the use of a coloring dye in intraoperative operations or follow-up findings. This method could help preserve more viable tissue to reduce the possibility of complications and the duration of hospitalization.

Study of PEG-b-PLA/Eudragit S100 Blends on the Nanoencapsulation of Indigo Carmine Dye and Application in Controlled Release

“…This process was obtained by taking an encapsulation approach to entrap water-soluble substances within the aqueous core of hydrophobic nanocapsules, namely, the water-in-oil-in-water (W 1 /O/W 2 ) double emulsion method . The model dye IC has already been established as a suitable agent in a wide variety of applications including as a diagnostic tool in clinical medicine. − The encapsulating material was based on a solution blend of two biocompatible polymers that could form a negatively charged interior wall. Specifically, the binary blend was composed of poly­(ethylene glycol)- block -poly­( d , l -lactic acid) (PEG- b -PLA with PEG and PDLLA molecular weights of 5 and 100 kDa, respectively) with 10% w/w Eudragit S100 (1:2 copolymer of methacrylic acid and methyl methacrylate).…”