Intraoperative frozen section diagnosis of depth of myometrial invasion in endometrial adenocarcinoma

Accuracy of Frozen Sections for Intraoperative Diagnosis of Complex Atypical Endometrial Hyperplasia

“…The size of specimen, insufficient time for examination, problematic transfer of specimen to the pathology laboratory (like the ambient temperature), the bleeding time of uterus, the presence of atrophic endometrium, the cell type and grade level, the number of sections received and the presence of experienced pathologists are the limitations of FS. Moreover, it is very difficult to evaluate myometrial invasion if the tumor is located at cornual area or adenomyotic lesions (Fanning et al, 1990).…”

Preoperative selection of patients with low-stage endometrial cancer at high risk of pelvic lymph node metastases

“…Nevertheless, because of the costs, logistics problems, and time investment necessary to conduct an MRI, we find TVS to be a much more attractive choice for the preoperative selection of high-risk patients. It is also possible to determine the depth of myometrial infiltration during surgery by means of either macroscopic investigation of the uterus or intraoperative frozen section diagnosis (22)(23)(24)(25) . The most important drawback of these two techniques, however, is that preoperative selection of high-risk patients is not possible, so qualified surgery for pelvic lymphadenectomy as well as surgery time is difficult to plan.…”

Significance of Concurrent Endometrial Cancer in Women With a Preoperative Diagnosis of Atypical Endometrial Hyperplasia

“…[27][28][29][30][31][32][33][34] Routine MRI scanning of all patients with AEH to identify those patients with deep myometrial invasion would have such a low yield that it would not be cost-effective. In our review, only 6% of patients would have benefited from such an approach.…”

“…29,30 Concurrent use of frozen section analysis can further enhance intraoperative risk determination in patients with endometrial cancer. [31][32][33][34] However, in a review of 23 patients, only four of 11 patients found to have concurrent EC were identified by frozen section assessment. 31 The limitations of our study arise from the relatively small number of patients and the retrospective collection of data.…”

“…[31][32][33][34] However, in a review of 23 patients, only four of 11 patients found to have concurrent EC were identified by frozen section assessment. 31 The limitations of our study arise from the relatively small number of patients and the retrospective collection of data. We did not attempt to review the effect of non-surgical treatment of AEH and the subsequent incidence of concurrent EC.…”