Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses

Abstract

Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses.

Intraoperative frozen section analysis of ovarian tumors: a 11-year review of accuracy with clinicopathological correlation in a Hong Kong Regional hospital

“…Apart from a slightly higher prevalence of borderline tumors in our hospital, our series showed a similar distribution to the recent Cochrane systematic review 3. In that systematic review, borderline and malignant tumors were considered test-positive and benign lesions test-negative, the average IFS sensitivity was 96.5% and specificity was 89.5%.…”

“…In the current study, 24.7% of borderline tumors at IFS were upgraded to malignant tumors at final diagnosis. The figure was similar to the reported average upgrade rate of 21% 3. Diagnoses were considered concordant when the IFS diagnosis was borderline or at least borderline with final malignant pathology, as these cases were managed in a similar way intra-operatively 10…”

“…An accurate IFS can provide a reliable guide, thus minimizing the chance of overtreatment with unnecessary procedures or undertreatment requiring a second operation or adjuvant chemotherapy. A recent systematic review has concluded that IFS has an average sensitivity of 90% and specificity of 99.5% in diagnosing ovarian malignancy 3. It is well known that IFS has its limitations, such as in the diagnosis of borderline and mucinous ovarian tumors 4.…”

Intraoperative Frozen Section of Ovarian Tumors: A 6-Year Review of Performance and Potential Pitfalls in an Australian Tertiary Referral Center

“…3 In this series, one third of tumors diagnosed as borderline by IFS were malignant at paraffin section with underdiagnosis strongly associated with older age. Preoperative magnetic resonance imaging (MRI) has been investigated as a test for borderline and malignant ovarian tumors.…”

An Evaluation of Frozen Section and Lymph Node Dissection Results for Mucinous Ovarian Tumors

“…11 Frozen section diagnosis of malignancy has been extensively studied and demonstrates greater than 90% accuracy for ovarian tumors. 12,13 However, accuracy varies among histologic types of ovarian tumors, and up to 34% of mucinous tumors have their malignancy diagnosis reclassified on final pathology. 13Y18 To date, the accuracy of frozen section in diagnosing histologic type of ovarian tumor has not been studied.…”