Intraoperative fluorescence control with chlorin E6 in resection of glial brain tumors

Rynda, A. Yu.; Olyushin, V. E.; Ростовцев, Д. М.; Zabrodskaya, Yu. M.; Tastanbekov, M. M.; Papayan, G. V.

doi:10.17116/neiro20218504120

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…Rynda et al evaluated fluorescence navigation with Ce6, which had proven efficacy in malignant glioma surgery in a comparative morphopathological analysis. Rynda also used this technique in brain glioma surgery, resulting in weak fluorescence in all patients with grade II gliomas and strong fluorescence in almost all patients with grade III–IV gliomas. The sensitivity of Ce6 to fluorescence diagnosis was 72.2% for grade II gliomas, 83.8% for grade III gliomas, and 87.7% for grade IV gliomas.…”

Section: Other Applications Of Ce6mentioning

confidence: 99%

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

et al. 2023

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Chlorin e6 (Ce6) has been extensively researched and developed as an antitumor therapy. Ce6 is a highly effective photosensitizer and sonosensitizer with promising future applications in photodynamic therapy, dynamic acoustic therapy, and combined acoustic and light therapy for tumors. Ce6 is also being studied for other applications in fluorescence navigation, antibacterials, and plant growth regulation. Here we review the role and research status of Ce6 in tumor therapy and the problems and challenges of its clinical application. Other biomedical effects of Ce6 are also briefly discussed. Despite the difficulties in clinical application, Ce6 has significant advantages in photodynamic therapy (PDT)/sonodynamic therapy (SDT) against cancer and offers several possibilities in clinical utility.

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Section: Other Applications Of Ce6mentioning

confidence: 99%

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

et al. 2023

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“…It was shown that the use of 5-ALA helps to achieve a high tumor resection rate and improve patient prognosis [17]. Additionally, in several studies, chlorin e6 (Ce6) and talaporfin sodium were used for FD [18,19].…”

Section: Introductionmentioning

confidence: 99%

The Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in the Functional Motor Area after Ineffective Use of 5-ALA: Preliminary Results

et al. 2022

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The treatment of glial brain tumors is an unresolved problem in neurooncology, and all existing methods (tumor resection, chemotherapy, radiotherapy, radiosurgery, fluorescence diagnostics, photodynamic therapy, etc.) are directed toward increasing progression-free survival for patients. Fluorescence diagnostics and photodynamic therapy are promising methods for achieving gross total resection and additional treatment of residual parts of the tumor. However, sometimes the use of one photosensitizer for photodynamic therapy does not help, and the time until tumor relapse barely increases. This translational case report describes the preliminary results of the first combined use of 5-ALA and chlorin e6 photosensitizers for fluorescence-guided resection and photodynamic therapy of glioblastoma, which allowed us to perform total resection of tumor tissue according to magnetic resonance and computed tomography images, remove additional tissue with increased fluorescence intensity without neurophysiological consequences, and perform additional therapy. Two months after surgery, no recurrent tumor and no contrast uptake in the tumor bed were detected. Additionally, the patient had ischemic changes in the access zone and along the periphery and cystic-glial changes in the left parietal lobe.

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“…Chlorin e6 (Ce6) and its derivatives are promising PSs with high diagnostic and therapeutic efficiency in neuro-oncology [ 20 , 21 , 22 ]. Ce6 is a second-generation PS with high efficacy and minimal dark toxicity [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer

et al. 2022

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Fluorescence diagnostics is one of the promising methods for intraoperative detection of brain tumor boundaries and helps in maximizing the extent of resection. This paper presents the results of a pilot study on the first use of the chlorin e6 photosensitizer and a two-channel video system for fluorescence-guided resection of pituitary adenomas. The study’s clinical part involved two patients diagnosed with hormonally inactive pituitary macroadenomas and one patient with a hormonally active one. All neoplasms had different sizes and growth patterns. The data showed accumulation of chlorin e6 in tumor tissues in high concentrations: Patient 1: 2 mg/kg, Patient 2: 5 mg/kg, and Patient 3: 4 mg/kg. For Patient 1, the residual part of the tumor was not resected since it was intimately attached to the anterior genu of the internal carotid artery. For Patients 2 and 3, no regions of increased Ce6 accumulation were detected in the tumor foci after resection. Therefore, the use of the Ce6 and a two-channel video system helped to achieve a high degree of tumor resection in each case.

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Intraoperative fluorescence control with chlorin E6 in resection of glial brain tumors

Cited by 8 publications

References 15 publications

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

The Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in the Functional Motor Area after Ineffective Use of 5-ALA: Preliminary Results

A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer

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