Intraoperative Findings in Spinal Lesions

Vetrano, Ignazio G.; Prada, Francesco

doi:10.1007/978-3-319-25268-1_6

Cited by 5 publications

(5 citation statements)

References 41 publications

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“…As an intraoperative real-time imaging method ultra sound states the gold standard and is integrated in daily clinical practice. But spatial resolution capabilities also inhibits depiction of the vessel wall composition [ 2 – 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Histology—albeit its’ superior and unexcelled resolution—excludes an in vivo approach and is further constrained by numerous process-related artifacts, such as specimen shrinkage, tissue damage and tissue separation [ 1 ]. Traditional intraoperative imaging modalities such as ultrasound lack the necessary spatial resolution to delineate vessel wall characteristics as well as the possibility of microscope integration [ 2 – 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Extravascular optical coherence tomography of cerebral vessel walls in vivo

et al. 2023

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Purpose Evaluation of extravascular, microscope integrated OCT (iOCT) as an in vivo imaging modality of cerebral blood vessels and as an intraoperative imaging method. Methods Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one incidental cerebral vasospasm (n = 1) in (n = 10) patients. Post procedural analysis of OCT volume scans, microscopic images and videos during the time of scan as well as measurements of the diameter of vessel walls and its layers with an accuracy of 7.5 μm. Results iOCT was feasible during vascular microsurgical procedures. In all scanned arteries a clear delineation of the physiological three layered vessel wall composition could be achieved. Pathological arteriosclerotic alterations of cerebral artery walls could precisely be demonstrated. Major superficial cortical veins conversely presented a mono layered composition. First in vivo measurements of vascular mean diameters were possible. Cerebral artery walls showed a diameter of 296 μm, tunica externa 78 μm, media 134 μm and interna 84 μm. Conclusion For the first time the microstructural composition of cerebral blood vessels could be illustrated in vivo. Due to an outstanding spatial resolution a clear definition of physiological and pathological characteristics was possible. Therefore, microscope integrated optical coherence tomography holds promise for basic research in the field of cerebrovascular arteriosclerotic diseases and for intraoperative guidance during microvascular surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extravascular optical coherence tomography of cerebral vessel walls in vivo

et al. 2023

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“…Ultrasound based methods-based methods are the gold standard for in vivo dynamic sectional imaging of the central nervous system, but lack the spatial resolution to delineate the microstructural composition of the SAS. [2][3][4] Still imaging modalities are needed to display intact tissue and pathological alterations in the context of observational research and as intraoperative imaging tools. The present study reveals that microscope-integrated OCT might be capable of closing this neuroimaging gap.…”

Section: Discussionmentioning

confidence: 99%

“…Conventional imaging tools like magnetic resonance imaging (MRI) and ultrasound (US) - currently the most established tool for dynamic sectional imaging of the brain - are llmited here due to their lack of spatial resolution. 2–4…”

Section: Introductionmentioning

confidence: 99%

“…Conventional imaging tools like magnetic resonance imaging (MRI) and ultrasound (US)currently the most established tool for dynamic sectional imaging of the brain -are llmited here due to their lack of spatial resolution. [2][3][4] In contrast, optical coherence tomography (OCT) shows an exceedingly high maximal spatial resolution of 1-15 µm, which approaches the resolution of conventional histopathology. 5 OCT imaging depends on the detection of back scattered nearinfrared light.…”

Section: Introductionmentioning

confidence: 99%

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First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

Hartmann

Stein

Neyazi

et al. 2019

Ther Adv Neurol Disord

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The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients ( n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a mean depth of 570 µm frontotemporal. The ABCM showed a mean depth of 74 µm frontotemporal. These results indicate that OCT provides a dynamic, non-invasive tool for real-time imaging of the SAS and adjacent anatomical structures at micrometer spatial resolution. Further studies are necessary to evaluate the value of OCT during microsurgical procedures.

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