Intraoperative extracorporeal irradiation for giant sarcoma-infiltrated calvarium: a case report

Oshima, Akito; Yoshida, Daisaku; Hiruma, Toru; Washimi, Kota; Okubo, Yoichiro; Sato, Hidemitsu

doi:10.1080/02688697.2021.1888875

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Another single case of EITC has reported good outcomes 29 months following surgery for an anterior skull base meningioma with frontal bone extension [ 13 ]. In addition to meningioma, EITC has been successful in a case of calvarial sarcoma [ 25 ], supporting its use in a range of bone-invasive neoplasms affecting the calvarium.…”

Section: Discussionmentioning

confidence: 99%

Intra-operative extracorporeal irradiation of tumour-invaded craniotomy bone flap in meningioma: a case series

Cook,

Burton,

Jefferies

et al. 2024

Acta Neurochir

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Background Extracorporeal irradiation of tumorous calvaria (EITC) can be performed to restore function and form of the skull after resection of bone-invasive meningioma. We sought to examine the rate of tumour recurrence and other selected outcomes in patients undergoing meningioma resection and EITC. Methods Retrospective single-centre study of adult patients undergoing meningioma resection and EITC between January 2015 and November 2022 at a tertiary neurosurgical centre. Patient demographics, surgery data, tumour data, use of adjuvant therapy, surgical complications, and tumour recurrences were collected. Results Eighteen patients with 11 (61%) CNS WHO grade 1, 6 (33%) grade 2, and 1 (6%) grade 3 meningiomas were included. Median follow-up was 42 months (range 3–88). Five (28%) patients had a recurrence, but none were associated with the bone flap. Two (11%) wound infections requiring explant surgery occurred. Six (33%) patients required a further operation. Two operations were for recurrences, one was for infection, one was a washout and wound exploration but no evidence of infection was found, one patient requested the removal of a small titanium implant, and one patient required a ventriculoperitoneal shunt for a persistent CSF collection. There were no cases of bone flap resorption and cosmetic outcome was not routinely recorded. Conclusion EITC is feasible and fast to perform with good outcomes and cost-effectiveness compared to other reconstructive methods. We observed similar recurrence rates and lower infection rates requiring explant compared to the largest series of cranioplasty in meningioma. Cosmetic outcome is universally under-reported and should be reported in future studies.

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Section: Discussionmentioning

confidence: 99%