Intraoperative Electron Beam Radiotherapy during Radical Surgery for Locally Advanced and Recurrent Cervical Cancer

Perioperative high-dose-rate brachytherapy in locally advanced and recurrent gynecologic cancer: Initial results of a phase II trial

“…Although the followup is still short, the current results compare well with historical data from our institution using IOERT in gynecologic cancer (13,18). The University of Navarra (13) reported on 26 patients with miscellaneous recurrent gynecologic cancer treated with 10e25 Gy of IOERT between 1985 and 1992.…”

“…The 4-year local control rates for previously irradiated and unirradiated patients were 33% and 77%, respectively. An updated report of that series (18) included 36 patients with locally recurrent cervical cancer treated with IOERT alone (n 5 31) or combined with preoperative EBRT (n 5 5). The 10-year local control rate was 46.4% for the whole series, but this decreased to 39.2% for the patients treated with IOERT alone.…”

Intraoperative radiation therapy

“…The University of Navarre in Pamplona has evaluated the incorporation of preoperative chemo radiation, surgery, and IOERT in the treatment of locally advanced primary cervical cancers [51]. From 1988 to 1997, 40 patients (stages IB 2 -IVA) were treated with preoperative chemo-radiation (45 Gy plus Cisplatin 20 mg/m 2 at weeks 1 and 5, with 5-FU 1500 mg days 1-4 and 22-25), followed by surgical resection in 4-6 weeks including an IORT boost (10-15 Gy) to the parametrial resection margins and iliac nodal regions.…”

The usefulness of reirradiation in the treatment of pelvic recurrence of rectal and gynaecological tumours

“…Martínez-Monge et al 14 from Clinica Universitaria of Navarra in 2001 reported their results for locally advanced and recurrent cervical cancer. 67 patients were treated with IOERT.…”