Intraoperative dissemination during gastrectomy for gastric cancer associated with serosal invasion

Tokumitsu, Yukio; Yoshino, Shigefumi; Iida, Michihisa; Yoshimura, Kiyoshi; Ueno, Takayoshi; Hazama, Shoichi; Oka, M.

doi:10.1007/s00595-014-1005-2

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…The detachment of cancer cells from the serosa of primary tumor followed by their attachment to peritoneal mesothelial cells is thought to be crucially important processes for metastasis formation. Meanwhile, recent studies have shown that cancer cell spillage occurs during surgery due to tumor manipulation or lymph node dissection, and such viable cancer cells can also be sources of peritoneal metastasis [ 4 – 9 ]. Therefore, effective intraoperative peritoneal lavage is important to prevent peritoneal recurrence of GC because it can directly remove and/or kill these viable cancer cells before their implantation on the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

“…Free cancer cells spilled into the peritoneal cavity due to tumor manipulation and lymph node dissection during surgery can be a source of peritoneal metastasis [ 4 – 9 ]. Thus, intraoperative peritoneal lavage plays an important role to reduce the risk of peritoneal recurrence because it can directly remove and kill such viable cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer

et al. 2017

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BackgroundPeritoneal lavage with distilled water has been used for surgeries of various cancers to reduce peritoneal recurrence. This study examined whether blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer (GC).ResultsA potassium channel blocker inhibited the occurrence of regulatory volume decrease (RVD) induced by mild hypotonic stimulation, and significantly enhanced cytocidal effects on GC cells. Incubating MKN45 cells with hypotonic solutions containing a potassium channel blocker significantly reduced the formation of peritoneal metastases in nude mice.MethodsThe three human GC cell lines (HGC-27, Kato III, and MKN45) were exposed to mild hypotonic solutions, and the effects of blockade of potassium ion transports during hypotonic stimulation on cell volume changes and cell viabilities were examined. In the in vivo study, MKN45 cells stimulated with mild hypotonic solutions were intraperitoneally injected into nude mice, and the effects of blockade of potassium ion transports during hypotonic stimulation on the formation of peritoneal metastases were evaluated.ConclusionsBlockade of potassium ion transports enhances hypotonicity-induced cytocidal effects on GC cells, which may contribute to development of a novel lavage method for further reduction of peritoneal recurrence in GC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer

et al. 2017

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“…With the progression of gastrointestinal and gynecological tumors, cancer cells exfoliate from the serosal surface and scatter into the peritoneal cavity as IFCCs, which are a major cause of peritoneal recurrence [14] . Also, division of blood vessels and resection of lymph nodes during the surgery could make cancer cells spill into peritoneal cavity to form IFCCs [15] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Hyperthermic Intraperitoneal Chemotherapy to Eradicate Intraperitoneal Free Cancer Cells

Sun

et al. 2016

Translational Oncology

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OBJECTIVE: To assess the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) to eradicate intraperitoneal free cancer cells and to explore the feasibility of cytological cure for peritoneal carcinomatosis (PC). METHODS: The peritoneal lavage fluid (or ascites) from 50 PC patients was collected before and after intraoperative HIPEC, respectively, for conventional cytology test, and conventional and real-time quantitative reverse transcript polymerase chain reaction detecting carcinoembryonic antigen (CEA) mRNA and cytokeratin-20 (CK20) mRNA. The blood samples 3 days before and 7 days after intraoperative HIPEC were also collected for detecting the serum tumor markers, including CEA, carbohydrate antigen (CA) 125, and CA19-9. RESULTS: The positive rate of conventional cytology test before HIPEC versus after HIPEC was100.0% versus 22.0% (P = .000). The positive rates of CEA mRNA and CK20 mRNA before HIPEC versus after HIPEC were 100.0% versus 86.0% (P = .012) and 100.0% versus 96.0% (P = .495), respectively. Moreover, after HIPEC, 18 (36.0%) patients had a decline in CEA mRNA (P = .000), and 17 (34.0%) patients had a decline in CK20 mRNA (P = .000). The positive rates of serum CEA, CA125, and CA199 before HIPEC versus after HIPEC were 52.0% versus 28.0% (P = .014), 52.0% versus 44.0% (P = .423), and 40.0% versus 28.0% (P = .205), respectively. CONCLUSION: HIPEC could effectively eradicate intraperitoneal free cancer cells and partially achieve cytological cure for PC.

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“…OPTC can be detected by conventional cytology and immunocytochemical staining of various tumor markers. 6 A few studies have suggested that surgery itself induces the spread of tumor cells into the peritoneal cavity in patients with gastric cancer 7,8 and colorectal cancer. 9,10 During open pancreatic resection, the tumor is regularly manipulated and potentially even compressed by hand during dissection along the superior mesenteric artery, although this differs depending on the surgical technique applied.…”

Section: Introductionmentioning

confidence: 99%

Tumor manipulation during pancreatic resection for pancreatic cancer induces dissemination of tumor cells into the peritoneal cavity: a systematic review

Steen

Duijvenbode

Dijk

et al. 2018

HPB

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Intraoperative dissemination during gastrectomy for gastric cancer associated with serosal invasion

Abstract: We demonstrated that the intraoperative dissemination of gastric cancer can occur during gastrectomy.

Cited by 11 publications

References 23 publications

Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer

Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer

Assessment of Hyperthermic Intraperitoneal Chemotherapy to Eradicate Intraperitoneal Free Cancer Cells

Tumor manipulation during pancreatic resection for pancreatic cancer induces dissemination of tumor cells into the peritoneal cavity: a systematic review

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