Intraoperative bile duct visualization using near-infrared hyperspectral video imaging

Zuzak, Karel J.; Naik, S.C.; Alexandrakis, George; Hawkins, Darnell F.; Behbehani, Khosrow; Livingston, Edward H.

doi:10.1016/j.amjsurg.2007.05.044

Cited by 72 publications

(65 citation statements)

References 33 publications

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“…If FOV illumination can be made flat, then the primary concern that remains is that the intraoperative tissues are optically heterogeneous. 33 These heterogeneities could mask a faint shadow created by a vessel in reflectance or transmission geometry and thus limit the maximum depth at which a vessel is detectable, as indicated by the adipose tissue phantom reflectance measurements performed in this work ͓Figs. 8͑a͒ and 8͑b͔͒.…”

Section: Discussionmentioning

confidence: 96%

Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth

et al. 2010

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Abstract. Surgeons often cannot see major vessels embedded in adipose tissue and inadvertently injure them. One such example occurs during surgical removal of the gallbladder, where injury of the nearby common bile duct leads to life-threatening complications. Nearinfrared imaging of the intraoperative field may help surgeons localize such critical tissue-embedded vessels. We have investigated how continuous-wave ͑CW͒ imaging performs relative to time-gated widefield imaging, presently a rather costly technology, under broad Gaussian beam-illumination conditions. We have studied the simplified case of an isolated cylinder having bile-duct optical properties, embedded at different depths within a 2-cm slab of adipose tissue. Monte Carlo simulations were preformed for both reflectance and transillumination geometries. The relative performance of CW versus time-gated imaging was compared in terms of spatial resolution and contrast-to-background ratio in the resulting simulated images. It was found that time-gated imaging offers superior spatial resolution and vessel-detection sensitivity in most cases, though CW transillumination measurements may also offer satisfactory performance for this tissue geometry at lower cost. Experiments were performed in reflectance geometry to validate simulation results, and potential challenges in the translation of this technology to the clinic are discussed.

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Section: Discussionmentioning

confidence: 96%

Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth

et al. 2010

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“…Diagnostically, hyperspectral imaging has demonstrated utility for identifying gastric cancer [28] , and in dermatology, for evaluating skin lesions [29] . Furthermore, studies in swine show that hyperspectral imaging devices have the potential to become a real-time intraoperative tool for identifying anatomical structures in minimally non-invasive surgeries, such as laparoscopic cholecystectomy, reducing the need for radioactive contrast and aiding surgeons to avoid adverse and serious injury to non-target, vital tissues [30,31] .…”

Section: Discussionmentioning

confidence: 99%

Hyperspectral imaging of retinal microvascular anatomy

Kashani

Wong

Koulisis

et al. 2015

JBEI

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Background: Hyperspectral image processing has been applied to many aspects of astronomical and earth science research. Furthermore, advances in computed tomographic imaging spectroscopy and diffraction grating design have allowed biological applications for non-invasive tissue analysis. Herein, we describe a hyperspectral computed tomographic imaging spectroscope (HCTIS) that provides high spatial, spectral and temporal resolution ideal for imaging biological tissue in vivo. Methods:We demonstrate proof-of-principle application of the HCTIS by imaging and mapping the microvascular anatomy of the retina of a model organism (rabbit) in vivo. The imaging procedure allows rapid and dense spectral sampling, is non-toxic, non-invasive, and easily adaptable to a commercially available fundus camera system.Results: HCTIS provides highly co-registered temporal, spatial and spectral data with resolution capable of reconstructing the fine vascular tree of the rabbit retina in vivo. Conclusions:We show that HCTIS allows for reliable and reproducible tissue classification and detection using signature discriminant analysis. Future applications of this system may provide promising diagnostic methods for diseases of many tissues.

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“…4,35,38,42,55 There are 3 optical spectroscopy types that are used frequently in biomedicine to monitor light-tissue interaction and therefore to perform in vivo tissue characterization: diffuse reflectance spectroscopy, 6,7,9,12,13,19,20,25,30,34,39,48,50,54,[56][57][58] fluorescence spectroscopy, 26,27 and Raman spectroscopy. 2,11,15,16,31,33 Each of these spectroscopy types targets a particular type of light-tissue interaction and a subset of biological molecules (Fig.…”

Section: Optical Spectroscopymentioning

confidence: 99%

The role of optical spectroscopy in epilepsy surgery in children

Bhatia

Ragheb

Johnson

et al. 2008

FOC

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Object Surgery is an important therapeutic modality for pediatric patients with intractable epilepsy. However, existing imaging and diagnostic technologies such as MR imaging and electrocochleography (ECoG) do not always effectively delineate the true resection margin of an epileptic cortical lesion because of limitations in their sensitivity. Optical spectroscopic techniques such as fluorescence and diffuse reflectance spectroscopy provide a nondestructive means of gauging the physiological features of the brain in vivo, including hemodynamics and metabolism. In this study, the authors investigate the feasibility of using combined fluorescence and diffuse reflectance spectroscopy to assist epilepsy surgery in children. Methods In vivo static fluorescence and diffuse reflectance spectra were acquired from the brain in children undergoing epilepsy surgery. Spectral measurements were obtained using a portable spectroscopic system in conjunction with a fiber optic probe. The optical investigations were conducted at the normal and abnormal cortex as defined by intraoperative ECoG and preoperative imaging studies. Biopsy samples were taken from the investigated sites located within the zone of resection. The optical spectra were classified into multiple subsets in accordance with the ECoG and histological study results. The authors used statistical comparisons between 2 given data subsets to identify unique spectral features. Empirical discrimination algorithms were developed using the identified spectral features to determine if the objective of the study was achieved. Results Fifteen pediatric patients were enrolled in this pilot study. Elevated diffuse reflectance signals between 500 and 600 nm and/or between 650 and 850 nm were observed commonly in the investigated sites with abnormal ECoG and/or histological features in 10 patients. The appearance of a fluorescent peak at 400 nm was observed in both normal and abnormal cortex of 5 patients. These spectral alterations were attributed to changes in morphological and/or biochemical characteristics of the epileptic cortex. The sensitivities and specificities of the empirical discrimination algorithms, which were constructed using the identified spectral features, were all > 90%. Conclusions The results of this study demonstrate the feasibility of using static fluorescence and diffuse reflectance spectroscopy to differentiate normal from abnormal cortex on the basis of intraoperative assessment of ECoG and histological features. It is therefore possible to use fluorescence and diffuse reflectance spectroscopy as an aid in epilepsy surgery.

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Intraoperative bile duct visualization using near-infrared hyperspectral video imaging

Cited by 72 publications

References 33 publications

Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth

Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth

Hyperspectral imaging of retinal microvascular anatomy

The role of optical spectroscopy in epilepsy surgery in children

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