Intraoperative and Postoperative Analgesic Efficacy and Adverse Effects of Intrathecal Opioids in Patients Undergoing Cesarean Section with Spinal Anesthesia

Dahl, Jørgen B.; Jeppesen, Inge S.; Jørgensen, Henrik; Wetterslev, Jørn; Møiniche, S.

doi:10.1097/00000542-199912000-00045

Cited by 319 publications

(119 citation statements)

References 24 publications

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“…11 It is therefore standard practice to use spinal anaesthesia wherever possible. Patient undergoing caesarean section under spinal anaesthesia may get benefit from the coadministration of local anaesthetic and different adjuvants 12 .…”

Section: Discussionmentioning

confidence: 99%

Subarachnoid clonidine or fentanyl with low dose hyperbaric bupivacaine for elective caesarean section - A comparative study

Islam

Ali²,

Begum

et al. 2012

J. Dhaka Natl. Med. Coll. Hosp.

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Section: Discussionmentioning

confidence: 99%

Subarachnoid clonidine or fentanyl with low dose hyperbaric bupivacaine for elective caesarean section - A comparative study

Islam

Ali²,

Begum

et al. 2012

J. Dhaka Natl. Med. Coll. Hosp.

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“…A dose as low as 0.1 mg of intrathecal morphine gives excellent analgesia with minimal or no side effects and that subcutaneous morphine is associated with marked depression of the ventilatory variables. 20 Hence the doses selected for intrathecal administration were 0.1 mg of morphine, since it is the lowest recommended dose for intrathecal administration, 21 and 0.03 mg of buprenorphine keeping in mind the above dose ratios.…”

Section: Selection Of Donementioning

confidence: 99%

A Comparative Study Between Intrathecal Morphine and Intrathecal Buprenorphine for Post - Operative Analgesia Following Caesarian Section Under Sub Arachnoid Block

Varkey¹

2015

jemds

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BACKGROUND: Good pain relief following caesarian section is of great importance and intrathecal opioids provide good quality postoperative analgesia for longer duration. So the following study describes a comparative study between intrathecal morphine and intrathecal buprenorphine for postoperative pain relief following caesarian section (CS) under subarachnoid blockade. AIMS:The study was conducted to compare intrathecal morphine and buprenorphine for post of analgesia following CS, to achieve analgesia without sedation for better maternal child bondage and to popularize intrathecal opioids. MATERIALS AND METHODS: 60 patients posted for CS under SAB were randomly allocated into group A and group B of 30 each, the group A received morphine 0.1 mg and buprenorphine 0.03 mg was given for group B patients along with the local anaesthetic. Subjective assessment of post-operative analgesia was done by direct questioning of the patient and by a five point pain scores. Duration of analgesia was taken as the time interval between the time of injection of intrathecal opiate and the time at which the patient felt pain and requested for additional analgesics. Data's were analyzed using SPSS 16th version. OBSERVATION AND RESULTS: The mean duration of post-operative analgesia with intrathecal morphine was 24.19+4.8 hours and that with buprenorphine was only 11.7+3.28 hours. Over weight patients reported a lower mean duration of analgesia. None of the patients in the study showed any bradycardia, hypotension, desaturation or respiratory depression. Intrathecal opiates decreased the parenteral opiate requirements. The main side effects noticed were nausea in about 43% of patients in morphine group and 33% of patients in buprenorphine group. CONCLUSIONS: Intrathecal morphine 0.1 mg gives good post-operative analgesia of longer duration than buprenorphine 0.03mg. The quality of analgesia provided by intrathecal morphine was superior to intrathecal buprenorphine. There was no incidence of respiratory depression or sedation.

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“…6 In 1990s, analgesic efficacy of intrathecal midazolam in humans has been demonstrated. [7][8][9] Naltrindole, a δ-selective opioid antagonistic agent, suppresses the antinociceptive effect of intrathecal midazolam, suggesting that intrathecal midazolam is involved in the release of an endogenous opioid acting at spinal δ receptors. 10 Benzodiazepines commonly used in the perioperative period include diazepam, midazolam, and lorazepam, as well as the selective benzodiazepine antagonist flumazenil.…”

Section: Introductionmentioning

confidence: 99%

Observation on analgesic efficacy and adverse effects of intrathecal administration of bupivacaine versus bupivacaine-midazolam combination in lower limb surgeries in a tertiary care hospital

Mohsin¹

2016

Int J Res Med Sci

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Intraoperative and Postoperative Analgesic Efficacy and Adverse Effects of Intrathecal Opioids in Patients Undergoing Cesarean Section with Spinal Anesthesia

Cited by 319 publications

References 24 publications

Subarachnoid clonidine or fentanyl with low dose hyperbaric bupivacaine for elective caesarean section - A comparative study

Subarachnoid clonidine or fentanyl with low dose hyperbaric bupivacaine for elective caesarean section - A comparative study

A Comparative Study Between Intrathecal Morphine and Intrathecal Buprenorphine for Post - Operative Analgesia Following Caesarian Section Under Sub Arachnoid Block

Observation on analgesic efficacy and adverse effects of intrathecal administration of bupivacaine versus bupivacaine-midazolam combination in lower limb surgeries in a tertiary care hospital

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