Intraoperative and External Preoperative Radiotherapy in Invasive Bladder Cancer

Calvo, Felipe A.; Aristu, Javier; Abuchaibe, Oscar; Rebollo, Joseba; Hidalgo, O. Fernández; Zudaire, J.J.; Berián, J.M.; Azinovic, I.

doi:10.1097/00000421-199302000-00016

Cited by 17 publications

(6 citation statements)

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“…Single-institution experiences have suggested the usefulness of IORT for primary T4 and recurrent rectal cancer, [10][11][12][13] retroperitoneal sarcoma, 14,15 pancreatic cancer, [16][17][18] and selected recurrent gynecologic [19][20][21] and genitourinary malignancies. [22][23][24][25] Because of the difficulty in accruing large numbers of patients for these disease sites, it is unlikely that phase III studies evaluating the utility of IORT as a definitive therapeutic modality could be performed unless this were done on an international basis. The exception could be in the area of breast cancer, where significant numbers of patients have already been treated in Europe.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative radiation therapy using mobile electron linear accelerators: Report of AAPM Radiation Therapy Committee Task Group No. 72

et al. 2006

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Intraoperative radiation therapy (IORT) has been customarily performed either in a shielded operating suite located in the operating room (OR) or in a shielded treatment room located within the Department of Radiation Oncology. In both cases, this cancer treatment modality uses stationary linear accelerators. With the development of new technology, mobile linear accelerators have recently become available for IORT. Mobility offers flexibility in treatment location and is leading to a renewed interest in IORT. These mobile accelerator units, which can be transported any day of use to almost any location within a hospital setting, are assembled in a nondedicated environment and used to deliver IORT. Numerous aspects of the design of these new units differ from that of conventional linear accelerators. The scope of this Task Group (TG-72) will focus on items that particularly apply to mobile IORT electron systems. More specifically, the charges to this Task Group are to (i) identify the key differences between stationary and mobile electron linear accelerators used for IORT, (ii) describe and recommend the implementation of an IORT program within the OR environment, (iii) present and discuss radiation protection issues and consequences of working within a nondedicated radiotherapy environment, (iv) describe and recommend the acceptance and machine commissioning of items that are specific to mobile electron linear accelerators, and (v) design and recommend an efficient quality assurance program for mobile systems.

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Section: Introductionmentioning

confidence: 99%

Intraoperative radiation therapy using mobile electron linear accelerators: Report of AAPM Radiation Therapy Committee Task Group No. 72

et al. 2006

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“…The integration of an IORT boost to the whole bladder in a multidisciplinary protocol combining neoadjuvant systemic chemotherapy, preoperative RT, and planned cystectomy has proven to be feasible in the Pamplona's series [44]. The mean sterilization rate of invasive bladder cancer, confirmed in pathologic studies by the cystectomy specimen, was 65%, and seemed to be increased by the addition of neoadjuvant chemotherapy.…”

Section: Bladder Cancermentioning

confidence: 99%

Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

et al. 2017

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Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in gynaecological and genito-urinary cancer including endometrial, cervical, renal, bladder and prostate cancers.Literature search was performed by Pubmed and Scopus, using the words “intraoperative radiotherapy/IORT”, “gynaecological cancer”, “uterine/endometrial cancer”, “cervical/cervix cancer”, “renal/kidney cancer”, “bladder cancer” and “prostate cancer”. Forty-seven articles were selected from the search databases, analyzed and briefly described.Literature data show that IORT has been used to optimize local control rate in genito-urinary tumours mainly in retrospective studies. The results suggest that IORT could be advantageous in the setting of locally advanced and recurrent disease although further prospective trials are needed to confirm this findings.

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“…This method can be applied for treatment of different malignant tumors such as bladder, rectum, sarcoma, pancreas, breast and etc. [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the performance characteristics of some ion chamber dosimeters in high dose per pulse intraoperative electron beam radiation therapy

et al. 2019

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Introduction: Employing routine dosimetry protocols for intraoperative electron beam needs further refinements to obtain reliable results. In this regard, the performance of some cylindrical and parallel plate ion chambers for both relative and absolute dosimetry of intraoperative electron beam has been evaluated. Materials and methods: Four different ion chambers including Semiflex and PinPoint cylindrical chambers as well as Advanced Markus and Roos parallel plate ones were employed for PDD measurement and dose rate determination in reference condition of the electron beam produced by LIAC intraoperative accelerator. The results of PDD measurements were compared with those of Gafchromic EBT2 film. Specific recommendations were followed to determine the chamber correction factors including k s and k Q,Q0 for absolute dosimetry in intraoperative reference condition. Results: There was good agreement between PDDs measured by employed chambers and EBT2 film at all nominal energies. Nevertheless, Advanced Markus chamber had the best performance based on the gamma analysis results. Obtained k Q,Q0 and k s for studied ion chambers largely differed from expected values by TRS-398 protocol. The difference of measured dose rates at 12 MeV energy by investigated chambers was less than 1.1% and Advanced Markus had the best accordance with pre-set dose rate by manufacture. Conclusion: Results showed that ignoring the specific recommended procedures in determining the chamber correction factors causes the overestimation of the measured dose. Therefore, dedicated dosimetry protocol should be developed for high dose per pulse intraoperative electron dosimetry including all of the updated correction factors and deviations from routine ionometric electron dosimetry formalisms. According to the recommendations of TRS-398 and TG-51 protocols,

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Intraoperative and External Preoperative Radiotherapy in Invasive Bladder Cancer

Cited by 17 publications

References 0 publications

Intraoperative radiation therapy using mobile electron linear accelerators: Report of AAPM Radiation Therapy Committee Task Group No. 72

Intraoperative radiation therapy using mobile electron linear accelerators: Report of AAPM Radiation Therapy Committee Task Group No. 72

Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

Evaluating the performance characteristics of some ion chamber dosimeters in high dose per pulse intraoperative electron beam radiation therapy

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