Intraocular pressure lowering effect and structure-activity relationship of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats: Insight on possible link with hypotensive activity

Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats

“…Benzimidazoles are heterocyclic aromatic organic compound having structural analogy to nucleotides found in human body and hence are an important pharmacophore in medicinal chemistry [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] . They are known to exhibit Rho-kinase (ROCK) inhibitory activity and thus could be considered as novel potential class of anti-glaucoma therapeutics [14] , [15] , [16] .…”

“…They are known to exhibit Rho-kinase (ROCK) inhibitory activity and thus could be considered as novel potential class of anti-glaucoma therapeutics [14] , [15] , [16] . Data in this article is to present the effects of benzimidazole-based compounds on IOP of ocular normotensive rats and is supplementary to [1 , 2] . These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole [1] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] .…”

“…The IOP reduction was measured up to 6 h. Data source location Universiti Teknologi MARA, Faculty of Medicine, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan, Malaysia Data accessibility Data is with this article. Related research article This data is supplementary to [1 , 2] …”

Novel Benzimidazole/Hydrazone Derivatives as Promising Anticancer Lead Compounds: Design, Synthesis, and Molecular Docking Study

“…Chemotherapy is the main cancer treatment strategy while patients administered the available chemotherapeutics are suffering undesirable side effects [2] hence, new research studies are stressed by scientists in order to discover new anticancer promising agents. Because of the structure similarity to the naturally occurring purines, some benzimidazole derivatives have proved biological importance; [3] such as: anticancer [4][5][6] (Figure 1), antimicrobial [7][8][9][10], antifungal [11][12][13][14][15], antiviral [18][19][20], anthelmintic [21][22], antihypertensive [23][24][25][26][27], antitubercular [28][29][30][31], antiulcer activity [32], antihistaminic [33] and anti-oxidant [34][35][36]. Imine group (-C=N-) included in hydrazones is considered an essential moiety of fictional group plays essential role in biological system such as mechanism of transformation reaction and racemization ( Figure 2) [37].…”

Design and synthesis of 2‐phenyl benzimidazole derivatives as VEGFR‐2 inhibitors with anti‐breast cancer activity

“…Benzimidazole ring system has emerged to have a great importance as bioactive substructure, owing to structure similarity to the naturally occurring purines (Gaba & Mohan, ). It is inspected to be one of the highest biologically active class of compounds having diverse activities (Amari, Fodili, Nedjar‐kolli, Hoffmann, & Périé, ; Navarrete‐Vázquez et al., ) like antimicrobial (Desai, Pandya, & Vaja, ; Zhang et al., ), anti‐inflammatory (Gaba, Singh, & Mohan, ; Gaba et al., ), antiviral (Dittmer et al., ), antitumor (Padalkar et al., ), anticancer (Omar et al., ), anthelmintic (Alam, Dey, Sharma, Chakraborty, & Kalita, ), antihypertensive (Marcus et al., ), and anti‐hepatitis C virus activity (Vausselin et al., ).…”