Intraocular Pressure in Juvenile Diabetics

Traisman, Howard S.; Alfano, Joseph E.; Andrews, John S.; Gatti, Richard A.

doi:10.1016/0002-9394(67)93071-1

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…We also found that diabetes at the baseline examination was significantly and positively associated with change (increase) in IOP. Diabetes has been found to be associated with increased IOP in other studies, [27][28][29] although the reasons are not known.…”

Section: Discussionmentioning

confidence: 86%

Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study

Klein

2005

British Journal of Ophthalmology

256

158

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Aim: To investigate the relation between change in systemic blood pressures and change in intraocular pressure. Methods: This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baseline and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications. Results: Intraocular pressures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations between changes in systemic blood pressures and changes in intraocular pressure. There was a 0.21 (95% CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increase in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg increase in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pressures of more than 10 mm Hg over 5 years were significantly associated with decreased IOP. Conclusions: Reduced systemic blood pressure is associated with reduced intraocular pressure. This finding should be evaluated in other studies, especially with respect to the possibility of resultant decreased risk of open angle glaucoma. I ntraocular pressure (IOP) has been found to be associated with systemic blood pressure levels in population based studies.1-10 The relation appears to be reasonably consistent across the range of values of IOP and both systolic and diastolic blood pressures. It has been postulated that treatment of hypertension may place the eye at relatively increased risk of visual field deficits because of an imbalance in the relation of blood pressure to IOP.11 This thought has been given credence, in part, because of the clinical dictum that sudden lowering of blood pressure is associated with loss of visual field in some people.12 Blood pressure increases with age in most populations, and medical intervention has been successful in lowering blood pressure and the subsequent risk of the systemic sequelae of high blood pressure. There are limited data as to whether the moderate changes in blood pressure that often accompany treatment for hypertension are associated with synchronous changes in IOP. We evaluated these questions in data from the Beaver Dam Eye Study. METHODSA population based study of people 43-86 years of age (n = 4926) was conducted in Beaver Dam, Wisconsin in 1988-90. Details of the census used to identify and locate study subjects have been published previously.13 A follow up examination was performed 5 years after baseline (n = 3684). Institutional review board approval at the University of Wisconsin Medical School was granted for each phase of the study. Informed consent was obtained from study participants. The tenets of the Declaration of Helsinki were adhered to. During the study evaluations, blood pressures were obtained according to a modification of the Hypertension Detection and Follow-up Program protocol 14 which entails three measurements, ...

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Section: Discussionmentioning

confidence: 86%

Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study

Klein

2005

British Journal of Ophthalmology

256

158

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“…Larsen and colleagues [ 22 ] found lower IOP values during severe hypoglycemia. In addition, Traisman et al [ 23 ] and associates, while assessing IOP in patients with blood glucose values under and above 200 mg/dL, observed higher IOP values in those with glucose levels above 200 mg/dL (mean difference of 1.3 mmHg). Unfortunately, none of these studies sought to determine the association between the magnitude of glucose levels variation and IOP change in diabetic and nondiabetic patients, which hinders a straight comparison with our findings.…”

Section: Discussionmentioning

confidence: 99%

Association between Glucose Levels and Intraocular Pressure: Pre- and Postprandial Analysis in Diabetic and Nondiabetic Patients

Pimentel

Gracitelli

Silva

et al. 2015

Journal of Ophthalmology

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The aim of this study was to evaluate the relationship between glucose levels and intraocular pressure (IOP) fluctuation in diabetic and nondiabetic patients. Seventeen nondiabetic and 20 diabetic subjects underwent a complete ophthalmic examination, capillary glucose testing, and applanation tonometry in two distinct situations: first, fasting for at least 8 hours and, second, postprandial measurements. Baseline glucose levels were higher in diabetic patients (P < 0.001). Postprandial IOP was significantly higher than baseline IOP in diabetic (P < 0.001) and nondiabetic patients (P = 0.006). Postprandial glucose levels were significantly higher than baseline measurements in both diabetic (P = 0.005) and nondiabetic patients (P = 0.015). There was a significant association between glucose levels variation and IOP change in both diabetic patients (R 2 = 0.540; P < 0.001) and nondiabetic individuals (R 2 = 0.291; P = 0.025). There is also a significant association between the baseline glucose levels and IOP change in diabetic group (R 2 = 0.445; P = 0.001). In a multivariable model, the magnitude of glucose level change remained significantly associated with IOP variation even including age, baseline IOP, ancestry, and gender as a confounding factor (P < 0.001). We concluded that there is a significant association between blood glucose levels and IOP variation, especially in diabetic patients.

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“…In several studies, primary open-angle glaucoma was more prevalent among patients with diabetes mellitus than among nondiabetic subjects [2,4,20,22,26,30]. Other investigations revealed that the intraocular pressure of both adult and juvenile diabetic patients was higher than that of a nondiabetic population [19,21,28,37]. Prevalence of diabetes mellitus or a positive glucose tolerance test was higher in patients with primary open-angle glaucoma or in patients with a high intraocular pressure response to topical steroids than in normal subjects [1].…”

Section: Prevalence Of Diabetes Mellitus and Arterial Hypertension Inmentioning

confidence: 99%

Prevalence of diabetes mellitus and arterial hypertension in primary and secondary open-angle glaucomas

Jonas

Gründler

1998

Graefe's Arch Clin Exp Ophthalmol

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Intraocular Pressure in Juvenile Diabetics

Cited by 13 publications

References 5 publications

Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study

Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study

Association between Glucose Levels and Intraocular Pressure: Pre- and Postprandial Analysis in Diabetic and Nondiabetic Patients

Prevalence of diabetes mellitus and arterial hypertension in primary and secondary open-angle glaucomas

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