Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection

Jonas, Jost B.; Degenring, Robert F.; Kreissig, Ingrid; Akkoyun, İmren; Kamppeter, Bernd A.

doi:10.1016/j.ophtha.2004.10.042

Cited by 312 publications

(220 citation statements)

References 41 publications

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“…[13][14][15][16] The most commonly reported complication associated with IVTA injection is elevation of IOP. [17][18][19] The rate of this complication shows wide variation in published studies ranging from 20.8 to 52% of operated eyes. 18,13 The dose of triamcinolone acetonide injected into the vitreous also varies from 4 to 25 mg and this may potentially affect the rate and level of IOP elevation.…”

Section: Discussionmentioning

confidence: 99%

Ocular morbidity associated with intravitreal triamcinolone acetonide

Konstantopoulos¹,

Williams²,

Newsom³

et al. 2006

Eye

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Aim To report on the complications associated with the use of intravitreal triamcinolone acetonide (IVTA) in a tertiary referral hospital setting. Materials and methods A retrospective case series review of all IVTA injections carried out over a period of 30 months. Results One hundred and thirty IVTA injections were performed; nine with limited local follow-up were excluded. Thus, 121 injections (108 patients, 114 eyes) were included in the study. Triamcinolone (4 mg) was used in all cases. Indications were diabetic macular oedema (n ¼ 41 eyes), retinal vein occlusions (n ¼ 27), postoperative cystoid macular oedema (n ¼ 24), exudative age-related macular degeneration (n ¼ 16), and others (n ¼ 6). No intraoperative complications were recorded. Postoperative intraocular pressure (IOP) readings of 22, 28, 35, and 40 mmHg or higher were recorded in 46.5, 29.8, 12.3, and 7.9% of eyes, respectively. IOP elevation was treated with antiglaucoma medication in all but one eye (0.9%) that required trabeculectomy and one (0.9%) that required vitrectomy with cataract extraction for suspected phacoanaphylactic glaucoma. Two eyes (1.8%) developed retinal detachment; both had previously been treated for retinal breaks. One eye (0.9%) developed culture-positive endophthalmitis. Conclusions Significant morbidity is associated with IVTA injection; clinicians should be aware when considering treatment options.

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Section: Discussionmentioning

confidence: 99%

Ocular morbidity associated with intravitreal triamcinolone acetonide

Konstantopoulos¹,

Williams²,

Newsom³

et al. 2006

Eye

View full text Add to dashboard Cite

show abstract

“…7,9 Specially, it has been reported that younger age is a risk factor for a marked IOP rise after intravitreal TA. 2 Therefore, in our clinic, we choose to administrate TA by PST delivery when patients are at a younger age (usually o45 years). However, although intractable glaucoma due to peribulbar corticosteroids was rarely seen, it still occurred.…”

Section: Commentmentioning

confidence: 99%

“…1,2 The most concerned adverse effect of intravitreal injection of TA except for endophthalmitis is elevated intraocular pressure (IOP). Accumulative studies have shown that the incidence of an IOP over 21 mmHg is about 30-40% in patients receiving intravitreal TA.…”

mentioning

confidence: 99%

“…Accumulative studies have shown that the incidence of an IOP over 21 mmHg is about 30-40% in patients receiving intravitreal TA. [1][2][3][4] Although most of these patients can be treated systemically or topically, there was still about 1% with intractable glaucoma must undergo filtering or vitrectomy to normalize IOP. [2][3][4] Posterior sub-Tenon's (PST) injection of steroid is an alternative route with proven effectiveness in resolution of cystoid macular oedema and only few patients developed IOP raised.…”

mentioning

confidence: 99%

“…[1][2][3][4] Although most of these patients can be treated systemically or topically, there was still about 1% with intractable glaucoma must undergo filtering or vitrectomy to normalize IOP. [2][3][4] Posterior sub-Tenon's (PST) injection of steroid is an alternative route with proven effectiveness in resolution of cystoid macular oedema and only few patients developed IOP raised. [5][6][7] Herein, we report a young adult receiving PST injection of TA for central retinal vein occlusion (CRVO) who developed intractable glaucoma despite maximal antiglaucoma medication and surgical excision of the depot TA.…”

mentioning

confidence: 99%

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