Intraocular pressure and myopia progression in Chinese children: the Anyang Childhood Eye Study

Li, Shiming; Iribarren, Rafael; He, Lin; Kang, Meng-Tian; Liu, Luo-Ru; Wei, Shifei; Stell, William K.; Martin, G. Perez; Wang, Ningli

doi:10.1136/bjophthalmol-2017-311831

Cited by 18 publications

(25 citation statements)

References 33 publications

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“…For students with unaided visual acuity 0.3 or worse in either eye, subjective refraction was performed to obtain best-corrected visual acuity by trained optometrists. The cycloplegic procedure referred to the Anyang Childhood Eye Study [10]. Cycloplegia was achieved with two drops of 1% cyclopentolate and 1 drop of Mydrin P at a 5-min interval.…”

Section: Distant Visual Acuitymentioning

confidence: 99%

Prevalence and pattern of refractive error and visual impairment among schoolchildren: the Lhasa childhood eye study

Cui

et al. 2021

BMC Ophthalmol

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Background Early and effective ocular screening may help to eliminate treatable eye disorders. The Lhasa Childhood Eye Study (LCES) revealed the particular prevalence of refractive error and visual impairment in grade one schoolchildren (starting age of 6 years old) in Lhasa. Methods This is a cross-sectional part of school-based cohort study. One thousand nine hundred forty-three children were enrolled (median age, 6.78 years, range, 5.89 to 10.32). Each child underwent general and ocular examinations, including logarithm of the minimum angle of resolution (logMAR) visual acuity, cycloplegic autorefraction, and slit-lamp biomicroscopy evaluation. Multivariate and correlation analyses were performed to evaluate the association between refractive error with gender and ethnics. Results The prevalence of visual impairment (logMAR visual acuity ≥0.3 in the better-seeing eye) of uncorrected, presenting and best-corrected visual acuity (BCVA) was 12.2, 11.7 and 2.7%, respectively. Refractive error presented in 177 (78.0%) out of 227 children with bilateral visual impairment. Myopia (spherical equivalent refractor [SER] ≤ − 0.50 diopter [D] in either eye) was present in 4.7% children when measured after cycloplegic autorefraction. Hyperopia (SER ≥ + 2.00 D) affected 12.1% children. Hyperopia was significantly associated with female gender (P<0.001). Astigmatism (cylinder value ≤ − 0.75 D) was present in 44.8% children. In multivariate regression and correlation analysis, SER had no significant difference between ethnic groups. Conclusion The Lhasa Childhood Eye Study is the first school-based cohort study to reveal the prevalence and pattern of refractive error and visual impairment in Lhasa. Effective strategies such as corrective spectacles should be considered to alleviate treatable visual impairment.

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Section: Distant Visual Acuitymentioning

confidence: 99%

Prevalence and pattern of refractive error and visual impairment among schoolchildren: the Lhasa childhood eye study

Cui

et al. 2021

BMC Ophthalmol

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“…However, in progressive high myopia, especially pathologic myopia, it has been reported that the sclera of these patients was continually prolonged and had higher compliance and, consequently, was more elastic and more sensitive to IOP change. 37 , 51 In summary, we hold the view that lowering the IOP can slow down AL increase, especially in progressive high myopia populations.…”

Section: Evaluations In Clinical Practicesmentioning

confidence: 83%

“…However, in eyes with greater myopia progression, IOP was significantly lower, which indicated that progressing myopic eyes have higher scleral compliance. 37 A multivariate linear regression analysis used in the Anyang University Students Eye Study described that higher IOP is associated with higher myopic refractive error and shorter AL. As the sclera has a certain compliance, below the threshold, the correlation between IOP and AL was negative, while above a certain degree, the correlation was positive.…”

Section: Evaluations In Clinical Practicesmentioning

confidence: 99%

Lowering Intraocular Pressure: A Potential Approach for Controlling High Myopia Progression

Wang

Chen

Liu

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“… 10 , 11 In contrast, others showed an inverse association between IOP and myopia. 12 , 13 We speculate that the inconsistencies in the results occur from the fact that IOP is an influencing factor of ocular perfusion pressure but cannot represent ocular tissue perfusion. 9 …”

Section: Introductionmentioning

confidence: 95%

Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

Bai

Kang

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to report the distribution of mean ocular perfusion pressure (MOPP) and its associated factors in Chinese children. Methods We enrolled 3048 grade 1 students and 2258 grade 7 students of the Anyang Childhood Eye Study in central China. Systolic and diastolic blood pressure (SBP and DBP) were recorded with a digital automatic sphygmomanometer. Intraocular pressure (IOP) was assessed by a non-contact tonometer. MOPP was calculated as 2/3 × (DBP + 1/3[SBP – DBP]) - IOP. Risk factors for myopia were obtained through a questionnaire survey. Results The MOPP was 33.83 ± 6.37 mm Hg (mean ± SD) in grade 1, which was lower than 36.99 ± 6.80 mm Hg in grade 7 ( P < 0.001). Compared with myopic eyes, non-myopic eyes had higher MOPP in grade 7 (37.72 ± 6.72 mm Hg versus 36.58 ± 6.57 mm Hg, P < 0.001) and in grade 1 (33.88 ± 6.29 mm Hg versus 33.12 ± 7.03 mm Hg, P = 0.12). Multivariable analysis showed that higher MOPP was associated with less myopia ( P < 0.001), higher body mass index (BMI; P < 0.001), thinner central corneal thickness ( P < 0.001), less time on near work ( P < 0.001), and more time on sleeping ( P = 0.04). Conclusions MOPP was higher in children of older age, with higher BMI, less time on near work, and more time on sleeping, and was higher in eyes with less myopia. Translational Relevance We found that MOPP might be an indicator for the detection of myopia development.

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Intraocular pressure and myopia progression in Chinese children: the Anyang Childhood Eye Study

Abstract: In this sample of Chinese children, myopia progression over 2 years was inversely related to IOP, suggesting that IOP had essentially no relationship with myopia progression in school children. The lower IOP in progressing myopic eyes may indicate more compliant sclerae.

Cited by 18 publications

References 33 publications

Prevalence and pattern of refractive error and visual impairment among schoolchildren: the Lhasa childhood eye study

Prevalence and pattern of refractive error and visual impairment among schoolchildren: the Lhasa childhood eye study

Lowering Intraocular Pressure: A Potential Approach for Controlling High Myopia Progression

Ocular Perfusion Pressure in 7- and 12-Year-Old Chinese Children: The Anyang Childhood Eye Study

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