Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor

Abstract

Citation: Parrozzani R, Frizziero L, Testi I, et al. Intraocular metastases secondary to breast carcinoma correlates with upregulation of estrogen and progesterone receptor expression in the primary tumor. Invest Ophthalmol Vis Sci. 2016;57:3944-3948. DOI:10.1167/iovs.16-19695 PURPOSE. To compare estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor expression in the primary tumor of patients affected by choroidal metastases from breast carcinoma (BC) versus those with extraocular metastases.METHODS. Eighteen consecutive patients affected by choroidal metastases from BC were included. We defined ER, PR, and HER2 positivity of the primary tumor following standard guidelines. Breast carcinoma molecular subtypes were also identified (luminal A, luminal B, HER2-enriched, and triple negative). Forty consecutive patients affected by metastatic BC without choroidal involvement were included as a control group. RESULTS.The study group and the control group were similar for age, sex, race, histopathologic classification of the primary tumor (ductal, lobular, others), and American Joint Committee on Cancer Tumor-Node-Metastasis stage at the time of primary tumor diagnosis (P > 0.05). Patients affected by choroidal metastases from BC showed a significantly higher expression of ER (P ¼ 0.009) and PR (P ¼ 0.018) receptors in the primary tumor compared with nonchoroidal metastatic BC. Across all patients, the luminal B molecular subtype was related to the presence of choroidal involvement (P ¼ 0.003). Considering luminal tumors only, the luminal B subclassification was also related to the presence of choroidal involvement (P ¼ 0.009).CONCLUSIONS. Choroidal metastases from BC are associated with ER and PR expression in the primary tumor and the luminal B molecular subtype.

Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology

“…A study conducted by Parrozzani et al reported that patients with choroidal metastases are more likely to have an ER-positive and PR-positive primary breast cancer than patients with breast cancer metastasizing to any other location [26]. In a recent cohort description of orbital metastases by Sindoni et al, they were all ER positive [27].…”

Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid

“…CM is reportedly related to the molecular subtype of BC. By comparing 18 patients of BC with CM and 40 patients of BC without CM, Parrozzani et al [ 11 ] suggested that the expressions of PR and ER may, to some extent, be related to the incidence of CM from BC, especially the luminal B molecular subtype. Colleoni et al [ 12 ] reported that patients with HR positive cancer, especially ER positive, had a relatively good prognosis, while they are more likely to be found with metastasis.…”

Clinical features, treatment, and prognosis of 16 breast cancer patients with ocular metastases

“…Breast cancer patients with lung and brain metastases had a higher risk of asymptomatic metastases to the choroid (20). Our results revealed that 12 breast cancer patients had metastases to the eyes and other organs simultaneously, of which 4 were diagnosed to have lung and brain metastases prior to the occurrence of ocular metastases.…”

“…Among these patients who represented an unusually young group, 10 (63%) were ER-positive, 8 (50%) were PR positive, and 3 (6%) were HER2 positive. Raffaele et al (20) have consistently reported that the occurrence of choroid metastases in breast cancer patients is associated with the ER (100%) and PR (88.8%) expression in the primary tumor and with the luminal B molecular subtype (100%). This finding suggests that the receptor expression status and molecular subtype of the primary tumor may have an influence on the metastasis of tumor to the choroid.…”