Intraocular melanomas

Sahel, J; Albert, Daniel M.

doi:10.1007/978-1-4615-3080-0_7

Cited by 14 publications

(17 citation statements)

References 284 publications

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“…However, the age-standardized incidence rates remained fairly stable with only small and irregular changes between 0.61 and 0.79 per 100 000 per year, consistent with values reported in other countries (Sahel et al, 2001). The absence of a rising trend in incidence is seen in Figure 1 and contrasted with the exponential increase in the number of subscribers to mobile telephones in Denmark from 1982 to 1996.…”

Section: Resultssupporting

confidence: 85%

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Mobile phones and malignant melanoma of the eye

Johansen

Boice

et al. 2002

Br J Cancer

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Recently a four-fold increase in the risk of malignant melanoma of the eye was associated with the use of radiofrequency transmitting devices, including mobile phones in Germany. We contrasted the incidence rates of this rare cancer with the number of mobile phone subscribers in Denmark. We observed no increasing trend in the incidence rate of melanoma, which was in sharp contrast to the exponentially increasing number of mobile phone subscribers starting in the early 1980s. Our study provides no support for an association between mobile phones and ocular melanoma.

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Section: Resultssupporting

confidence: 85%

“…The long-term relatively stable incidence rate suggests that the risk factors for this rare cancer, such as dysplastic nevus syndrome, atypical ocular nevi, iris pigmentation and ocular and oculardermal melanocytosis (Sahel et al, 2001) have changed little over the 54 years of incidence data available in Denmark.…”

Section: Discussionmentioning

confidence: 99%

Mobile phones and malignant melanoma of the eye

Johansen

Boice

et al. 2002

Br J Cancer

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“…It has been suggested that the hormonal, physiological and the mechanical changes that are present within the body during or after pregnancy and labor induce or promote the process of malignancy and metastasis (13,17). Capillary and cavernous hemangiomas, although benign, are prone to variations and fluctuation in size during pregnancy.…”

Section: Does Gestation Enhance Tumor Growth?mentioning

confidence: 99%

“…The most common cancer types reported to occur in association with pregnancy are cancer of the breast (11,12) endometrium, uterine cervix, ovary (13)(14)(15), colon and rectum (16), malignant melanoma (17), lymphoma (18), leukemia (19), and endocrine malignancies (16). More sporadically, and probably because of the relative rarity, sarcoma of the bone or soft tissues (16,(20)(21)(22)(23)(24)(25) may present during gestation.…”

Section: Original Articlementioning

confidence: 99%

Soft Tissue and Bone Sarcomas in Association with Pregnancy

Merimsky

Cesne

1998

Acta Oncologica

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“…A large number of blue nevi contain similar mutations (Van Raamsdonk et al 2010), in addition to lesions of Nevus of Ota (also called oculodermal melanocytosis). Nevus of Ota is a risk factor for uveal melanoma, conferring a 4.6% lifetime risk of ocular melanoma (Sahel and Albert 1993).…”

Section: Genetic Mutations Associated With Site-specific Melanomas Uvmentioning

confidence: 99%

Melanoma: Clinical Features and Genomic Insights

Hawryluk

Tsao

2014

Cold Spring Harbor Perspectives in Medicine

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Recent efforts in genomic research have enabled the characterization of molecular mechanisms underlying many types of cancers, ushering novel approaches for diagnosis and therapeutics. Melanoma is a molecularly heterogeneous disease, as many genetic alterations have been identified and the clinical features can vary. Although discoveries of frequent mutations including BRAF have already made clinically significant impact on patient care, there is a growing body of literature suggesting a role for additional mutations, driver and passenger types, in disease pathophysiology. Although some mutations have been strongly associated with clinical phenotypes of melanomas (such as physical distribution or morphologic subtype), the function or implications of many of the recently identified mutations remains less clear. The phenotypic and clinical impact of genomic mutations in melanoma remains a promising opportunity for progress in the care of melanoma patients. There have been many recent advances in our understanding of melanoma, from a greater appreciation of epidemiologic trends and risk factors to an increased understanding of the molecular genomics and biology of melanoma. Studies suggest that a number of molecularly distinct changes have a role in the pathophysiology of melanoma, and melanomas encompass a heterogeneous group when considering many known genomic alterations and diverse clinical phenotypes. To date, there are clinical subtypes or "phenotypes" of melanoma that are associated with specific genomic changes, in addition to many identified genomic mutations that lack a clear clinical correlation.Genomic studies are able to inform us about the disease phenotype, in addition to improving our understanding of disease pathogenesis. The various phenotypes of melanoma are characterized by clinical features, such as bodily distribution or risk factors. Cutaneous, uveal, acral, and mucosal melanomas (Fig. 1) have divergent clinical courses and are associated with distinct mutations, and risk factors such as skin phototype or UV exposure pattern are also associated with distinct alterations in genetic mutations. A melanoma phenotype can also be classified based on histopathologic morphology such as superficial spreading, nodular, desmoplastic, etc. In this review, we examine a number of Editors: Anthony E. Oro and Fiona M. Watt Additional Perspectives on The Skin and Its Diseases available at www.perspectivesinmedicine.org

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Intraocular melanomas

Cited by 14 publications

References 284 publications

Mobile phones and malignant melanoma of the eye

Mobile phones and malignant melanoma of the eye

Soft Tissue and Bone Sarcomas in Association with Pregnancy

Melanoma: Clinical Features and Genomic Insights

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