Intraocular Manifestations of Multiple Myeloma

Sanders, T.E.; Podos, Steven M.; Rosenbaum, Louis J.

doi:10.1001/archopht.1967.00980020791015

Cited by 37 publications

(11 citation statements)

References 18 publications

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“…Other ocular findings including crystal [6, 7, 10, 11]or copper deposits [5, 9]in the cornea and ciliary body cysts [4, 8, 12, 13, 30]were not observed in this series. These are frequently asymptomatic.…”

Section: Discussionmentioning

confidence: 63%

“…This increases the plasma viscosity to such a point that the microcirculation is impaired. Funduscopy generally reveals dilated, tortuous veins, sludging of retinal vessels, retinal hemorrhage, microaneurysms or cotton wool spots [2, 4, 8, 14, 15, 26, 27, 28]. Knapp et al [3]found that up to 66% of the patients with MM showed these posterior pole pathologies, but this was found in only 10% of our patients.…”

Section: Discussionmentioning

confidence: 74%

“…Common ocular findings include crystal or copper deposition in the cornea, ciliary body cysts and retinopathy of hyperviscosity [5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. These findings tend to be asymptomatic and in some cases, such as ciliary body cysts, may only be found at autopsy [3].…”

Section: Introductionmentioning

confidence: 99%

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Ophthalmic Manifestations of Multiple Myeloma

et al. 2005

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Purpose: To describe ophthalmic manifestations in a series of patients with multiple myeloma (MM) and review the literature. Design: Retrospective case series. Methods: Review of all cases with ophthalmic manifestations of MM seen at the Department of Ophthalmology, Royal Adelaide Hospital, between 1987 and 2002. Results: Of all patients with MM who were managed at the Royal Adelaide Hospital in the study period, only 8 were referred to the Ophthalmology Department with ophthalmic manifestations. Five males and 3 females with a mean age of 61.25 years (range 42–78) who exhibited ophthalmic manifestations were studied. Six patients (75%) had known MM at the time of their ophthalmic evaluation. Four patients (50%) had neuro-ophthalmic symptoms resulting in diplopia or visual disturbances. Three patients (37.5%) presented with orbital involvement and 1 (12.5%) with hyperviscosity retinopathy. Five patients (62.5%) died within 2 months of their ophthalmic presentation. Conclusion: Ophthalmic manifestations of MM are uncommon and diverse. They may appear at the initial presentation of the disease or occur late in the disease process. Awareness of the possible manifestations may lead to an earlier diagnosis and have a positive influence on the disease course.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 74%

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Ophthalmic Manifestations of Multiple Myeloma

et al. 2005

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“…[6] Macroglobulinaemia Waldenstrom Ashton et al [28], Carr and Henkind [29], Sanderset al [30] Chronic leukaemia Duke et al [24], Schmidt and Möbius [27], Jampol et al [26] Angiomatosis retinae Michaelson and Benezra [7], Schmidt and Neumann [33] Macroglobulinaemia (Waldenstrom) Ashton et al [28] Multiple myeloma Sanderset al [30] Sturge-Weber syndrome Morse |99|…”

Section: Metabolic Diseasesmentioning

confidence: 99%

“…Mi cro-aneurysms are seen most frequently in the retinal periphery and midperiphery [29]. Mi cro-aneurysms can also occur in multiple mye loma [30].…”

Section: Peripheral Micro-aneurysmsmentioning

confidence: 99%

Retinal Telangiectasis and Proliferation of the Retinal Vessels in a Family

Schmidt¹,

Soriano²

1993

Ophthalmologica

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A 20-year-old woman presented with a marked proliferative retinopathy of the entire central region of the retina in both eyes, with veil-like epiretinal gliovascular membranes and isolated spots of haemorrhaging. The outer region of the retina was unremarkable. Her 49-year-old mother showed perimacular telangiectases in both eyes. The vascular system of both patients were medically sound, and, in particular, the blood pressure, blood sugar and blood picture were normal, with nc signs of heart, kidney, lung or liver disease. The first patienl had been a heavy smoker for 6 months, and the second did noi smoke. The 84-year-old mother of the second patient was blind following bilateral Horton’s temporal arteritis.

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Retina and Optic Nerve

Campbell¹

1966

Archives of Ophthalmology

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Intraocular Manifestations of Multiple Myeloma

Cited by 37 publications

References 18 publications

Ophthalmic Manifestations of Multiple Myeloma

Ophthalmic Manifestations of Multiple Myeloma

Retinal Telangiectasis and Proliferation of the Retinal Vessels in a Family

Retina and Optic Nerve

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