Intraocular Involvement in Burkitt's Lymphoma

Karp, Louis A.; Zimmerman, Lorenz E.; Payne, Titus

doi:10.1001/archopht.1971.00990050297009

Cited by 33 publications

(3 citation statements)

References 18 publications

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“…It is now recognized to occur in three major variants. The endemic (African) form occurs in regions of equatorial Africa, in association with EBV infection in 95% of cases, and commonly involves facial bones [3,4]. The immunodeficiency-associated form occurs as a manifestation of human immunodeficiency virus infection and acquired immunodeficiency syndrome [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…BL is endemic in certain regions of equatorial Africa, where it commonly involves facial bones, such as the mandible, maxilla and orbit, and can invade adjacent orbital soft tissue structures, such as the eye [3,4]. In the sporadic form of the disease that occurs in non-endemic areas around the world, most commonly in developed countries, patients usually present with an abdominal mass that frequently involves the ileocecal region of the bowel [5]; ocular or orbital involvement is rare [6].…”

Section: Introductionmentioning

confidence: 99%

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Unusual presentation of sporadic Burkitt’s lymphoma originating from the nasal septum: a case report

Aslan

2013

J Med Case Reports

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IntroductionBurkitt’s lymphoma is a highly aggressive, small, non-cleaved B-cell non-Hodgkin's lymphoma. In the sporadic form of the disease that occurs in non-endemic areas around the world, most commonly in developed countries, patients usually present with an abdominal mass that frequently involves the ileocecal region of the bowel; ocular or orbital involvement is rare. Primary disease of the sinuses is uncommon and, to the best of our knowledge, that of the anterior septum has never been described. We report the diagnosis and successful management of Burkitt’s lymphoma originating from the nasal septum in a male patient.Case presentationAn otherwise healthy 78-year-old Caucasian man who did not smoke cigarettes was admitted to our Ear, Nose and Throat outpatient clinic with the complaint of nasal obstruction due to left-sided nasal septal thickening. Paranasal computerized tomography revealed a well-circumscribed solid mass originating from his anterior nasal septum and obstructing his airway. The final diagnosis of Burkitt’s lymphoma was verified by immunohistochemical studies. Our patient had a good clinical outcome after chemoradiotherapy, with no problems reported to date in the second year of follow-up.ConclusionWe provide what we believe to be the first report of a case of sporadic Burkitt’s lymphoma involving the nasal septum, and describe the efficacy of first-line chemotherapy. Being an original case report with broader clinical impact across more than one area of medicine, this case presentation has the potential to significantly advance our understanding of Burkitt’s lymphoma and we emphasize the need to include this disease in the differential diagnosis of patients presenting with a nasal septal mass.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unusual presentation of sporadic Burkitt’s lymphoma originating from the nasal septum: a case report

Aslan

2013

J Med Case Reports

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“…According to previous studies, both acute and chronic leukemia can cause leukemic retinopathy, although acute leukemia is the main cause of this condition. [ 1 , 2 ] The intraocular manifestations of leukemia are common, [ 1 – 8 ] whereas the intraocular manifestations of leukemic retinopathy are diverse. Previously reported findings that are associated with this conditions included venous congestion, retinal edema, hemorrhages, optic nerve infiltrates, and nonspecific uveitis.…”

Section: Introductionmentioning

confidence: 99%

Acute bilateral retina hemorrhages beneath internal limiting membrane

Lyu

Zhang²,

Gao³

2018

Medicine

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Rationale:Leukemia is a common hematologic disease that causes various systemic complications, such as ophthalmological disorders. The venous congestion is considered to be the main clinical sign that occurs during the initial stage of the disease, whereas white-centered hemorrhages are the most typical manifestations in leukemic retinopathy. These complications usually manifest when the disease presents with clinical and hematological symptoms. In the present study, we report a patient who was diagnosed with leukemic retinopathy. The initial signs of this disease were bilateral hemorrhages that occurred during complete clinical remission. Previous studies regarding this condition are quite rare.Patient concerns:We report a 26-year-old man who was diagnosed with leukemic retinopathy and exhibited the initial signs of the disease, namely bilateral hemorrhages with a distinct appearance beneath the internal limiting membrane. In addition, flame-shaped hemorrhages were observed surrounding the optic discs and/or along the vessels in the absence of venous congestion. All these changes were present during complete clinical remission.Diagnoses:Bilateral acute leukemic retinopathy, acute lymphoblastic leukemia (pro-B lymphocyte, BCR-ABL chimeric gene-positive).Interventions:Clinical remission was achieved following effective systemic chemotherapy that was applied for leukemia in the hematology department. A dynamic observation was applied actively in the absence of surgery and/or medical treatment for ophthalmologic treatment.Outcomes:Best corrected visual acuity was 20/40 in the right eye and 20/60 in the left eye, which was considerably better than those noted at the initial visit of the patient (20/250 in the right eye and 20/400 in the left eye).Lessons:The cautious expectant treatment is safe and helpful for acute leukemic retinopathy. A long-term follow-up is inevitable. Effective systemic chemotherapy that is required for leukemia treatment can achieve clinical remission, which might be helpful in controlling the pathological changes of the eyes.

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