Intraocular Biopsy: An Evaluation*

Sanders, T.E.

doi:10.1016/0002-9394(53)92284-3

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…Transscleral biopsy directly into the tumour has proved to be too hazardous because of the danger of extrascleral spread of tumour cells and the subsequent increased possibility of orbital recurrence followed by a graver prognosis (Jensen & Andersen 1959;Karcioglu et al 1985;Makley 1967;Sanders 1953;Shields 1977). Char et al (1989) used both biopsy directly through the sclera into the tumour and the transvitreal approach, and meticulously dried the area of needle perforation with neurosurgical pads.…”

Section: Discussionmentioning

confidence: 99%

Transvitreal retino‐choroidal biopsy of suspected malignant lesions of the choroid

Jensen

Prause

Scherfig

1997

Acta Ophthalmologica Scandinavica

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The cases of transvitreal retino-choroidal (TVRC) biopsy from 1987 to 1994 were assembled in order to examine the efficiency, complications and risks to patients. Of 92 biopsies 91 had sufficient material for diagnosis. Eighty (87%) contained malignant tissue, whereas 10 cases were negative and two unsuccessful. Tumours of appropriate size were treated by brachytherapy. Twenty-three large tumours were enucleated primarily. Eight irradiated eyes had to be removed. In 31 cases, therefore, it was possible to examine the whole tumour for changes caused by the biopsy and to compare the typing of the biopsy with that of the whole tumour. In the irradiated eyes histologically viable tumour cells remained mostly in the inner part of the tumour. Scleral necrosis was not found. The technique used appears to be safe. Histological verification is highly recommended before any conservative therapy, inter alia to obtain true statistics of therapeutic results.

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Section: Discussionmentioning

confidence: 99%

Transvitreal retino‐choroidal biopsy of suspected malignant lesions of the choroid

Jensen

Prause

Scherfig

1997

Acta Ophthalmologica Scandinavica

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“… Fine-needle aspiration biopsy (FNAB) [ Fig. 1 ][ 2 ] Surgical incisional biopsy Surgical excisional biopsy. …”

Section: Biopsy Techniquementioning

confidence: 99%

“…[ 4 ] The various indications requiring a biopsy include rapidly enlarging iris mass, iris nevus, iris melanocytoma, primary iris melanoma, iris metastatic melanoma, iris pigment epithelial adenoma, and iris cyst. [ 2 ]…”

Section: Anterior Segment Tumor Biopsy Techniquesmentioning

confidence: 99%

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Biopsy techniques for intraocular tumors

Rishi

Dhami

Biswas

2016

Indian J Ophthalmol

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Biopsy involves the surgical removal of a tissue specimen for histopathologic evaluation. Most intraocular tumors are reliably diagnosed based on the clinical evaluation or with noninvasive diagnostic techniques. However, accurately diagnosing a small percentage of tumors can be challenging. A tissue biopsy is thus needed to establish a definitive diagnosis and plan the requisite treatment. From fine-needle aspiration biopsy (FNAB) to surgical excision, all tissue collection techniques have been studied in the literature. Each technique has its indications and limitations. FNAB has been reported to provide for 88–95% reliable and safe ophthalmic tumor diagnosis and has gained popularity for prognostic purposes and providing eye conserving treatment surgeries. The technique and instrumentation for biopsy vary depending upon the tissue involved (retina, choroid, subretinal space, vitreous, and aqueous), suspected diagnosis, size, location, associated retinal detachment, and clarity of the media. The cytopathologist confers a very important role in diagnosis and their assistance plays a key role in managing and planning the treatment for malignancies.

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“…2 However, these invasive techniques may increase the risk of extraocular tumor spread and orbital seeding. 3,4 We present a case of choroidal metastasis from recurrent breast cancer with subsequent tumor seeding over sclerotomy wounds following pars plana vitrectomy.…”

Section: Introductionmentioning

confidence: 99%

Tumor seeding after diagnostic vitrectomy for choroidal metastasis in breast cancer

Kung

Lin

2012

Journal of the Chinese Medical Association

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Choroidal metastasis is the most common type of intraocular tumor in adults, and in females the most common primary site is the breast. We report a case of unilateral choroidal metastasis with exudative retinal detachment as the initial presentation of recurrent breast cancer, and subsequent ophthalmic metastasis following diagnostic vitrectomy. A 49-year-old woman with a 7-year-history of well-treated bilateral breast cancer had been suffering from blurred vision in the left eye for 1 week. Ocular examination was normal except for superotemporal retinal detachment in the left eye. Neither retinal break nor choroidal mass was seen. The patient received scleral buckling and pneumatic retinopexy without significant improvement. Fluorescein angiography revealed a suspected choroidal metastasis in the left eye, but ocular ultrasonography did not show a visible choroidal mass. Two consecutive diagnostic vitrectomies with cytology could not confirm malignancy. A systemic workup was also negative. Six months later, two tumor masses were noted over two of the sclerotomy wounds of the left eye. Pathology showed adenocarcinoma compatible with invasive ductal carcinoma of the breast. Ocular metastasis may present as infiltrative choroidal lesions with exudative retinal detachment without a visible mass. Invasive procedures, such as fine-needle aspiration biopsy and diagnostic vitrectomy, may risk tumor seeding.

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Intraocular Biopsy: An Evaluation*

Cited by 18 publications

References 8 publications

Transvitreal retino‐choroidal biopsy of suspected malignant lesions of the choroid

Transvitreal retino‐choroidal biopsy of suspected malignant lesions of the choroid

Biopsy techniques for intraocular tumors

Tumor seeding after diagnostic vitrectomy for choroidal metastasis in breast cancer

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