Intraocular Antiviral Penetration

Species Differences in the Metabolism and Disposition of Antiviral Nucleoside Analogues: 1. Acyclovir

“…There was little systemic delivery of ACV, as determined by levels in plasma, at 2 and 7h post-injection (Schulman et al, 1987). In another study, a mean peak ACV level of 1.7 fLg rnl" was detected in the aqueous humour after the topical application of 3% ophthalmic ointment to patients prior to cataract extraction (Poirier et al, 1982). After oral administration of 5 doses of 400 mg to patients due for cataract surgery, the mean ACV level in the aqueous humour was 0.73 fLg mr', approximately 40% of the corresponding plasma level (Hung et al, 1984).…”

Treatment of Pseudodendrites in Herpes Zoster Ophthalmicus With Topical Ganciclovir 0.15% Gel

“…However, severe ocular toxicity, allergic reaction to the preservative thimersol, and low corneal penetration limit its use. 7,27 Ganciclovir acts only on infected cells and thus has low toxicity and better efficacy. 20 In brief, topical ganciclovir gel used 5 times a day initially until corneal lesions resolve and then tid or bid for 1 week to 2 months, depending on disease activity, is successful in treating persistent or recurrent pseudodendrites in HZO.…”

Rapid Diagnosis of Herpetic Infections by Immunoperoxidase Method (With 1 color plate)

“…Moreover, the immediate practical implication o fa posi tive PAP-stain in the button could be the selection of those patients who would benefit from a prophylactic antiviral treatment after grafting. Since virus has been shown in the deep stromal layers, preference should be given to an antiviral drug known to pene trate the cornea such as acyclovir [17].…”