Intranodal Palisaded Myofibroblastoma in a Submandibular Lymph Node

Bouhajja, Leila; Jouini, Raja; Khayat, Olfa; Koubaa, Wafa; Mbarek, C.; Brahim, Ehsen Ben; Chedly-Debbiche, Achraf

doi:10.1155/2017/7121485

Cited by 5 publications

(9 citation statements)

References 12 publications

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“…IPM usually presents as a painless, slow‐growing inguinal mass, which has been diagnosed in a wide age range (second to eighth decade). It is most commonly diagnosed in inguinal lymph nodes with rare cases reported in mediastinal, submandibular, and retroperitoneal lymph nodes . To our knowledge, our case is the first report of IPM in a para‐esophageal lymph node.…”

Section: Discussionmentioning

confidence: 69%

Intranodal palisaded myofibroblastoma of para‐esophageal lymph node: Case report with cytologic and histologic findings

Tipps

Hasteh

et al. 2019

Diagnostic Cytopathology

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Intranodal palisaded myofibroblastoma is a rare lymph node mesenchymal neoplasm that most commonly arises in inguinal lymph nodes. There is limited data about cytologic features of this tumor and its diagnostic pitfalls. The combination of bland appearing spindle cells, fibrillary matrix, and hemosiderin pigments are the characteristic features of this neoplasm in cytologic specimens. K E Y W O R D Sfine-needle aspiration, intranodal palisaded myofibroblastoma, lymph node cytology, spindle cell neoplasm

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Section: Discussionmentioning

confidence: 69%

Intranodal palisaded myofibroblastoma of para‐esophageal lymph node: Case report with cytologic and histologic findings

Tipps

Hasteh

et al. 2019

Diagnostic Cytopathology

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“…The most frequent location is the inguinal lymph nodes, 15 however, cervical, 16 submandibular, 5,15 axillar, 4 mediastinal, 10,17 and retroperitoneal 18 nodes have also been involved. Most cases affect men between the aged of 40 and 60 15 . Rahimi et al reported a pediatric case 19 .…”

Section: Discussionmentioning

confidence: 99%

Cytopathological findings of intranodal palisaded myofibroblastoma: Case report and review of the literature

Pena‐Burgos

Tapia-Viñe

Rodríguez-García

et al. 2023

Diagnostic Cytopathology

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Introduction Intranodal palisaded myofibroblastoma (IPM) is an exceedingly rare benign mesenchymal tumor of the lymph nodes. Magnetic resonance imaging (MRI) findings are unspecific, which may present diagnostic challenges to fine‐needle aspiration cytology (FNAC). The histological and immunohistochemical features of IPM are unique. Case Report A previously healthy 40‐year‐old male patient presented a slow‐growing solitary left inguinal mass. FNAC revealed clustered cells within a metachromatic stroma, single spindle cells without atypia, hemosiderin pigment, and siderophages. An MRI showed a central hyperintense septum in fat‐suppressed, T2‐weighted sequences. The excised lymph node contained central haphazard fascicles of spindle cells with focal nuclear palisading, hemosiderin pigment, extravasated erythrocytes, and hemorrhagic areas. Vimentin and smooth muscle actin were diffusely positive. Amianthoid collagen fibers were not clearly observed. Conclusion IPM is an extremely rare mesenchymal benign intranodal tumor that should be included in the differential diagnosis of spindle cell lesions in the inguinal region.

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“…IPM is a relatively rare intranodal mesenchymal tumor of smooth muscle fibers or myofibroblasts, typically presenting in the inguinal nodes and infrequently at other sites such as cervical [ 6 ], submandibular [ 7 , 8 ], supraclavicular [ 9 ], axillary [ 10 ], mediastinal [ 11 ], and retroperitoneal nodes [ 12 ]. Although mostly seen in middle-age, IPM can affect a broad age group (19–71 years) [ 10 ], with a single case reported in an infant [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Intranodal Palisaded Myofibroblastoma: A Diagnostic Differential for Inguinal Lymphadenopathy

Haddad

Marwan

2021

Am J Case Rep

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Patient: Male, 48-year-old Final Diagnosis: Intranodal palisaded myofibroblastoma Symptoms: Inguinal lump Medication: — Clinical Procedure: Lumpectomy Specialty: Pathology • Surgery Objective: Rare disease Background: Benign tumors of the lymph nodes are rare and are not usually considered in the differential diagnosis in cases of lymphadenopathy because reactive hyperplasia, lymphoma, and metastatic carcinoma are the most likely causes of enlarged nodes. Intranodal palisaded myofibroblastoma (IPM) is a very rare benign mesenchymal tumor of the lymph nodes most often affecting but not limited to the inguinal region, with up to 92 cases reported in the English literature. The cell of origin is the intranodal differentiated smooth muscle cell or myofibroblast. Although the pathophysiology of IPM remains unclear, theories about viral oncogenesis and mutational changes in the β-catenin gene with subsequent abnormal expression of β-catenin and cyclin D1 have been raised. Case Report: We report a case of IPM in a 48-year-old man who presented with a mass in the left groin, with inconclusive imaging. The typical histologic findings of smooth muscle actin, cyclin D1, and β-catenin positive intranodal spindle cell proliferation with characteristic palisades, amianthoid fibers, collagenous bodies, lack of atypia, and very low mitotic count, together with characteristic profile on ancillary testing, confirmed the diagnosis. In addition to staining with smooth muscle actin, cyclin D1 and β-catenin, immunohistochemical studies showed focal positivity with desmin, a finding previously reported in 2 of the published cases. Surgical excision is usually curative, with a 6% recurrence rate and no reported cases of locally aggressive disease or malignant transformation. Conclusions: Although rare, IPM should be included in the differential diagnosis of isolated lymphadenopathy.

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Intranodal Palisaded Myofibroblastoma in a Submandibular Lymph Node

Cited by 5 publications

References 12 publications

Intranodal palisaded myofibroblastoma of para‐esophageal lymph node: Case report with cytologic and histologic findings

Intranodal palisaded myofibroblastoma of para‐esophageal lymph node: Case report with cytologic and histologic findings

Cytopathological findings of intranodal palisaded myofibroblastoma: Case report and review of the literature

Intranodal Palisaded Myofibroblastoma: A Diagnostic Differential for Inguinal Lymphadenopathy

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