Intranephronic Calculosis in Surgical Biopsies of Human Kidney

Boyce, William H.; Willard, John H.; Prater, T

doi:10.1159/000394960

Cited by 3 publications

(3 citation statements)

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“…Microscopic focal calcification widely distributed within the renal parenchyma is frequently seen in histological examination of the kidney (Anderson, 1969;Boyce and Willard, 1972;Bury et al, 1976). Whilst this lesion is almost invariably present in stone-formers, it is not uncommon in the nonstone-former as well (Anderson, 1979).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Experimental Nephrocalcinosis with a Prostaglandin Synthetase Inhibitor

Buck

Leaker

et al. 1983

British Journal of Urology

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Nephrocalcinosis was induced in a group of experimental rats by means of intraperitoneal injections of 10% calcium gluconate. Two further groups of rats were treated with indomethacin and flurbiprofen (Froben) before receiving the i.p. calcium gluconate, to study the effects of prostaglandin inhibition on the process of renal parenchymal calcification. Tissue calcification was studied by means of contact microradiography and histology. Quantitative calcium analysis was by means of energy dispersive analysis of X-rays (EDAX). There was a marked inhibition of cortical nephrocalcinosis and a significantly reduced calcium concentration (P less than 0.005) in the animals treated with a prostaglandin inhibitor compared with the animals given i.p. calcium gluconate alone. This study suggests that prostaglandins are involved in the process of renal parenchymal calcification and may be aetiologically significant in the pathogenesis of stone formation.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Experimental Nephrocalcinosis with a Prostaglandin Synthetase Inhibitor

Buck

Leaker

et al. 1983

British Journal of Urology

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“…In Anderson's series the calcium phosphate was present within the interstitial tissues and the epithelial cells of the renal tubules, sometimes extending into the lumen; the loop of Henle and the collecting tubules were most frequently involved. Boyce (1972) in a study of biopsies of human kidney found Periodic Acid Schiff (PAS) positive material, usually with concentric laminar structure and containing calcium in significant quantities, within the lumen of the nephron. He considered that the origin of this material was in the proximal renal tubule and that there was subsequent migration to the collecting ducts.…”

Section: Discussionmentioning

confidence: 99%

Calcium‐47 Absorption in Urolithiasis

Blacklock

Macleod

1974

British Journal of Urology

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An association between high urinary calcium and calcium urolithiasis was described by Flocks in 1939 but subsequent work has fallen short of establishing the exact relationship between these 2 phenomena. In a group of patients forming calcium-containing renal stones, Melick and Henneman (1958) found that 32% had hypercalciuria. Similar findings have been made by others. Whilst an excessive urinary calcium is present in other specific diseases, hypercalciuria as a phenomenon occurring in the absence of any of these was described by Albright et al. (1953). This syndrome of idiopathic hypercalciuria was defined as the occurrence of a high urinary calcium in association with normal serum calcium, a tendency to hypophosphataemia and renal stone formation and it has since been recognised by others.Caniggia, Gennari and Cesari (1965) suggested that the hypercalciuria was primarily absorptive in origin. Peacock, Hodgkinson and Nordin (1967) showed the importance of dietary calcium in demonstrating hypercalciuria, suggesting that the hypercalciuria in stone formers was probably due to excessive absorption of calcium. An implication of this was that idiopathic stone formers were largely drawn from that segment of the population in which absorption and therefore urinary excretion of calcium was above average. This paper is concerned with the study of a group of stone formers and recurrent stone formers in the Royal Navy in whom intestinal calcium absorption has been measured by arm counting using calcium-47 (47Ca).In the past, techniques for assessing calcium absorption have required the patient to be in hospital and on a strict metabolic regime and have also required accuracy in the timing and collection of urine, faecal and blood samples. With the availability of 47Ca, a gamma-emitting radio-nuclide with a half-life of 4.53 days, a relatively simple and accurate method of measuring calcium absorption has become available using external scintillation counting (Curtis, Fellows and Rich, 1967; Wills et al., 1970;Macleod, 1971).

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“…Other authors have already suggested that microlith formation in the interstitium or the tubular system of the kidney is controlled by calciuretic hormones [1,4]. renal cortex (hydronephrosis) results in a significant increase in thromboxane synthesis [28],…”

Section: Introductionmentioning

confidence: 99%