Intranasal Tranexamic Acid Treatment for Severe Epistaxis in Hereditary Hemorrhagic Telangiectasia

A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial

“…Corresponding values in the study of Tibbelin et al are 11% and 31%. Klepfish et al [13] reported a marked decline in the intensity of epistaxis controlling within minutes after using tranexamic acid in a patient with hereditary hemorrhagic telangiectasia, and after years, he almost stopped using iron supplement and blood transfusions almost concomitantly. Sabba et al [7] reported an improvement in treating 3 cases of intractable epistaxis in patients with hereditary hemorrhagic telangiectasia with high doses of tranexamic acid administered orally.…”

The effect of intravenous tranexamic acid on blood loss and surgical field quality during endoscopic sinus surgery: a placebo-controlled clinical trial

“…Of particular interest is the increasing use of tranexamic acid by oral surgeons in the form of mouthwash for dental extractions [7,8] and in the management of epistaxis with hereditary hemorrhagic telangiectasia [9,10]. Only two studies have reported the efficacy of topical [11] and oral [12] forms of tranexamic acid in achieving hemostasis and improving the surgical field in nasal surgeries, including FESS.…”

Hereditary hemorrhagic teleangiectasia: the topical problems of diagnostics and surgical treatment

“…Для этих целей ис пользуются различные группы медикаментов: лу бриканты (физиологический раствор, мази с анти биотиками), мази/кремы с гормональными препара тами, антифибринолитики [57][58][59][60]. Хирургическое лечение включает лазерные, химические и электри ческие методы эндоназальной коагуляции, дермо пластику перегородки носа (пересадка кожи или буккальной слизистой), эмболизацию носовой арте рии и закрытие носовой полости (операция Янга) [57,[61][62][63][64][65][66].…”