Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-κB-dependent inflammation process in a mouse model of Parkinson's disease

Anitua, Eduardo; Pascual, Consuelo; Pérez‐González, Rocío; Orive, Gorka; Carro, Eva

doi:10.1016/j.jconrel.2015.02.030

Cited by 52 publications

(42 citation statements)

References 60 publications

(73 reference statements)

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“…PRP also has an anti-inflammatory effect in nervous tissue and can attenuate inflammation in mouse models of neurodegenerative diseases 47,48 . Moreover, it can reduce MN swelling and reduce the subsynovial connective tissue thickness within the carpal tunnel in a rabbit model of MN injury 45 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

Trull-Ahuir

Sala

Chismol-Abad

et al. 2020

Sci Rep

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The purpose of this study is to evaluate the efficiency of local platelet-rich plasma (PRP) injection as an adjuvant treatment after carpal ligament release. We conducted a prospective randomized, tripleblinded, controlled trial. Fifty participants with mild to extreme carpal tunnel syndrome (CTS) were randomly assigned either to the PRP (n = 25) or the platelet-poor plasma (PPP, n = 25) group. After performing open surgical release of the carpal ligament, the inside of the carpal tunnel was irrigated with 3 mL of PRP or PPP according to each participant's group allocation. The primary outcome was hand grip strength (HGS). Secondary outcomes were the time taken off work after surgery (in days) and scores on the Wong-Baker Faces Scale, Boston Carpal Tunnel Questionnaire, and Southampton Wound Assessment Scale. We evaluated patients before treatment and at 6-weeks. As expected, the pain levels, symptom severity, and functional status improved in all the patients after surgery. However, intragroup analysis revealed that only the participants in the PRP group had regained their pre-operative HGS levels at 6-weeks follow-up. These findings indicate that PRP is an effective adjuvant treatment in patients with mild to severe CTS who require surgery. Carpal tunnel syndrome (CTS), which affects approximately 3% of the general adult population 1 , is the most commonly diagnosed upper limb peripheral entrapment neuropathy 2. CTS is characterized by compression of the median nerve (MN) at the wrist as it passes through the carpal tunnel 3 and typical symptoms include numbness, paresthesias, and pain in areas innervated by the MN. In more severe cases, weakness and atrophy of the thenar muscles (innervated by the MN) can occur which in turn, usually affects the work productivity and quality of life of the affected patient 4-6. Depending on the severity of the symptoms, treatments for CTS may be conservative (including the use of medications, a night splint, steroid injections, or physical therapy) or require surgical intervention. Surgical decompression of the carpal tunnel by transection of the transverse carpal ligament is the standard treatment for patients with muscle atrophy, or whose symptoms do not respond to conservative therapies 2,7. Carpal tunnel decompression is a well-established surgical treatment for CTS whose reported success rate and levels of patient satisfaction are high 8. Nonetheless, this technique is not exempt from potential complications including: sensitive scar areas, persistent symptoms, neurovascular injury, wound complications, bleeding, pillar pain (pain adjacent to the ligament release site), and reduced grip strength 9,10. Therefore, adjuvant surgical treatments are worth exploring. Platelet-rich plasma (PRP) is an autologous blood product comprising concentrated platelets and several growth factors (including transforming growth factor-β, platelet-derived growth factor, epidermal growth factor, vascular endothelial growth factor, insulin-like growth factor-1, fibroblast growth factor, hepatoc...

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Section: Discussionmentioning

confidence: 99%

Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

Trull-Ahuir

Sala

Chismol-Abad

et al. 2020

Sci Rep

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“…Moreover, the receptor area of the scalp will probably present some physiological features such as perivascular inflammation and reduced capillary network that may hinder the survival and viability of the FTUs once reimplanted. Intradermal application of PRGF could counteract this suboptimal environment as it has been reported not only to behave as an anti‐inflammatory agent via the attenuation of the nuclear factor κB pathway but also as an strong angiogenic inductor thanks to specific growth factors such as VEGF, IGF, and FGFb that promote angiogenesis mediated hair regrowth …”

Section: Discussionmentioning

confidence: 99%

The effect of plasma rich in growth factors combined with follicular unit extraction surgery for the treatment of hair loss: A pilot study

Navarro¹,

Pino

Martínez‐Andrés³

et al. 2017

J of Cosmetic Dermatology

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“…Anti-inflammatory action of PRP is associated with an inhibition of nuclear transcription factor-kB (NF-kB) pathway, which was observed after culturing astrocytes with PRP supernatants [16]. Some of the GFs such as HGF, IGF-1, PDGF and TGF-β delivered in a sustained way after PRP infiltrations are closely related with these effects [15].…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Platelet-Rich Plasma for Injured Peripheral Nerves: Biological Repair Process and Clinical Application Guidelines

Sánchez¹,

Garate²,

Bilbao³

et al. 2019

Demystifying Polyneuropathy - Recent Advances and New Directions

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Platelet-rich plasma (PRP) is a biological therapy that uses the patient's own blood to obtain products with a higher platelet concentration than in blood. It provides a transient fibrin scaffold as a controlled drug delivery system of growth factors suitable for regenerative medicine. PRP has been used as medical strategy to treat diverse types of injuries in the field of orthopedics, including peripheral nerve lesions. In vitro and in vivo studies showed the neuroprotective, neurogenic and neuroinflammatory modulator effect of PRP. In addition, it has been demonstrated clinically that PRP infiltrations improve clinical symptoms and enhance the sensory and motor functional nerve muscle unit recovery. Potential effects of PRP could be applied in treatments for neuropathies, as conservative treatment by means of nerve ultrasound-guided infiltrations or as biological adjuvant during surgery.

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Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-κB-dependent inflammation process in a mouse model of Parkinson's disease

Cited by 52 publications

References 60 publications

Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

The effect of plasma rich in growth factors combined with follicular unit extraction surgery for the treatment of hair loss: A pilot study

Platelet-Rich Plasma for Injured Peripheral Nerves: Biological Repair Process and Clinical Application Guidelines

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