Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach

Zhu, Ruida; Liu, Chao; Li, Ting; Xu, Zhenhua; Fung, Bowen J.; Feng, Chunliang; Wu, Haiyan; Luo, Yi; Wang, Li

doi:10.1016/j.psyneuen.2019.06.016

Cited by 19 publications

(8 citation statements)

References 92 publications

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“…Accumulative evidence indicated that the OT influences human behavior (56) and brain activities (57)(58)(59). Since the previous behavioral results are mixed on whether OT sharpens or blurs self-other distinction (36,60,61), in the present study, participants make judgements in the self-other differentiation task with morphed faces.…”

Section: Discussionmentioning

confidence: 83%

The role of oxytocin in modulating self–other distinction in human brain: a pharmacological fMRI study

Wang

2022

Cerebral Cortex

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The self-other distinction is crucial in human social cognition and social interaction. Studies have found that oxytocin (OT) sharpens the self-other perceptual boundary but with mixed results. Further, little is known if the effect of OT on selfresemblance facial perception exists, especially on its neural basis. Moreover, it is unclear if OT would influence the judgment in self-other discrimination when the other is a child or an adult. In the current double-blinded, placebo-controlled study, we investigated the effect of OT on self-face perception at both behavioral and neural levels. We morphed participants' faces and strangers' faces to create four stimuli conditions. After being treated by either OT or placebo (PL), participants reported whether a morphed face resembles themselves, or was morphed with their own faces, while being scanned with fMRI. Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. fMRI results showed that the OT group exhibited generally increased activities in the visual area and IFG for self-morphed faces. Such difference was more pronounced in the adult face compared to child face conditions. Multivariate fMRI analysis revealed that the OT group showed better classification between self-morphed versus othermorphed faces, indicating that OT increased self-other distinction, especially for adult faces and in the left hemisphere. Our study shows the significant effect of OT on self-referential brain processes, providing evidence for the potential OT's effect on a left hemisphere self network.

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Section: Discussionmentioning

confidence: 83%

The role of oxytocin in modulating self–other distinction in human brain: a pharmacological fMRI study

Wang

2022

Cerebral Cortex

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Section: Discussionmentioning

confidence: 99%

The role of oxytocin in modulating self-other distinction in human brain: a pharmacological fMRI study

Wang

2021

Preprint

Self Cite

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The self-other distinction is crucial in human social cognition and social interaction. Studies have found that oxytocin (OT) sharpens the self-other perceptual boundary but with mixed results. Further, little is known if the effect of OT on self-resemblance face perception exists, especially on its neural basis. Moreover, it is unclear if OT would influence the judgment in self-other discrimination when the other is a child or an adult. In the current double-blinded, placebo-controlled study, we investigated the effect of OT on self-face perception at both behavioral and neural levels. We morphed their faces with either an adult, a child, or a stranger face of either an adult or child. After being treated by either OT or placebo (PL), participants reported whether a morphed face resembles themselves while being scanned with fMRI. Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. fMRI results showed that the OT group exhibited generally increased activities in the visual area and IFG for self-morphed faces. Such difference was more pronounced in the adult face compared to child face conditions. Multivariate fMRI analysis revealed that the OT group showed better classification between self-morphed versus other-morphed faces, indicating that OT increased self-other distinction, especially for adult faces and in the left hemisphere. Our study shows the significant effect of OT on self-referential brain processes, providing evidence for the potential OT's effect on a left hemisphere self network

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“…Thus, this result may represent that people pay more attention to others (external information) and less attention to themselves, which may answer why OT can increase people's cooperative behaviors [10,61]people will consider more about the behavior of others and how they should interact with others, rather than pay more attention to their benefits. Many studies support this conclusion in some ways, such that OT can enhance the sensitivity of subjects to external cues such as aggression and pain [37,41,46,64].…”

Section: Ot Exchanged the Synchronization In Fpn And Dmnmentioning

confidence: 90%

Kuramoto model based analysis reveals oxytocin effects on brain network dynamics

Zheng¹,

Liang²,

Qu³

et al. 2021

Preprint

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The oxytocin effects on large-scale brain networks such as Default Mode Network (DMN) and Frontoparietal Network (FPN) have been largely studied using fMRI data. However, those studies are mainly based on the statistical correlation or bayesian causality inference, lacking physical and neuroscience level interpretability. Here, we propose a Kuramoto model physical-based framework to investigate oxytocin effects on the phase dynamical neural coupling in DMN and FPN. Tested on fMRI data from 59 participants administrated with either oxytocin or placebo, we demonstrate that oxytocin changes the topology of brain communities in DMN and FPN, leading to higher synchronization in the DMN and lower synchronization in the FPN, as well as a higher variance of the coupling strength within the DMN and more flexible coupling patterns across time. These results together imply that oxytocin may increase the capability to overcome the dispersion of corresponding intrinsic oscillations and yield flexibility in neural synchrony under various social contexts, providing new evidence to account for oxytocin modulated social behaviors. Our proposed Kuramoto model-based framework can be a potential tool in network neuroscience and offers physical and neural insights into phase dynamics in the brain.

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Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach

Cited by 19 publications

References 92 publications

The role of oxytocin in modulating self–other distinction in human brain: a pharmacological fMRI study

The role of oxytocin in modulating self–other distinction in human brain: a pharmacological fMRI study

The role of oxytocin in modulating self-other distinction in human brain: a pharmacological fMRI study

Kuramoto model based analysis reveals oxytocin effects on brain network dynamics

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