Intranasal Naloxone Repeat Dosing Strategies and Fentanyl Overdose
David G. Strauss,
Zhihua Li,
Anik Chaturbedi
et al.
Abstract:ImportanceQuestions have emerged as to whether standard intranasal naloxone dosing recommendations (ie, 1 dose with readministration every 2-3 minutes if needed) are adequate in the era of illicitly manufactured fentanyl and its derivatives (hereinafter, fentanyl).ObjectiveTo compare naloxone plasma concentrations between different intranasal naloxone repeat dosing strategies and to estimate their effect on fentanyl overdose.Design, Setting, and ParticipantsThis unblinded crossover randomized clinical trial wa… Show more
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